ABD e-News April 16, 2004

alcohol, beer, liquor, wine

ABD e-News March 26, 2004

Weekly Newsletter

ABD e-News April 23, 2004

Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News April 30, 2004

Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News May 7, 2004

Weekly Newsletter

ABD e-News May 14, 2004

Weekly Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News May 21, 2004

Weekly Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News May 28, 2004

Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News June 4, 2004

Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-news, June 4, 2004, EXTRA

Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News June 11, 2004

Newsletter for the State of Iowa Alcoholic Beverages Division

Physiological function of PARbZip circadian clock-controlled transcription factors.

PARbZip proteins (proline and acidic amino acid-rich basic leucine zipper) represent a subfamily of circadian transcription factors belonging to the bZip family. They are transcriptionally controlled by the circadian molecular oscillator and are suspected to accomplish output functions of the clock. In turn, PARbZip proteins control expression of genes coding for enzymes involved in metabolism, but also expression of transcription factors which control the expression of these enzymes. For example, these transcription factors control vitamin B6 metabolism, which influences neurotransmitter homeostasis in the brain, and loss of PARbZip function leads to spontaneous and sound-induced epilepsy that are frequently lethal. In liver, kidney, and small intestine, PAR bZip transcription factors regulate phase I, II, and III detoxifying enzymes in addition to the constitutive androstane receptor (CAR), one of the principal sensors of xenobiotics. Indeed, knockout mice for the three PARbZip transcription factors are deficient in xenobiotic detoxification and display high morbidity, high mortality, and accelerated aging. Finally, less than 20% of these animals reach an age of 1 year. Accumulated evidences suggest that PARbZip transcription factors play a role of relay, coupling circadian metabolism of xenobiotic and probably endobiotic substances to the core clock circuitry of local circadian oscillators.

ABD e-News June 18, 2004

Weekly Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News July 2, 2004

Weekly Newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News July 16, 2004

Newsletter for the State of Iowa Alcoholic Beverages Division