Los documentos de idoneidad técnica como potenciales incentivadotes de la industrialización de la construcción.

Los documentos de idoneidad técnica como potenciales incentivadotes de la industrialización de la construcción.

Theses ex logica metaphysica et ethica quas pro baccalaureatus gradu... D. Thoma Aquinate opitulante

El autor aparece en an. ms. después del "defendet"

Desarrollo de un sistema de digitalización y análisis de imágenes de microscopía para el diagnóstico de tuberculosis mediante inteligencia colectiva y gamificación

En este Trabajo de Fin de Grado se diseña, implementa y evalúa un sistema se digitalización de muestras de esputo basado en telefonía móvil e integrable con TuberSpot. Además, se proponen técnicas de procesamiento de imagen para el control de calidad del análisis y se implementa un mecanismo para evaluar la eficiencia de la inteligencia colectiva y la gamificación en este contexto. El sistema de adquisición propuesto utiliza smartphones, adaptadores móvil-microscopio y una aplicación Android. El protocolo de adquisición se ha diseñado conforme a un estudio realizado con personal médico cualificado. El control de calidad se basa en la inserción de bacilos simulados en las imágenes. Para la evaluación de eficiencia de TuberSpot se crea, en colaboración con médicos especialistas, un repositorio de imágenes en las que posición y número de bacilos quedan registrados.

La Institución Libre de Enseñanza y la arquitectura española de la Edad de Plata (1876-1936)

