Metabolômica, uma abordagem otimizada para exploração da biodiversidade brasileira: estado da arte, perspectivas e desafios

Brazilian biodiversity is a colossal source of secondary metabolites with remarkable structural features, which are valuable in further biodiscovery studies. In order to fully understand the relations and interactions of a living system with its surroundings, efforts in natural product chemistry are directed toward the challenge of detecting and identifying all the molecular components present in complex samples. It is plausible that this endeavor was born out of recent technological sophistication in secondary metabolite identification with sensitive spectroscopic instruments (MS and NMR) and higher resolving power of chromatographic systems, which allow a decrease in the amount of required sample and time to acquire data. Nevertheless, the escalation of data acquired in these analyses must be sorted with statistical and multi-way tools in order to select key information. Chromatography is also of paramount importance, more so when selected compounds need to be isolated for further investigation. However, in the course of pursuing a greener environment, new policies, with an aim to decrease the use of energy and solvents, are being developed and incorporated into analytical methods. Metabolomics could be an effective tool to answer questions on how living organisms in our huge biodiversity work and interact with their surroundings while also being strategic to the development of high value bio-derived products, such as phytotherapeutics and nutraceuticals. The incorporation of proper phytotherapeutics in the so-called Brazilian Unified Health System is considered an important factor for the urgent improvement and expansion of the Brazilian national health system. Furthermore, this approach could have a positive impact on the international interest toward scientific research developed in Brazil as well as the development of high value bio-derived products, which appear as an interesting economic opportunity in national and global markets. Thus, this study attempts to highlight the recent advances in analytical tools used in detection of secondary metabolites, which can be useful as bioproducts. It also emphasizes the potential avenues to be explored in Brazilian biodiversity, known for its rich chemical diversity.

Análise de robustez de estações da rede GNSS-SP

Currently, the need of reliable coordinates has been one of the main objectives of the scientific and practice community. Thus, the robustness analysis of a geodetic network, aims, at analyzing if the network is robust or not, based on the maximum undetectable errors. The network will be robust if the influence of these errors is small, otherwise it is weak, or not robust. This analysis is performed with the merger of two techniques, one which deals with the statistical analysis of reliability and the other one with the geometric strength analysis. The reliability analysis will provide the maximum error that cannot be detected by tests, after the adjustment. After finding these errors, the geometric strength analysis will determine the potential strain that the network will have, based on these errors. It is emphasized that the robustness analysis doesn't depend of the datum, reflecting only the geometry of the network and the accuracy of the observations (VANÌCEK et al., 2001). Therefore, this work aims at contributing to the scientific research on geodetic networks, checking the same, based on their geometry and observations.

Entre a expressão e a técnica: a terminologia do professor de canto - um estudo de caso em pedagogia vocal de canto erudito e popular no eixo Rio-São Paulo

Pós-graduação em Música - IA

Predição de ganho genético utilizando índices de seleção em linhagens de milho

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Entre a fábrica e a senzala: um estudo sobre o cotidiano dos africanos livres na Real Fábrica de Ferro São João do Ipanema - Sorocaba - SP (1840-1870)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Mapeamento das evidências das revisões sistemáticas do Grupo Anestesiologia da Colaboração Cochrane: entendendo seu valor para a prática clínica

Pós-graduação em Anestesiologia - FMB

A organização do conhecimento na dinâmica da pesquisa em artigos da literatura científica da Brapci

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Antimicrobial activity of natural products against Helicobacter pylori: a review

Throughout the genetic and physiological evolution of microorganisms, the microbiological sciences have been expanding the introduction of new therapeutic trials against microbial diseases. Special attention has been paid to the bacterium Helicobacter pylori, which induces gastric infections capable of causing damage, ranging from acute and chronic gastritis to the development of gastric cancer and death. The use of compounds with natural origins has gained popularity in scientific research focused on drug innovation against H. pylori because of their broad flexibility and low toxicity. The aim of this study was to describe the use of natural products against H. pylori in order to clarify important parameters for related fields. The study demonstrated the vast therapeutic possibilities for compounds originating from natural sources and revealed the need for innovations from future investigations to expand the therapeutic arsenal in the fight against H. pylori infection.

