Associations Between Personal Cancer History and Lung Cancer Risk

The study aim was to investigate the relationship between factors related to personal cancer history and lung cancer risk as well as assess their predictive utility. Characteristics of interest included the number, anatomical site(s), and age of onset of previous cancer(s). Data from the Prostate, Lung, Colorectal and Ovarian Screening (PLCO) Cancer Screening Trial (N = 154,901) and National Lung Screening Trial (N = 53,452) were analysed. Logistic regression models were used to assess the relationships between each variable of interest and 6-year lung cancer risk. Predictive utility was assessed through changes in area-under-the-curve (AUC) after substitution into the PLCOall2014 lung cancer risk prediction model. Previous lung, uterine and oral cancers were strongly and significantly associated with elevated 6-year lung cancer risk after controlling for confounders. None of these refined measures of personal cancer history offered more predictive utility than the simple (yes/no) measure already included in the PLCOall2014 model.

The Influence of Sex on the Relationship Between Arterial Mechanical Properties and Cardiovagal Baroreflex Sensitivity

Cardiovagal baroreflex sensitivity (cvBRS) demonstrates a strong relationship with arterial mechanical properties. Both cvBRS and arterial mechanics differ by sex such that males demonstrate greater cvBRS, yet lower large artery elasticity than females. Whether the relationship between cvBRS and arterial mechanics is similar in males and females remains unexamined. As a result, it is unclear whether arterial mechanics contribute to sex differences in cvBRS. This study investigated the cross-sectional relationship between cvBRS and arterial mechanical properties of the common carotid, carotid sinus and aortic arch (AA) in 36 (18 females) young, healthy normotensives. The cvBRS-arterial mechanics relationship did not reach statistical significance and did not differ by sex. Both cvBRS and AA distensibility were greater in females than males. Sex differences in cvBRS were eliminated after controlling for AA distensibility. These findings suggest that in this sample, AA elasticity may contribute to the greater cvBRS in females than males.

Indenture between Alfred Sanderson Woodruff and the United States Trust Company of New York

Indenture between Alfred Sanderson Woodruff and the United States Trust Company of New York. The proceeds would be paid to his estate for his successors. January 12, 1894.

Indenture between Hamilton Killaly Woodruff and the United States Trust Company of New York

Indenture between Hamilton Killaly Woodruff and the United States Trust Company of New York. The proceeds would be paid to his successors. (This is a handwritten copy)

Indenture between Hamilton Killaly Woodruff and the United States Trust Company of New York (3rd Trust Deed)

Indenture between Hamilton Killaly Woodruff and the United States Trust Company of New York. This is listed as the 3rd trust deed. The proceeds would be paid to successors (2 copies). Most of the first page of copy no. 2 is torn away which does affect the text. These 2 documents are in an envelope marked "vouchers", June 20, 1899.

(A) Photoregulation of DNA Functions by Cyclic Azobenzene-tethered Oligonucleotides (B) Site-specific Fluorescent Labeling of DNA using Inverse Electron Demand Diels-Alder Reaction between trans-Cyclooctene Derivatives and BODIPY-Tetrazine Adducts

(A) Most azobenzene-based photoswitches require UV light for photoisomerization, which limit their applications in biological systems due to possible photodamage. Cyclic azobenzene derivatives, on the other hand, can undergo cis-trans isomerization when exposed to visible light. A shortened synthetic scheme was developed for the preparation of a building block containing cyclic azobenzene and D-threoninol (cAB-Thr). trans-Cyclic azobenzene was found to thermally isomerize back to the cis-form in a temperature-dependent manner. cAB-Thr was transformed into the corresponding phosphoramidite and subsequently incorporated into oligonucleotides by solid phase synthesis. Melting temperature measurement suggested that incorporation of cis-cAB into oligonucleotides destabilizes DNA duplexes, these findings corroborate with circular dichroism measurement. Finally, Fluorescent Energy Resonance Transfer experiments indicated that trans-cAB can be accommodated in DNA duplexes. (B) Inverse Electron Demand Diels-Alder reactions (IEDDA) between trans-olefins and tetrazines provide a powerful alternative to existing ligation chemistries due to its fast reaction rate, bioorthogonality and mutual orthogonality with other click reactions. In this project, an attempt was pursued to synthesize trans-cyclooctene building blocks for oligonucleotide labeling by reacting with BODIPY-tetrazine. Rel-(1R-4E-pR)-cyclooct-4-enol and rel-(1R,8S,9S,4E)-Bicyclo[6.1.0]non-4-ene-9-ylmethanol were synthesized and then transformed into the corresponding propargyl ether. Subsequent Sonogashira reactions between these propargylated compounds with DMT-protected 5-iododeoxyuridine failed to give the desired products. Finally a methodology was pursued for the synthesis of BODIPY-tetrazine conjugates that will be used in future IEDDA reactions with trans-cyclooctene modified oligonucleotides.

