914 resultados para integrity in closed-loop


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Pós-graduação em Enfermagem (mestrado profissional) - FMB

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Pós-graduação em Engenharia Mecânica - FEG

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The Livistona rotundifolia species is native to Oceania, and has a high potential for landscaping use and as a pot plant. This work aimed to study the effects of the maturation stage, pulp removal and storage on the germination of L. rotundifolia seeds. The experimental design was entirely randomized in a factorial arrangement 5x2x2 (five storage periods: 15, 30, 45, 60 and 75 days; two maturation stages: green and ripe; and the presence or absence of the pulp - exocarp and mesocarp) with four replications of 25 seeds each. After sorting out the fruits by the maturity stage and removing the pulp out of half of the fruits from each plot, the seeds were placed in closed bottles, which were sealed and stored in a cold chamber at 10 degrees C. The seeds were removed from the cold chamber and left to germinate in plastic boxes (gerbox type) with sphagnum. The boxes were kept at 25-35 degrees C and photoperiod of 12 hours. The germination rate was determined when seed germination was steady. The highest germination rate was found when green fruits had their pulp removed. The germination rate gradually decreased with the increase of the storage period regardless the maturation stage and the presence or absence of the pulp.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Snakes from Bothrops genus are responsible for more than 90% of the ophidian accidents in Brazil. One of the main complications from this kind of accident is muscular necrosis, which is related to the action of phospholipases A2 and metalloproteases, two groups of enzymes found in the venom of these animals. Although this complication cannot be solved by serum therapy administration, a great number of studies have been performed with the attempt to know the pharmacological sites of these toxins aiming, in the future, the development of complementary treatments to serum therapy. This work proposes structural studies of bothropic phospholipases A2 (PLA2s) in the presence of ions relevant to their activity, using the X-ray crystallography technique. Recently, it was demonstrated ions, as manganese, calcium and others, interfere in the biological activity of the PLA2s. Particularly, Lys49-PLA2s in the presence of manganese ions have miotoxicity reduced. Asp49-PLA2s show catalytic activity dependent of calcium, although structural studies with a miotoxic Asp49-PLA2, BthTX-II, suggest a possible catalytic mechanism independent of calcium. Therefore, co-crystallization of BthTX-II in the presence of calcium ions and of PrTX-I in the presence of manganese ions were performed. Comparative structural studies among obtained results and others already published in the literature were performed aiming a better understanding of the structure-function relationship of these toxins. The BthTX-II with the presence of calcium do not show this ion in the loop of coordination of calcium, presence necessary to develop the catalyses. After comparison of this model with the native one, only one distortion was found, but no apparent relationship with the residues responsible for its activity. In the PrTX-I structure, regions candidates of manganese ions were also found... (Complete abstract click electronic access below)

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Our twenty-first century society and the rhythm of life and work we have to face in our daily routine compel us to spend most of our lifetime in closed environments, in our houses, educational institutions, hospitals, airports, amongst as many others. The study of the air quality in internal environments (IAQ) is very important for monitoring people’s health effects and their environmental comfort in these locations. One essential parameter to analyze this measure is to evaluate the concentration of dispersed particulates in the air, specially focusing on those thinner particles (below the diameter of 2,5 μm), they can pose serious risks for human being because they can remain in the lungs, penetrate through the pores of our skin, amongst other harmful effects on human’s health. In this work the air quality inside the public library Profª Josina Vasques Ferrari and at Unesp public state library was evaluated, both located in Itapeva, as well as a third one, inside the Communitarian Library of the Federal University in Carlos (UFSCar) from march to may in 2012. In those environments it was analyzed if the concentration of particulates pose any real treat to the users. The equipment used for particle sampling in real time was DataRam 4 (Model DR 4000). The results given for those concentrations of particulates in both internal and external environments revealed figures within the safe standard established by the WHO (World Health Organization), from 25 to μg/m³, the only exception occurred on the fifth floor of the UFSCar library, where the average for concentration stayed at 25,30 of μg/m³

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Pós-graduação em Genética e Melhoramento Animal - FCAV

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Pós-graduação em Engenharia Civil - FEIS

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This article provides reflections and discussions about the importance of human interactions and methodological interrelations to substantiate the integrity in the transdisciplinary process in teams that operate in health area. Should be taken as reference the Complexity Theory of Edgar Morin, the logic transdisciplinary of Basarab Nicolescu and the formation groups principles based on the Socionomic Theory of Jacob Levy Moreno. It was concluded that the complexity of the methodologies in the field of workplace health, are influenced by factors that intersect between the scientific interaction and human interrelationships, which allow the transdisciplinary construction. However, the constructions requires the development of professionals in their areas and in their relationship with others as a way of supporting the perspective of transdisciplinarity, ie, interaction, in which different individuals are interrelated with the methodologies and providing articulations and coconstructions from which actualize the transformations.

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Phase transitions involving spontaneous time-reversal symmetry breaking are studied on the honeycomb lattice at finite hole doping with next-nearest-neighbor repulsion. We derive an exact expression for the mean-field equation of state in closed form, valid at temperatures much less than the Fermi energy. Contrary to standard expectations, we find that thermally induced intraband particle-hole excitations can create and stabilize a uniform metallic phase with broken time-reversal symmetry as the temperature is raised in a region where the ground state is a trivial metal.

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The purpose of this study was to evaluate the impact of different disinfection solutions on flexural resistance of chemically-activated acrylic resin. Test pieces were made of clear acrylic resin using a rectangular mold and employing two techniques: wet polymerization under pressure (n = 20) and dry polymerization under pressure (n = 20). Test pieces were subdivided into four equal groups: distilled water (control), sodium bicarbonate, 1% sodium hypochlorite and effervescent ats. The 30-day cycling technique consisted of immersing the test pieces in 100 ml of solution for 10 min three times a day and placing them in closed containers containing artificial saliva at 37°C. Subsequently, the flexural resistance of samples was tested. Data were analyzed using two-way analysis of variance (ANOVA) with forces serving as the dependent variables and the polymerization technique and cleaning agents as independent variables. Post hoc multiple comparisons were performed using Tukey’s test. There was no statistically significant difference in the flexural strength between the two polymerization techniques. The greatest flexural strength was observed for the effervescent tablets group followed by the control and 1% sodium hypochlorite groups which were statistically similar. Thus, the sodium bicarbonate solution caused the lowest flexural resistance of the test pieces.

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Pós-graduação em Psicologia do Desenvolvimento e Aprendizagem - FC

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)