Artemídia preferente: fenômeno jogar & ler nas histórias em quadrinhos interativas (HQI) com os games de RPG

This artistic-scientific process aims to innovate the concept of Interactive Comics by adding them into the concept of RPG games and Single-Adventures. To make it properly done, there will be some issues about Interactivity, history of the Comic Strip and Mangas, and their techniques of use. Also, there will be other issues involving Electronic Comics and Interactive Comics, in addition to the concept of the RPG games and Single-Adventures, so that the reader of this paper could understand the practical result of every issue combined into one. The identification of these issues is made from a bibliographic and iconographic research, and it will also be displayed throughout the content. Some decisions will be thrown along this paper for the reader to decide and, therefore, understand the Interactivity process in a better way. The combined issues’ result will be presented in my interactive website, http://a3studios.com.br/iss/home (address not final) or http://amstarproductions.net (final address), where the readers will have to experience the “Play&Read” phenomenon. Furthermore, this work is inserted in the line of the research Artistic Processes and Procedures of the Department of Fine Arts from the Art Institute of UNESP, whose methodology used was the Freinet Educational Cybernetics, developed in the research group Media Arts and Videoclip leaded by the leading advisor for this Final Course Work. The result and discussion of artistic and scientific research were reported in monographs such as this that I present, with the following versions: PDF version for dissemination in the virtual repository of the Institute of Arts’ Library; hardcover version for physical collection at the Library of Institute of Arts; The Printed Version for the board of examiners; and an appropriated template version for submission to International Scientific Congress in the area of Arts.

HQtrônica: atividade programada e curso de extensão

This Final Course Work’s main subject comes from a study made on my previous Final Course Work titled “Artemídia Preferente: Fenômeno ‘Jogar&Ler’ nas Histórias em Quadrinhos Interativas (HQI) com os games do RPG”, and it is fed by the shortage of Electronical Comic publications, classes, courses and activities that could suit for educational purposes and experiences for a capable kind of audience to learn it and do it. Specific issues about Electronic Comic will be presented, based on Célestin Freinet’s Pedagogy, on some books about Methodology and on the Brazilian Curriculum Guidelines required for graduation. After that, a Lesson Plan will be developed for a 14 year-old-or-older kind of audience where they will be capable of making their own Electronic Comic, being it educational-themed or not. This study also cares about the participants’ influences on their lives to be completed. Furthermore, this work is inserted in the line of the research “Artistic Processes and Procedures” of the Department of Fine Arts from the Art Institute of UNESP, whose methodology used was the Freinet Educational Cybernetics, developed in the research group “Media Arts and Videoclip” leaded by the leading advisor for this Final Course Work. The result and discussion of artistic and scientific research were reported in monographs such as this that I present, with the following versions: PDF version for dissemination in the virtual repository of the Institute of Art’s Library; hardcover version for physical collection at the Institute of Art’s Library; the printed version for the board of examiners, and an appropriated template version for submission to the International Scientific Congress in the area of Arts.

Caracterização de diodos tipo Schottky fabricados com poli-o-metoxianilina em diversas temperaturas

Technological advances achieved during the twentieth century strongly boosted the scientific research in the area of condensed matter physics, especially in the study and development of new semiconductor materials. In the segment, the development of semiconducting polymers for application in electronic devices promotes the field of organic electronics...(Complete abstract click electronic access below)

Análise comparativa de softwares de simulação de onda de cheia e corridas de massa

