Dengue transmission risk maps of the continental United States

Dengue fever is a strictly human and non-human primate disease characterized by a high fever, thrombocytopenia, retro-orbital pain, and severe joint and muscle pain. Over 40% of the world population is at risk. Recent re-emergence of dengue outbreaks in Texas and Florida following the re-introduction of competent Aedes mosquito vectors in the United States have raised growing concerns about the potential for increased occurrences of dengue fever outbreaks throughout the southern United States. Current deficiencies in vector control, active surveillance and awareness among medical practitioners may contribute to a delay in recognizing and controlling a dengue virus outbreak. Previous studies have shown links between low-income census tracts, high population density, and dengue fever within the United States. Areas of low-income and high population density that correlate with the distribution of Aedes mosquitoes result in higher potential for outbreaks. In this retrospective ecologic study, nine maps were generated to model U.S. census tracts’ potential to sustain dengue virus transmission if the virus was introduced into the area. Variables in the model included presence of a competent vector in the county and census tract percent poverty and population density. Thirty states, 1,188 counties, and 34,705 census tracts were included in the analysis. Among counties with Aedes mosquito infestation, the census tracts were ranked high, medium, and low risk potential for sustained transmission of the virus. High risk census tracts were identified as areas having the vector, ≥20% poverty, and ≥500 persons per square mile. Census tracts with either ≥20% poverty or ≥500 persons per square mile and have the vector present are considered moderate risk. Census tracts that have the vector present but have <20% poverty and <500 persons per square mile are considered low risk. Furthermore, counties were characterized as moderate risk if 50% or more of the census tracts in that county were rated high or moderate risk, and high risk if 25% or greater were rated high risk. Extreme risk counties, which were primarily concentrated in Texas and Mississippi, were considered having 50% or greater of the census tracts ranked as high risk. Mapping of geographic areas with potential to sustain dengue virus transmission will support surveillance efforts and assist medical personnel in recognizing potential cases. ^

Molecular and evolutionary genetics of the X -linked visual pigment genes in humans and New World monkeys

Normal humans have one red and at least one green visual pigment genes. These genes are tightly linked as tandem repeats on the X chromosome and each of them has six exons. There is only one X-linked visual pigment gene in New World monkeys (NWMs) but the locus has three polymorphic alleles encoding red, yellow and green visual pigments, respectively. The spectral properties of the squirrel monkey and the marmoset (both NWMs) have been studied and partial sequences of the three alleles are available. To study the evolutionary history of these X-linked opsin genes in humans and NWMs, coding and intron sequences of the three squirrel monkey alleles and the three marmoset alleles were amplified by PCR followed by subcloning and sequencing. Introns 2 and 4 of the human red and green pigment genes were also sequenced. The results obtained are as follows: (1) The sequences of introns 2 and 4 of the human red and green opsin genes are significantly more similar between the two genes than are coding sequences, contrary to the usual situation where coding regions are better conserved in evolution than are introns. The high similarities in the two introns are probably due to recent gene conversion events during evolution of the human lineage. (2) Phylogenetic analysis of both intron and exon sequences indicates that the phylogenetic tree of the available primate opsin genes is the same as the species tree. The two human genes were derived from a gene duplication event after the divergence of the human and NWM lineages. The three alleles in each of the two NWM species diverged after the split of the two NWMs but have persisted in the population for at least 5 million years. (3) Allelic gene conversion might have occurred between the three squirrel monkey alleles. (4) A model of additive effect of hydroxyl-bearing amino acids on spectral tuning is proposed by treating some unknown variables as groups. Under the assumption that some residues have no effect, it is found that at least five amino acid residues, at positions 178 (3 nm), 180 (5 nm), 230 ($-$4 nm), 277 (9 nm) and 285 (13 nm), have linear spectral tuning effects. (5) Adaptive evolution of the opsin genes to different spectral peaks was observed at four residues that are important for spectral tuning. ^

Cross -packing among retroviruses and characterization of the feline immunodeficiency virus (FIV) packaging signal: Implications for the development of FIV-based gene transfer systems

Feline immunodeficiency virus (FIV)-based gene transfer systems are being seriously considered for human gene therapy as an alternative to vectors based on primate lentiviruses, a genetically complex group of retroviruses capable of infecting non-dividing cells. The greater phylogenetic distance between the feline and primate lentiviruses is thought to reduce chances of the generation of recombinant viruses. However, safety of FIV-based vector systems has not been tested experimentally. Since primate lentiviruses such as human and simian immunodeficiency viruses (HIV/SIV) can cross-package each other's genomes, we tested this trait with respect to FIV. Unexpectedly, both feline and primate lentiviruses were reciprocally able to both cross-package and propagate each other's RNA genomes. This was largely due to the recognition of viral packaging signals by the heterologous proteins. However, a simple retrovirus such as Mason-Pfizer monkey virus (MPMV) was unable to package FIV RNA. Interestingly, FIV could package MPMV RNA, but not propagate it for further steps of replication. These findings suggest that upon co-infection of the same host, cross-packaging may allow distinct retroviruses to generate chimeric variants with unknown pathogenic potential. ^ In order to understand the packaging determinants in FIV, we conducted a detailed mutational analysis of the region thought to contain FIV packaging signal. We show that the first 90–120 nt of the 5′ untranslated region (UTR) and the first 90 nt of gag were simultaneously required for efficient FIV RNA packaging. These results suggest that the primary FIV packaging signal is multipartite and discontinuous, composed of two core elements separated by 150 nt of the 5 ′UTR. ^ The above studies are being used towards the development of safer FIV-based self-inactivating (SIN) vectors. These vectors are being designed to eliminate the ability of FIV transfer vector RNAs to be mobilized by primate lentiviral proteins that may be present in the target cells. Preliminary test of the first generation of these vectors has revealed that they are incapable of being propagated by feline proteins. The inability of FIV transfer vectors to express packageable vector RNA after integration should greatly increase the safety of FIV vectors for human gene therapy. ^