Indenture between The Corporation of the Township of Grantham of the County of Lincoln and Samuel DeVeaux Woodruff

Indenture of bargain and sale between The Corporation of the Township of Grantham of the County of Lincoln and Samuel DeVeaux Woodruff of St. Catharines regarding part of the road allowance between Lots no. 12 and 13 of the 8th Concession of the Township of Grantham. This was registered January 8, 1874 in the County of Lincoln - instrument no. 1650, October 24, 1873.

Indenture between Jacob Thomas Nottle and George Steel

Indenture of assignment of mortgage between Jacob Thomas Nottle, land agent of Hamilton and George Steel of the Village of Romoka in the County of Middlesex regarding a parcel of land in the village of Romoka composed of Lot no. 17 in Block U. Robert Telfer granted to Ira Spalding these lands and premises subject to payment of principal money and interest (2 copies), June 18, 1874.

Indenture between Samuel DeVeaux Woodruff and The Corporation of the City of St. Catharines

Indenture of agreement between Samuel DeVeaux Woodruff of St. Catharines and the Corporation of the City of St. Catharines regarding part of Lot no. 20 in the 5th Concession in the Township of Grantham - instrument no. 1013, December 8, 1877.

Indenture of Agreement for Sale of Land between S.D. Woodruff and Elizabeth Cudney

Indenture of agreement for Sale of Land between S.D. Woodruff of St. Catharines and Elizabeth Cudney of Willoughby regarding a footpath and Lots 9 and 10 in Willoughby, Feb. 6, 1893.

Letter to S.D. Woodruff in order to give Mr. Woodruff and idea of how fast the interest payments are made to the company

Letter (incomplete) to S.D. Woodruff in order to give Mr. Woodruff an idea of how fast the interest payments are made to the company. The letter is slightly water damaged. The text is affected, but legible. The signature is missing. Feb. 8, 1883.

Indenture of memorandum of an agreement between S.D. Woodruff and James L. Burton and M. Burton

Indenture of memorandum of an agreement between S.D. Woodruff of St. Catharines and James L. Burton and M. Burton, both of Barrie, trading under the name of Burton and Bro. that Burton and Bro. would buy all the pine timber located in berths 192 and 198. Burton and Bro. agrees to have all timber cut. The agreement is signed by S.D. Woodruff and Burton and Bro. This document is badly burned along the left hand side. This does not affect the text, July 11, 1877.

Agreement between S.D. Woodruff and Nathaniel Dyment of Barrie

Agreement between S.D. Woodruff and Nathaniel Dyment of Barrie. S.D. Woodruff is the owner of license no. 198 of season 1877/78 for berth no. 198. S.D. Woodruff has agreed to sell this license, Nov. 23, 1877.

Clipping from a Town Council meeting at which estimates of the costs of Railway Line no. 1 and Line no. 2 were submitted by the office of Port Dalhousie and Thorold Railway

Clipping from a Town Council meeting at which estimates of the costs of Railway Line no. 1 and Line no. 2 were submitted by the office of Port Dalhousie and Thorold Railway. The estimate was submitted by S.D. Woodruff and George Rykert, president. There is also a disclaimer in which Calvin Phelps claims to have resigned as director of the Port Dalhousie and Thorold Railway when he discovered that the company had no intention to adhere to the original plan for building and running the road, Aug. 1854.

List which includes costs, plans and receipts for amounts received between S.D. Woodruff and Boyd and Schurr

List (8 pages, handwritten) which includes costs, plans and receipts for amounts received between S.D. Woodruff and Boyd and Schurr, Dec. 3, 1875.