This scientific research aimed at presenting a comparative analysis of softwares used to represent the processes of flood wave and debris flow. For this, a literature review was performed on these processes and on simulation models used to represent them. Then, a research on scientific database and developers’ websites was performed to identify the softwares used to simulate these processes. This step was performed based on specific criteria such as the type of simulation performed by the software, its practical applications and a user friendly interface. A free distribution and totally functional software was chosen and its simulation mechanisms were tested through a simulation exercise and the results interpreted based on data on measured in the Basin of Ribeirão Marins section Monjolinho located in Piracicaba - SP. With respect to the processes, it was sought to present the dynamics, constraints, parameters and variables used to understand them and for the simulation models were presented the conceptual aspects of mathematical modeling including the steps of the simulation process and the different types of simulation models used to represent them. In total, 20 softwares were identified, and the software object of analysis was the ABC 6 that performs simulation of flood wave. Through the simulation exercise, it was observed that were presented overestimated values of flow compared to measured data in the basin. For both hypotheses were raised about the causes of the discrepancy between the observed and simulated flow. It has been concluded that the simulation process consisted of a complex procedure where generalizations, misrepresentations and simplifications may occur due to the data used and the method adopted, but it is a useful tool in planning and decision making in various types of studies and environmental projects

Artemídia escrevente: a caligrafia entre a arte e o design

The term “writing media art” expresses an artisticscientific process performed in the Art-Science Communication interface presented as Final Paper in Visual Arts baccalaureate modality. The first part gathers, in artistic-scientific research, a historical overview of the relation between image and writing, which its main focus is calligraphy and its different expressions in art and design, including their interrelations. The identification is made from bibliographical and iconographical survey, both printed and virtual materials. This approach involves the selection of authors’ statements and comments in order to offer a deeper historical basis, since it comes to facts and events. The second part relates to the set of works produced during the four-year period of the Visual Arts course, including a reflection about the creation process and all that surrounds it – influences, memories, visions etc. – to finally establish a connection between all these elements in order to make clear this incredible web of creation. This work is inserted in the line of research “Artistic Processes and Procedures” of the Department of Fine Arts of the Art Institute of UNESP and describes: creative process, production and influences. The methodology used was Freinetiana Educational Cybernetics, developed in the research group “Art media and Videoclip”, whose leading advisor is the one from this Final Paper. The result and discussion of the artistic-scientific research were reported in monography in the following versions: PDF File repository for dissemination in the virtual library of the Institute of Arts; hardcover version for physical collection in the Library of the Institute of Arts; paper version for the committee; template version appropriate for submission to International Scientific Congress in the area of Arts

A inserção da Família nos serviços de Saúde Mental: uma revisão sistemática da Literatura

It is a systematic literature review, wich aimed to analyze documents, as is the inclusion of the family in Mental Health Services. To do so was based on a literature in the database of the Latin American and Caribbean Health Sciences (LILACS). And the documents were selected from the question which funded the research to evaluate the contribution of scientific research published in journals in the period 2000 to 2011. Data analysis reveals that the government's efforts in having the family as an ally, not a recent phenomenon. But this is a process that depends not only on government, also depends on the professionals involved and of their own families, and other factors. It is concluded that much remains to be done, both in terms of research for the topic, the actions in the reality of such a process

O discurso do uso de animais nas pesquisas de Educação Física

It is possible in many countries, perhaps all, there is business groups of pharmaceuticals industry, cosmetics together with the universities that use animals in scientific research and testing for the creation of new products and medicines. Currently is growing discussion about standards and criteria for the use of these animals (guinea pigs) and also increases the number of debates on ethical issues in research with animal models. This research seeks to portray the reality of the use of animals in scientific research academic at the University, specifically to research in physical education, as it has used animals in the areas of Physiology of Sport and Physical Activity, Nutrition for Athletes, among others. Initially is shown the pre-reflection, exposing the laws governing the subject, treating the animal experimentation with regard to its history and the issues of speciesism and the methodological mistake. It reveals what it is and as is the use of animals in education and the inability of the student to change that reality, to refuse to participate in the cruel activity, and even they are aware of their rights as in the case of the withdrawal of consciousness. Presents researchers and universities not use animals and ends the pre-debate showing Who is really the most animal research at the university by providing alternatives for them. We conducted a literature survey on animal experimentation, research universities, and alternative methods. The following is the phenomenon in understanding and awareness of the researchers who use animals in their research, conducting a phenomenological analysis of his speeches, revealing the meanings of their animal research. The focus of this study is, therefore, the analysis of discourses of researchers who carried out research using animal experiments (guinea pigs). The phenomenon of understanding of the researchers about their research is made clear... (Complete abstract click ectronic access below)