Sófocles : Áyax, una mirada desde la Justicia

En Ayax de Sófocles, se rompe la cadena inexorable de odios heredados, porque alguien, Teucro, acepta la mano tendida del adversario, Odiseo. Blundell remarca este lento pero efectivo caminar hacia la conciliación. Nuestro trabajo se propone una mirada "desde la justicia" humana y divina. Efectúa un rastreo sobre el juicio de Ayax a través de visiones de la épica tardía, la lírica y la tragedia y descubre en esta obra la confluencia de juicios injustos del pasado y el comienzo de futuros juicios también injustos. El interés por la instancia judicial nos lleva al análisis de la constitución del tribunal, su modo de proceder y las consecuencias de su accionar. También nos detenemos en el enfoque religioso elegido por Sófocles. Por último se evalúa la tragedia a la luz de los estadios de evolución del sentimiento de venganza

El desarrollo como estrategia adaptativa : Características exclusivas de la infancia humana

En este trabajo se presenta una hipótesis evolucionista acerca del desarrollo. Se compara la infancia humana con la de los primates no humanos y se describen sus rasgos exclusivos vinculados con la extensión y transformación del mundo emocional, la interacción adulto-bebé y la formación de procesos psicológicos complejos. Se argumenta a favor del papel constitutivo de las artes temporales en cada uno de los rasgos descriptos

Forma y contexto : La tensión arendtiana en torno al problema del juicio

Este trabajo pretende ser una aproximación al pensamiento de H. Arendt desde la perspectiva del interés de la autora por el problema del juicio. Para ello nos concentraremos en la peculiar interpretación que Arendt realizó de la Crítica de la facultad de juzgar de Kant, texto del cual la filósofa se apropió para reflexionar sobre la política y no sobre la estética. A partir de dicho análisis mostraremos que tal interpretación presenta varias dificultades, que encuentran uno de sus principales puntos de origen en el inusual tránsito arendtiano de Aristóteles hacia Kant para el desarrollo de sus consideraciones políticas. En ese sentido, señalaremos las posibles razones del mencionado tránsito y trataremos de proponer una vía de conciliación a través de una contextualización apropiada del pensamiento de Aristóteles que nos permita reconectarlo con los intereses de la filosofía política de Arendt

El desarrollo como estrategia adaptativa : Características exclusivas de la infancia humana

En este trabajo se presenta una hipótesis evolucionista acerca del desarrollo. Se compara la infancia humana con la de los primates no humanos y se describen sus rasgos exclusivos vinculados con la extensión y transformación del mundo emocional, la interacción adulto-bebé y la formación de procesos psicológicos complejos. Se argumenta a favor del papel constitutivo de las artes temporales en cada uno de los rasgos descriptos

Forma y contexto : La tensión arendtiana en torno al problema del juicio

Este trabajo pretende ser una aproximación al pensamiento de H. Arendt desde la perspectiva del interés de la autora por el problema del juicio. Para ello nos concentraremos en la peculiar interpretación que Arendt realizó de la Crítica de la facultad de juzgar de Kant, texto del cual la filósofa se apropió para reflexionar sobre la política y no sobre la estética. A partir de dicho análisis mostraremos que tal interpretación presenta varias dificultades, que encuentran uno de sus principales puntos de origen en el inusual tránsito arendtiano de Aristóteles hacia Kant para el desarrollo de sus consideraciones políticas. En ese sentido, señalaremos las posibles razones del mencionado tránsito y trataremos de proponer una vía de conciliación a través de una contextualización apropiada del pensamiento de Aristóteles que nos permita reconectarlo con los intereses de la filosofía política de Arendt

Sófocles : Áyax, una mirada desde la Justicia

En Ayax de Sófocles, se rompe la cadena inexorable de odios heredados, porque alguien, Teucro, acepta la mano tendida del adversario, Odiseo. Blundell remarca este lento pero efectivo caminar hacia la conciliación. Nuestro trabajo se propone una mirada "desde la justicia" humana y divina. Efectúa un rastreo sobre el juicio de Ayax a través de visiones de la épica tardía, la lírica y la tragedia y descubre en esta obra la confluencia de juicios injustos del pasado y el comienzo de futuros juicios también injustos. El interés por la instancia judicial nos lleva al análisis de la constitución del tribunal, su modo de proceder y las consecuencias de su accionar. También nos detenemos en el enfoque religioso elegido por Sófocles. Por último se evalúa la tragedia a la luz de los estadios de evolución del sentimiento de venganza