La tesis doctoral «La Institución Libre de Enseñanza y la arquitectura española de la Edad de Plata (1876-1936)» analiza las relaciones propiciadas por la ILE y la corriente cultural del institucionismo ―identificada desde los primeros años 70 del pasado siglo por el historiador Manuel Tuñón de Lara como crucial en la configuración de la cultura española contemporánea―, con la arquitectura de su tiempo en el marco histórico de la Restauración alfonsina y de la Segunda República. Lo hace desde los cuatro temas que configuran los grandes apartados en los que se estructura y articula el trabajo de investigación. El primero, el de la arquitectura de la escuela, a través del análisis de los escritos sobre la materia de los pedagogos Francisco Giner de los Ríos y Manuel Bartolomé Cossío y su papel en la materialización del edificio escolar. El segundo, el de la geografía madrileña de la ILE a través de un recorrido por las arquitecturas que acogieron su proyecto modernizador, confiado a la moral de la ciencia, a través de los centro por ella impulsados desde la Junta para Ampliación de Estudios e Investigaciones Científicas (JAE), como fueron la Residencia de Estudiantes y su grupo femenino de la Residencia de Señoritas, el Instituto Nacional de Física y Química, el Instituto-Escuela, el Centro de Estudios Históricos o el Instituto Cajal. El tercero, la renovación de la cultura arquitectónica española promovida a través de la política de pensiones de la JAE en el extranjero, de las actividades de extensión universitaria desarrolladas por la Residencia de Estudiantes en el ámbito de la arquitectura o por personas identificadas con su ideario. Y el cuarto, a través de la nueva valoración patrimonial de los monumentos arquitectónicos y de los paisajes españoles alentada por la práctica pedagógica del excursionismo y por los escritos de Francisco Giner de los Ríos y Manuel Bartolomé Cossío, que culmina con la promulgación de la Ley del Tesoro Artístico Nacional de 1933. El trabajo plantea una historia coral, donde tienen cabida arquitectos, pedagogos, políticos, historiadores del arte, críticos de arte y arquitectura de cuatro generaciones distintas: desde Ricardo Velázquez Bosco, coetáneo de Francisco Giner de los Ríos, a Arturo Sáenz de la Calzada, colegial de la Residencia de Estudiantes durante los años treinta y activo miembro de la Federación Universitaria Escolar, pasando por Carlos Velasco, Antonio Flórez Urdapilleta, Pablo Gutiérrez Moreno, Bernardo Giner de los Ríos, Leopoldo Torres Balbás, Carlos Arniches Moltó, Martín Domínguez Esteban, Fernando García Mercadal o Matilde Ucelay, en el caso de los arquitectos; Francisco Giner de los Ríos, Manuel Bartolomé Cossío, José Castillejo o Alberto Jiménez Fraud, entre los pedagogos; Segismundo Moret, Álvaro de Figueroa, Fernando de los Ríos o Marcelino Domingo, entre los políticos; Manuel Gómez-Moreno, Ricardo de Orueta o Emilio Camps Cazorla, entre los historiadores del arte; Javier de Winthuysen como jardinero o José Moreno Villa a través de su papel como crítico de arquitectura a favor del arte nuevo. Para ello, se ha partido del análisis y la interpretación de las arquitecturas de matriz institucionista a través de fuentes muy diversas, entre ellas un nutrido corpus de imágenes como complemento iconográfico fundamental en la articulación del discurso narrativo, que ha permitido situar a los temas analizados y sus protagonistas en su contexto histórico y disciplinar. Todo ello ha puesto de manifiesto el papel asumido por la Institución Libre de Enseñanza como un laboratorio de ideas y proyectos clave en la configuración de la cultura arquitectónica española del primer tercio del siglo XX. ABSTRACT The doctoral thesis «La Institución Libre de Enseñanza y la arquitectura española de la Edad de Plata (1876-1936)» analyzes the relationships fostered by the ILE and the cultural current «institucionismo» ―identified from the early '70s by the historian Manuel Tuñón de Lara as cardinal in shaping the contemporánea Spanish culture―, with the architecture of his time in the historical context of the Restoration and the Second Republic periods. This is done from the four themes that make up the major sections in which the research is structured and articulated. The first, the architecture of the school building, through the analysis of the writings on the subject of pedagogues Francisco Giner and Manuel Bartolomé Cossío and its role in the materialization of the school building. The second, the geography of the ILE in Madrid through a tour of the architectures that supported its modernizing project, entrusted to the moral of science, through the centers promoted by the Junta para Ampliación de Estudios e Investigaciones Científicas (JAE), as the Residencia de Estudiantes and its girls group Residencia de Señoritas, Instituto Nacional de Física y Química, Instituto-Escuela, Centro de Estudios Históricos or Instituto Cajal. The third, the renewal of the Spanish architectural culture promoted through JAE pension abroad, the university extension activities developed by the Residencia de Estudiantes in the field of architecture or people identified with its ideology. And the fourth, through new equity valuation of architectural monuments and the Spanish landscapes encouraged by the pedagogical practice of excursionism and by the writings of Francisco Giner de los Ríos and Manuel Bartolomé Cossío, culminating in the enactment of the Ley del Tesoro Artístico Nacional in 1933. The work raises a choral history, where have place architects, educators, politicians, art historians, art and architecture critics of four distinct generations: from Ricardo Velázquez Bosco, a contemporary of Francisco Giner, Arturo Sáenz de la Calzada, schoolboy student residence during the thirties and active member of the Federación Universitaria Escolar, through Carlos Velasco, Antonio Flórez Urdapilleta, Pablo Gutiérrez Moreno, Bernardo Giner, Leopoldo Torres Balbás, Carlos Arniches Moltó, Martín Domínguez Esteban, Fernando García Mercadal or Matilde Ucelay, in the case of architects; Francisco Giner, Manuel Bartolomé Cossío, José Castillejo and Alberto Jiménez Fraud, among teachers; Segismundo Moret, Álvaro de Figueroa, Fernando de los Ríos and Marcelino Domingo, among politicians; Manuel Gómez-Moreno, Ricardo de Orueta or Emilio Camps Cazorla, including art historians; Javier de Winthuysen as gardener and José Moreno Villa through his role as architecture critic for the new art. To do this, the origin point has been the analysis and interpretation of the «institucionista» architectures through a variety of sources, including a large corpus of iconographic images as a fundamental complement to the articulation of the narrative, which has allowed place the issues discussed and its protagonists in their historical context and discipline. This has highlighted the role played by the Institución Libre de Enseñanza as a laboratory of ideas and projects and key in shaping the Spanish architectural culture of the early twentieth century.

