Notebook of John Allen, 1772

Paper-covered notebook containing handwritten poems and verse by Harvard graduate John Allen. Some of the poems refer to Allen’s illnesses in October 1772. The notebook also contains a short list titled “The Gentleman that I wrote diplomas for," with a list of sixteen individuals who received degrees from Harvard. The inside cover includes the inscription: “John Allen – November 4, 1772. Poetic Composition.” “Dr. T. C. Gilman” is stamped on cover.

The white gene and locomotor recovery from anoxia in Drosophila melanogaster

Locomotor recovery from anoxia is complicated and little is known about the molecular and cellular mechanisms regulating anoxic recovery in Drosophila. For this thesis I established a protocol for large-scale analysis of locomotor activity in adult flies with exposure to a transient anoxia. Using this protocol I observed that wild-type Canton-S flies recovered faster and more consistently from anoxia than the white-eyed mutant w1118, which carries a null allele of w1118 in an isogenic genetic background. Both Canton-S and w1118 are commonly used controls in the Drosophila community. Genetic analysis including serial backcrossing, RNAi knockdown, w+ duplication to Y chromosome as well as gene mutation revealed a strong association between the white gene and the timing of locomotor recovery. I also found that the locomotor recovery phenotype is independent of white-associated eye pigmentation, that heterozygous w+ allele was haplo-insufficient to induce fast and consistent locomotor recovery from anoxia in female flies, and that mini-white is insufficient to promote fast and consistent locomotor recovery. Moreover, locomotor recovery was delayed in flies with RNAi knockdown of white in subsets of serotonin neurons in the central nervous system. I further demonstrated that mutations of phosphodiesterase genes (PDE) displayed wild-type-like fast and consistent locomotor recovery, and that locomotor recovery was light-sensitive in the night in w1118. The delayed locomotor recovery and the light sensitivity were eliminated in PDE mutants that were dual-specific or cyclic guanosine monophosphate (cGMP)-specific. Up-regulation of cGMP using multiple approaches including PDE mutation, sildenafil feeding or specific expression of an atypical soluble guanylyl cyclase (Gyc88E) was sufficient to suppress w-RNAi induced delay of locomotor recovery. Taken together, these data strongly support the hypothesis that White transports cGMP and promotes fast and consistent locomotor recovery from anoxia.

Stage-Specific Plasticity in Ovary Size Is Regulated by Insulin/Insulin-Like Growth Factor and Ecdysone Signaling in Drosophila

Animals from flies to humans adjust their development in response to environmental conditions through a series of developmental checkpoints, which alter the sensitivity of organs to environmental perturbation. Despite their importance, we know little about the molecular mechanisms through which this change in sensitivity occurs. Here we identify two phases of sensitivity to larval nutrition that contribute to plasticity in ovariole number, an important determinant of fecundity, in Drosophila melanogaster. These two phases of sensitivity are separated by the developmental checkpoint called "critical weight"; poor nutrition has greater effects on ovariole number in larvae before critical weight than after. We find that this switch in sensitivity results from distinct developmental processes. In precritical weight larvae, poor nutrition delays the onset of terminal filament cell differentiation, the starting point for ovariole development, and strongly suppresses the rate of terminal filament addition and the rate of increase in ovary volume. Conversely, in postcritical weight larvae, poor nutrition affects only the rate of increase in ovary volume. Our results further indicate that two hormonal pathways, the insulin/insulin-like growth factor and the ecdysone-signaling pathways, modulate the timing and rates of all three developmental processes. The change in sensitivity in the ovary results from changes in the relative contribution of each pathway to the rates of terminal filament addition and increase in ovary volume before and after critical weight. Our work deepens our understanding of how hormones act to modify the sensitivity of organs to environmental conditions, thereby affecting their plasticity.

The life of the fly : with which are interspersed some chapters of autobiography /

"The present volume contains all the essays on flies, or Diptera, from the Souvenirs entomologiques, to which I have added, in order to make the dimensions uniform with those of the other volumes of the series, the purely autobiographical essays comprised in the Souvenirs."--Translator's note.

The book of the fly; a nature study of the house-fly and its kin, the fly plague and a cure.

Mode of access: Internet.

Actions and reactions /

An habitation enforced -- The recall -- Garm, a hostage -- The power of the dog -- The mother hive -- The bees and the flies --With the night mail -- The four angels -- A deal in cotton -- The new knighthood -- The puzzler -- Little foxes -- Gallio's song -- The house surgeon -- The rabbi's song.

Isoachlya toruloides; Saprolegniaceae

Isoachlya toruloides Kauffman & Coker in Kauffman

Eradication of cattle grubs. Hearings before the Subcommittee No. 4 of the Committee on Agriculture, House of Representatives, Eightieth Congresses, second session, on S. 1249 and H. R. 1043. Apr. 6 and 28, 1948.

George W. Gillie, chairman of subcommittee.

Fly patterns and their origins,

"3d printing April, 1946."

Actions and reactions,

An habitation enforced.--The recall.--Garm--a hostage.--The power of the dog.--The mother hive.--The bees and the flies.--With the night mail.--The four angels.--A deal in cotton.--The new knighthood.--The puzzler.--The puzzler.--Little foxes.--Gallio's song.--The house surgeon.--The rabbi's song.

Fly fishing,

Short bibliography included in the preface.

Über Tipuliden-Larven mit besonderer Berücksichtigung der Respirationsorgane.

Mode of access: Internet.

The reproductive organs and the newly hatched larva of the warble-fly (Hypoderma)

Mode of access: Internet.

Fighting the fly peril; a popular and practical handbook,

Mode of access: Internet.