El desarrollo como estrategia adaptativa : Características exclusivas de la infancia humana

En este trabajo se presenta una hipótesis evolucionista acerca del desarrollo. Se compara la infancia humana con la de los primates no humanos y se describen sus rasgos exclusivos vinculados con la extensión y transformación del mundo emocional, la interacción adulto-bebé y la formación de procesos psicológicos complejos. Se argumenta a favor del papel constitutivo de las artes temporales en cada uno de los rasgos descriptos

Sófocles : Áyax, una mirada desde la Justicia

En Ayax de Sófocles, se rompe la cadena inexorable de odios heredados, porque alguien, Teucro, acepta la mano tendida del adversario, Odiseo. Blundell remarca este lento pero efectivo caminar hacia la conciliación. Nuestro trabajo se propone una mirada "desde la justicia" humana y divina. Efectúa un rastreo sobre el juicio de Ayax a través de visiones de la épica tardía, la lírica y la tragedia y descubre en esta obra la confluencia de juicios injustos del pasado y el comienzo de futuros juicios también injustos. El interés por la instancia judicial nos lleva al análisis de la constitución del tribunal, su modo de proceder y las consecuencias de su accionar. También nos detenemos en el enfoque religioso elegido por Sófocles. Por último se evalúa la tragedia a la luz de los estadios de evolución del sentimiento de venganza

Forma y contexto : La tensión arendtiana en torno al problema del juicio

Este trabajo pretende ser una aproximación al pensamiento de H. Arendt desde la perspectiva del interés de la autora por el problema del juicio. Para ello nos concentraremos en la peculiar interpretación que Arendt realizó de la Crítica de la facultad de juzgar de Kant, texto del cual la filósofa se apropió para reflexionar sobre la política y no sobre la estética. A partir de dicho análisis mostraremos que tal interpretación presenta varias dificultades, que encuentran uno de sus principales puntos de origen en el inusual tránsito arendtiano de Aristóteles hacia Kant para el desarrollo de sus consideraciones políticas. En ese sentido, señalaremos las posibles razones del mencionado tránsito y trataremos de proponer una vía de conciliación a través de una contextualización apropiada del pensamiento de Aristóteles que nos permita reconectarlo con los intereses de la filosofía política de Arendt

Myanmar and Japan: How Close Friends Become Estranged

Independent Myanmar and Japan had long held the strongest ties among Asian countries, and they were often known as having "special relations" or a "historically friendly relationship." Such relations were guaranteed by the sentiments and experiences of the leaders of both countries. Among others, Ne Win, former strongman throughout the socialist period (1962-1988), was educated and trained by the Japanese army officers of the Minami Kikan, leading to the birth of the Burma Independence Army (BIA). Huge official development assistance provided by the Japanese government also cemented this special relationship. However, the birth of the present military government (SLORC/SPDC) in 1988 drastically changed this favorable relationship between the two countries. When the military seized power in a coup, Japan was believed to be the only country that possessed sufficient meaningful influence on Myanmar to encourage a move toward national reconciliation between the junta and the opposition party led by Aung San Suu Kyi. In reality, Japan failed to exert such an influence due to its sour relations with the military government and reduced influence in the new international and regional political landscape. What is worse, Japan seems to be losing its say on Myanmar issues in the international political arena, as it has been wavering in limbo between the sanctionist forces, such as the United States and the European Union, and engagement forces, such as China and ASEAN.

The urban middle class in the instability of new democracies

The recent revolts of the middle class in the national capitals of the Philippines and Thailand have raised a new question about democratic consolidation. Why would the urban middle class, which is expected to stabilize democracy, expel the democratically elected leaders through extra-constitutional action? This article seeks to explain such middle class deviation from democratic institutions through an examination of urban primacy and the change in the winning coalition. The authoritarian regime previously in power tended to give considerable favor to the primate city to prevent it revolting against the ruler, because it could have become a menace to his power. But after democratization the new administration shifts policy orientation from an urban to rural bias because it needs to garner support from rural voters to win elections. Such a shift dissatisfies the middle class in the primate city. In this article I take up the Philippines as a case study to examine this theory.

Parameterization of applied general equilibrium models with flexible trade specifications based on the Armington, Krugman, and Melitz models

This paper explains how the Armington-Krugman-Melitz supermodel developed by Dixon and Rimmer can be parameterized, and demonstrates that only two kinds of additional information are required in order to extend a standard trade model to include Melitz-type monopolistic competition and heterogeneous firms. Further, it is shown how specifying too much additional information leads to violations of the model constraints, necessitating adjustment and reconciliation of the data. Once a Melitz-type model is parameterized, a Krugman-type model can also be parameterized using the calibrated values in the Melitz-type model without any additional data. Sample code for the General Algebraic Modeling System (GAMS) has also been prepared to promote the innovative supermodel in the AGE community.