Análisis de rendimiento de la Liga de Fútbol Juvenil Nacional de las Islas Baleares en la Temporada 2013/2014

Este estudio trata de realizar un análisis de rendimiento, lo más detalladamente posible, de la temporada 2013/2014 de la Liga Nacional Juvenil de Fútbol de las Islas Baleares. Para ello, se han recogido los datos de las actas publicadas en la página web de la Federación de Futbol de las Islas Baleares contemplando distintas variables categorizadas en: “relacionadas con el resultado final”, donde comprobamos la importancia de marcar primero, jugar en casa, recibir más tarjetas que el rival, recibir penalti a favor y encajar gol en periodo crítico, “relacionadas con el tiempo”, donde analizamos cuando se producen los goles, las sustituciones y las tarjetas rojas, y por último, “relación entre niveles de los equipos”, donde examinamos las variables anteriores con los 3 primeros y 3 últimos clasificados de la primera vuelta. Finalmente, se dan unas posibles reflexiones sobre por qué suceden dichas variables.

RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs

On the basis of the sequence of the mitochondrial genome in the flowering plant Arabidopsis thaliana, RNA editing events were systematically investigated in the respective RNA population. A total of 456 C to U, but no U to C, conversions were identified exclusively in mRNAs, 441 in ORFs, 8 in introns, and 7 in leader and trailer sequences. No RNA editing was seen in any of the rRNAs or in several tRNAs investigated for potential mismatch corrections. RNA editing affects individual coding regions with frequencies varying between 0 and 18.9% of the codons. The predominance of RNA editing events in the first two codon positions is not related to translational decoding, because it is not correlated with codon usage. As a general effect, RNA editing increases the hydrophobicity of the coded mitochondrial proteins. Concerning the selection of RNA editing sites, little significant nucleotide preference is observed in their vicinity in comparison to unedited C residues. This sequence bias is, per se, not sufficient to specify individual C nucleotides in the total RNA population in Arabidopsis mitochondria.

In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation

Molecular mechanisms that regulate in situ activation of ryanodine receptors (RY) in different cells are poorly understood. Here we demonstrate that caffeine (10 mM) released Ca2+ from the endoplasmic reticulum (ER) in the form of small spikes in only 14% of cultured fura-2 loaded beta cells from ob/ob mice. Surprisingly, when forskolin, an activator of adenylyl cyclase was present, caffeine induced larger Ca2+ spikes in as many as 60% of the cells. Forskolin or the phosphodiesterase-resistant PKA activator Sp-cAMPS alone did not release Ca2+ from ER. 4-Chloro-3-ethylphenol (4-CEP), an agent that activates RYs in other cell systems, released Ca2+ from ER, giving rise to a slow and small increase in [Ca2+]i in beta cells. Prior exposure of cells to forskolin or caffeine (5 mM) qualitatively altered Ca2+ release by 4-CEP, giving rise to Ca2+ spikes. In glucose-stimulated beta cells forskolin induced Ca2+ spikes that were enhanced by 3,9-dimethylxanthine, an activator of RYs. Analysis of RNA from islets and insulin-secreting βTC-3-cells by RNase protection assay, using type-specific RY probes, revealed low-level expression of mRNA for the type 2 isoform of the receptor (RY2). We conclude that in situ activation of RY2 in beta cells requires cAMP-dependent phosphorylation, a process that recruits the receptor in a functionally operative form.

