The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progression to Metastatic Prostate Cancer and Refractoriness to Hormonal Castration

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF1A +1772 C>T (rs11549465) polymorphism was genotyped, using DNA isolated from peripheral blood, in 1490 male subjects (754 with prostate cancer and 736 controls cancer-free) through Real-Time PCR. A nested group of cancer patients who were eligible for androgen deprivation therapy was followed up. Univariate and multivariate models were used to analyse the response to hormonal treatment and the risk for developing distant metastasis. Age-adjusted odds ratios were calculated to evaluate prostate cancer risk. Our results showed that patients under ADT carrying the HIF1A +1772 T-allele have increased risk for developing distant metastasis (OR, 2.0; 95%CI, 1.1-3.9) and an independent 6-fold increased risk for resistance to ADT after multivariate analysis (OR, 6.0; 95%CI, 2.2-16.8). This polymorphism was not associated with increased risk for being diagnosed with prostate cancer (OR, 0.9; 95%CI, 0.7-1.2). The HIF1A +1772 genetic polymorphism predicts a more aggressive prostate cancer behaviour, supporting the involvement of HIF1a in prostate cancer biological progression and ADT resistance. Molecular profiles using hypoxia markers may help predict clinically relevant prostate cancer and response to ADT.

Heráldica, representação do poder e memória da nação. O armorial autárquico de Inácio de Vilhena Barbosa

Tendo como ponto de partida o armorial autárquico publicado por Inácio de Vilhena Barbosa em 1860, o presente trabalho incide sobre a relação entre a heráldica municipal e a representação do poder. O principal objectivo consiste em verificar de que modo o conjunto das armas autárquicas foi usado, desde o Antigo Regime até à monarquia constitucional, como parte integrante dos instrumentos de consagração política e de construção da memória. Foca-se em particular o papel que esse armorial desempenhou no processo oitocentista de edificação do Estado liberal, na afirmação da identidade nacional e na atestação abstracta de uma soberania da nação. A edição do armorial autárquico português na segunda metade do século XIX, longe de constituir um caso isolado, encontrou paralelo nos demais países europeus, onde tal género de publicação assumiu características e funções similares. Esta funcionalidade esteve na base da difusão das séries de armas municipais e da sua repetição em lugares associados à simbólica do poder ou à instrução cívica dos cidadãos.

An automated framework for the management of P2P traffic in ISP infrastructures

Peer-to-Peer (P2P) is nowadays a widely used paradigm underpinning the deployment of several Internet services and applications. However, the management of P2P traffic aggregates is not an easy task for Internet Service Providers (ISPs). In this perspective, and considering an expectable proliferation in the use of such ap- plications, future networks require the development of smart mechanisms fostering an easier coexistence between P2P applications and ISP infrastructures. This paper aims to contribute for such research efforts presenting a framework incorporating useful mechanisms to be activated by network administrators, being also able to operate as an automated management tool dealing with P2P traffic aggregates.

Automated network resilience optimization using computational intelligence methods

This paper presents an automated optimization framework able to provide network administrators with resilient routing configurations for link-state protocols, such as OSPF or IS-IS. In order to deal with the formulated NP-hard optimization problems, the devised framework is underpinned by the use of computational in- telligence optimization engines, such as Multi-objective Evolutionary Algorithms (MOEAs). With the objective of demonstrating the framework capabilities, two il- lustrative Traffic Engineering methods are described, allowing to attain routing con- figurations robust to changes in the traffic demands and maintaining the network stable even in the presence of link failure events. The presented illustrative results clearly corroborate the usefulness of the proposed automated framework along with the devised optimization methods.

A geographic opportunistic forwarding strategy for vehicular named data networking

Studies in Computational Intelligence, 616

Flora oder Botanische Zeitung :welche Recensionen, Abhandlungen, Aufsätze, Neuigkeiten und Nachrichten, die Botanik betreffend, enthält /herausgegeben von der Königl. Botanischen Gesellschaft in Regensburg.

v.43 (1860)

Icones plantarum Indiae Orientalis :or figures of Indian plants /by Robert Wight.

v.5 (1852)

Flora van Nederlandsch Indië /door F. A. W. Miquel.

suppl. 1

L'Illustration horticole : journal spécial des serres et des jardins, ou choix raisonné des plantes les plus intérressantes sous le rapport ornemental, comprenant leur histoire complete, leur description comparée, leur figure et leur culture /

v.7 (1860)

Flora of the Rocky Mountains and adjacent plains, Colorado, Utah, Wyoming, Idaho, Montana, Saskatchewan, Alberta, and neighboring parts of Nebraska, South Dakota, and British Columbia /by P. A. Rydberg...

1917

Fragmenta phytographiæ Australiæ /contulit Ferdinandus Mueller.

v.2 1860-61

Tentamen florae Abyssinicae :seu, Enumeratio plantarum hucusque in plerisque Abyssiniae provinciis detectarum et praecipue a beatis doctoribus Richard Quartin Dillon et Antonio Petit (annis 1838-1843) lectarum /auctore Achille Richard.

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