The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding.

Specific DNA binding to the core consensus site GAGAGAG has been shown with an 82-residue peptide (residues 310-391) taken from the Drosophila transcription factor GAGA. Using a series of deletion mutants, it was demonstrated that the minimal domain required for specific binding (residues 310-372) includes a single zinc finger of the Cys2-His2 family and a stretch of basic amino acids located on the N-terminal end of the zinc finger. In gel retardation assays, the specific binding seen with either the peptide or the whole protein is zinc dependent and corresponds to a dissociation constant of approximately 5 x 10(-9) M for the purified peptide. It has previously been thought that a single zinc finger of the Cys2-His2 family is incapable of specific, high-affinity binding to DNA. The combination of an N-terminal basic region with a single Cys2-His2 zinc finger in the GAGA protein can thus be viewed as a novel DNA binding domain. This raises the possibility that other proteins carrying only one Cys2-His2 finger are also capable of high-affinity specific binding to DNA.

The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins.

We have identified and further characterized a Caenorhabditis elegans gene, CEZF, that encodes a protein with substantial homology to the zinc finger and leucine zipper motifs of the human gene products AF10, MLLT6, and BR140. The first part of the zinc finger region of CEZF has strong similarity to the corresponding regions of AF10 (66%) and MLLT6 (64%) at the cDNA level. As this region is structurally different from previously described zinc finger motifs, sequence homology searches were done. Twenty-five other proteins with a similar motif were identified. Because the functional domain of this motif is potentially disrupted in leukemia-associated chromosomal translocations, we propose the name of leukemia-associated protein (LAP) finger. On the basis of these comparisons, the LAP domain consensus sequence is Cys1-Xaa1-2-Cys2-Xaa9-21-Cys3-Xaa2-4 -Cys4-Xaa4-5-His5-Xaa2-Cys6-Xaa12-46 - Cys7-Xaa2-Cys8, where subscripted numbers represent the number of amino acid residues. We review the evidence that this motif binds zinc, is the important DNA-binding domain in this group of regulatory proteins, and may be involved in leukemogenesis.

Advanced interpretation of subsidence in Murcia (SE Spain) using A-DInSAR data – modelling and validation

Subsidence is a natural hazard that affects wide areas in the world causing important economic costs annually. This phenomenon has occurred in the metropolitan area of Murcia City (SE Spain) as a result of groundwater overexploitation. In this work aquifer system subsidence is investigated using an advanced differential SAR interferometry remote sensing technique (A-DInSAR) called Stable Point Network (SPN). The SPN derived displacement results, mainly the velocity displacement maps and the time series of the displacement, reveal that in the period 2004–2008 the rate of subsidence in Murcia metropolitan area doubled with respect to the previous period from 1995 to 2005. The acceleration of the deformation phenomenon is explained by the drought period started in 2006. The comparison of the temporal evolution of the displacements measured with the extensometers and the SPN technique shows an average absolute error of 3.9±3.8 mm. Finally, results from a finite element model developed to simulate the recorded time history subsidence from known water table height changes compares well with the SPN displacement time series estimations. This result demonstrates the potential of A-DInSAR techniques to validate subsidence prediction models as an alternative to using instrumental ground based techniques for validation.

Forensic analysis of buildings affected by mining subsidence based on Differential Interferometry (Part III)