γ-Aminobutyric acid type A receptors modulate cAMP-mediated long-term potentiation and long-term depression at monosynaptic CA3–CA1 synapses

cAMP induces a protein-synthesis-dependent late phase of long-term potentiation (LTP) at CA3–CA1 synapses in acute hippocampal slices. Herein we report cAMP-mediated LTP and long-term depression (LTD) at monosynaptic CA3–CA1 cell pairs in organotypic hippocampal slice cultures. After bath application of the membrane-permeable cAMP analog adenosine 3′,5′-cyclic monophosphorothioate, Sp isomer (Sp-cAMPS), synaptic transmission was enhanced for at least 2 h. Consistent with previous findings, the late phase of LTP requires activation of cAMP-dependent protein kinase A and protein synthesis. There is also an early phase of LTP induced by cAMP; the early phase depends on protein kinase A but, in contrast to the later phase, does not require protein synthesis. In addition, the cAMP-induced LTP is associated with a reduction of paired-pulse facilitation, suggesting that presynaptic modification may be involved. Furthermore, we found that Sp-cAMPS induced LTD in slices pretreated with picrotoxin, a γ-aminobutyric acid type A (GABAA) receptor antagonist. This form of LTD depends on protein synthesis and protein phosphatase(s) and is accompanied by an increased ratio of failed synaptic transmission. These results suggest that GABAA receptors can modulate the effect of cAMP on synaptic transmission and thus determine the direction of synaptic plasticity.

B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.

Treatment of small resting B cells with soluble F(ab')2 fragments of anti-IgM, an analogue of T-independent type 2 antigens, induced activation characterized by proliferation and the expression of surface CD5. In contrast, B cells induced to proliferate in response to thymus-dependent inductive signals provided by either fixed activated T-helper 2 cells or soluble CD40 ligand-CD8 (CD40L) recombinant protein displayed elevated levels of CD23 (Fc epsilon II receptor) and no surface CD5. Treatment with anti-IgM and CD40L induced higher levels of proliferation and generated a single population of B cells coexpressing minimal amounts of CD5 and only a slight elevation of CD23. Anti-IgM- but not CD40L-mediated activation was highly sensitive to inhibition by cyclosporin A and FK520. Sp-cAMPS, an analogue of cAMP, augmented CD40L and suppressed surface IgM-mediated activation. Taken together these results are interpreted to mean that there is a single population of small resting B cells that can respond to either T-independent type 2 (surface IgM)- or T-dependent (CD40)-mediated activation. In response to different intracellular signals these cells are induced to enter alternative differentiation pathways.

La educación primaria en los campos de la provincia de Buenos Aires (1943-1955)

El artículo se ocupa de las políticas educativas dirigidas al ámbito rural. El objetivo es caracterizar las escuelas primarias en la campaña bonaerense y examinar las demandas, la legislación y los proyectos que tuvieron lugar en relación con dichas escuelas durante el primer Peronismo. Se utiliza una metodología cualitativa que toma como fuentes de información normativas, discursos, estadísticas y proyectos de reformas. Se concluye que, si bien las demandas materiales dieron lugar a planes que en la mayor parte de los casos se concretaron, las peticiones para atender a la especificidad de la escuela rural fueron más difíciles de efectivizar

Capacity-building through English language training to improve long-term resettlement success: A case study of the refugees along the Thailand-Burma border

Achieving long-term resettlement success is a challenge for many refugees seeking to restart their lives after displacement and being uprooted from their lives. Refugees must deal with finding employment, integrating into a society immensely different from what they have known their whole lives, and starting over from scratch. Learning a new language enables refugees to progress towards integration and long-term resettlement success, however, resettled refugees face a multitude of barriers in the U.S. to accessing language classes and attaining English proficiency. This study seeks to bridge this problem by exploring the possibilities of implementing a standardized language training program in the refugee camps to better prepare refugees for resettlement. A case study of the refugees along the Thai-Burma border demonstrated the significance of learning English in the camps on eventual English proficiency as well as the need for increased partnerships to overcome the barriers of lack of motivation and lack of funding. The author explores the possibilities of implementing a language training program in the camps by determining need, interest, barriers, and perceptions through the use of interviews, surveys, and focus groups of camp refugees, resettled refugees, and key organizational representatives. The significance of these results offers the possibility of leveraging and unlocking resettlement as a durable solution for more of the world's refugees in protracted situations.

New Middle East Cold War: Saudi Arabia and Iran's Rivalry

The competing powers of Saudi Arabia and Iran continue to redress and reverse the strategic imbalance and direction of the Middle East’s regional politics. The 1979 Iranian Revolution catapulted these two states into an embittered rivalry. The fall of Saddam Hussein following the 2003 U.S. led invasion, the establishment of a Shi’ite Iraq and the 2011 Arab Uprisings have further inflamed tensions between Saudi Arabia and Iran. Iran and Saudi Arabia have not confronted each other militarily, but rather have divided the region into two armed camps on the basis of political and religious ideology in seeking regional allies and promulgating sectarianism as they continue to exploit the region’s weak states in a series of proxy wars ranging from conflicts in Iraq to Lebanon. The Saudi-Iranian strategic and geopolitical rivalry is further complicated by a religious and ideological rivalry, as tensions represent two opposing aspirations for Islamic leadership with two vastly differing political systems. The conflict is between Saudi Arabia, representing Sunni Islam via Wahhabism, and Iran, representing Shi’ite Islam through Khomeinism. The nature of the Saudi-Iranian rivalry has led many Middle East experts to identify their rivalry as a “New Middle East Cold War.” The Saudi-Iranian rivalry has important implications for regional stability and U.S. national security interests. Therefore, this thesis seeks to address the question: Is a cold war framework applicable when analyzing the Saudi Arabian and Iranian relationship?

Fluorescent Biological Aerosol Particles in Coastal Canada and the Link to Atmospheric Ice Nuclei

Bioaerosols are a subgroup of atmospheric aerosols and are often linked to the spread of human, animal and plant diseases. Bioaerosols also may play an indirect effect on environmental processes, including the formation of precipitation and alteration of the global climate through their role as nuclei for cloud droplet formation. Several types of biological organisms (e.g., fungi and bacteria) have been shown to be effective ice nuclei (IN) and cloud condensation nuclei (CCN). During 21 days in August 2013 we participated in a collaborative international campaign at a rural, coastal site near the village of Ucluelet on the west coast of Vancouver Island, British Columbia, Canada. The experiments were conducted as part of the NETCARE project (the NETwork on Climate and Aerosols: Addressing Key Uncertainties in Remote Canadian Environments), in part to examine cloud nuclei properties of marine aerosol. The study was conducted from a mobile trailer located approximately 100 m from the coast. A suite of aerosol instrumentation was operated for approximately one month. Key instruments utilized as a part of this thesis include the wideband integrated bioaerosol sensor (WIBS-4A) and the multiple orifice uniform deposition impactor (MOUDI) coupled with an off-line droplet freezing technique (DFT) for the measurement of ice nucleation activity of particles in immersion mode. The WIBS measures the concentration and properties of individual fluorescent particles suspended in the air, which can serve as a proxy for airborne biological particle content. Particles shown to be fluorescent by the WIBS instrument were divided into seven categories based on the pattern of fluorescence each particle exhibited in the three fluorescent channels. Results of the WIBS analysis show that the fluorescent particle concentration in the region correlated well with IN number. The fluorescent particle concentration correlated well with the number of particles shown to be ice active as a function of both particle size and freezing temperature. Correlations involving marine aerosols and marine biological activity indicate that the majority of IN measured at the coastal site likely are not from have marine sources.

Denver Bible Institute under the leadership of Clifton L. Fowler

"Denver Bible Institute, founded in 1914, became a Bible College in 1945 and subsequently renamed Rockmont College..."

Looking Back: A Granddaughter's Quest for Redemption and Understanding

On December 7th, 1941 Japan attacked Pearl Harbor in Hawaii. This event signaled the beginning of America's involvement in World War II. It also signaled the beginning of a change of life for the Japanese living in the United States. Following the attack, 120,000 persons of Japanese ancestry were placed in ten internment camps across the United States. Two-thirds of those interned were American citizens, including my grandmother. The fact that these American citizens were treated as prisoners in their own country had a devastating effect on the relationships of those interned and the generations of Japanese Americans that followed. This essay recounts my grandma's experience and explores how her internment changed her life and the lives of her descendants.