This work presents a forensic analysis of buildings affected by mining subsidence, which is based on deformation data obtained by Differential Interferometry (DInSAR). The proposed test site is La Union village (Murcia, SE Spain) where subsidence was triggered in an industrial area due to the collapse of abandoned underground mining labours occurred in 1998. In the first part of this work the study area was introduced, describing the spatial and temporal evolution of ground subsidence, through the elaboration of a cracks map on the buildings located within the affected area. In the second part, the evolution of the most significant cracks found in the most damaged buildings was monitored using biaxial extensometric units and inclinometers. This article describes the work performed in the third part, where DInSAR processing of satellite radar data, available between 1998 and 2008, has permitted to determine the spatial and temporal evolution of the deformation of all the buildings of the study area in a period when no continuous in situ instrumental data is available. Additionally, the comparison of these results with the forensic data gathered in the 2005–2008 period, reveal that there is a coincidence between damaged buildings, buildings where extensometers register significant movements of cracks, and buildings deformation estimated from radar data. As a result, it has been demonstrated that the integration of DInSAR data into forensic analysis methodologies contributes to improve significantly the assessment of the damages of buildings affected by mining subsidence.

Atacama Desert and Puna de Atacama Region, Chile and Argentina, 1892 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carta jeogràfica del desierto i cordilleras de Atacama, levantada por la Comisión Esploradora de Atacama ; dibo. N. Boloña ; grabo A. Németh ; Lit. Alemana, Santiago. It was published by Dirección General de Obras Públicas. Seccion de Jeografia y Minas in 1892. Scale 1:1,000,000. Covers the Atacama Desert and Puna de Atacama region, Chile and Argentina. Map in Spanish. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'Mercator' projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, human settlements, roads, railroads, mines and mineral location, water lines, points of triangulation, territorial boundaries, shoreline features, ports, and more. Relief shown by hachures. Includes 5 insets depiciting mountain ranges entitled : Royeccion Vertical, vista Panorámica ; 2 plans entitled: Rada de Antofagasta -- Plano de la ciudad de Copiapó. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Tunisia and Libya, 1853 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: North Africa or Barbary : III Tunis and part of Tripoli, Society for the Diffusion of Useful Knowledge ; engraved by J. & C. Walker. This is map 3 of a 5 map set published by George Cox Jan. 1st, 1853. Scale [ca. 1:2,000,000]. Covers portions of Tunisia and Libya, and Malta. The image inside the map neatline is georeferenced to the surface of the earth and fit to a modified 'Europe Lambert Conformal Conic' projection with a central meridian of 12 degrees East. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, aqueducts, cities, villages and other human settlements, roads, trails, territorial boundaries, tribes, mines, and more. Relief shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection as part of the Open Collections Program at Harvard University project: Islamic Heritage Project. Maps selected for the project represent a range of regions, originators, ground condition dates, scales, and purposes. The Islamic Heritage Project consists of over 100,000 digitized pages from Harvard's collections of Islamic manuscripts and published materials. Supported by Prince Alwaleed Bin Talal and developed in association with the Prince Alwaleed Bin Talal Islamic Studies Program at Harvard University.

Geological character and mineral resources of south central Lake Erie /

"October 1982."

Sierras mexicaines, mines et mineurs.

Mode of access: Internet.

Analysis of priority pollutants at a primary zinc production facility /

Mode of access: Internet.

Food supply and raw materials in Japan : an index of the physical volume of production of foodstuffs, industrial crops, and minerals, 1894-1927 /

Published in 1929 under title: Agricultural and mineral production in Japan.

Agricultural and mineral production in Japan,

Mode of access: Internet.

Mineral resources and international strife.

Mode of access: Internet.

Proposed contract and specifications for the sinking of a shaft, etc.

Mode of access: Internet.

Bibliography of New Mexico geology and mineral technology.

First vol. (through 1950) compiled by M.R. Burks and J.H. Schilling; 1951-55 and 1956-60 by C.F. and J.H. Schilling: 1961-65 by T. Ray; 1966-70 by M.A. and H.H. Koehn; 1971-75 by J.R. Wright and J.A. Russell; 1976-80 by Dana M. Adkins-Heljeson and Candace L. Holts.

Technical paper.

a At head of title 453, 457-461, 463, 465- :U.S. Department of commerce ... Bureau of mines ...; 455, United States Department of commerce. Bureau of mines; 456, 462, 464, United States Department of commerce ... Bureau of mines ...