Thomas, Howard, O'Neal, Don and Ghertman, Michael (Eds). Strategy, structure and style. Chichester: John Wiley, 1997

Book review

Mechanism of attenuation of angiotensin-II-induced protein degradation by insulin-like growth factor-I (IGF-I)

Insulin-like growth factor-I (IGF-I) has been shown to attenuate protein degradation in murine myotubes induced by angiotensin II through downregulation of the ubiquitin-proteasome pathway, although the mechanism is not known. Angiotensin II is known to upregulate this pathway through a cellular signalling mechanism involving release of arachidonic acid, activation of protein kinase Cα (PKCα), degradation of inhibitor-κB (I-κB) and nuclear migration of nuclear factor-κB (NF-κB), and all of these events were attenuated by IGF-I (13.2 nM). Induction of the ubiquitin-proteasome pathway has been linked to activation of the RNA-activated protein kinase (PKR), since an inhibitor of PKR attenuated proteasome expression and activity in response to angiotensin II and prevented the decrease in the myofibrillar protein myosin. Angiotensin II induced phosphorylation of PKR and of the eukaryotic initiation factor-2 (eIF2) on the α-subunit, and this was attenuated by IGF-I, by induction of the expression of protein phosphatase 1, which dephosphorylates PKR. Release of arachidonic acid and activation of PKCα by angiotensin II were attenuated by an inhibitor of PKR and IGF-I, and the effect was reversed by Salubrinal (15 μM), an inhibitor of eIF2α dephosphorylation, as was activation of PKCα. In addition myotubes transfected with a dominant-negative PKR (PKRΔ6) showed no release of arachidonate in response to Ang II, and no activation of PKCα. These results suggest that phosphorylation of PKR by angiotensin II was responsible for the activation of the PLA2/PKC pathway leading to activation of NF-κB and that IGF-I attenuates protein degradation due to an inhibitory effect on activation of PKR. © 2007 Elsevier Inc. All rights reserved.

In My Opinion: Michael E. Hurst: July 8, 1931 - March 22, 2001

My reflections of Michael E. Hurst are a much more modest enterprise than a memoir or biography. My portrait of him will only portray the images I observed and remember: As he was an adult when I met him, it is far from a complete picture of him. I was his academic dean, fellow professor, and friend. While fame has eluded most people I know. Hurst was the exception: everyone in the food service industry knew him.

Guantánamo and Cuban Nationalism, Lecture by Michael E. Parmly

This flyer promotes the event "Guantánamo and Cuban Nationalism, Lecture by Michael E. Parmly", cosponsored by the FlU Latin American and Caribbean Center.

U.S.-Cuba: Is There Room for Two Nationalisms So Close to Each Other? Lecture by Michael E. Parmly

This flyer promotes the event "U.S.-Cuba: Is There Room for Two Nationalisms So Close to Each Other? Lecture by Michael E. Parmly".

Intro 475 with Councilman Michael DeMarco

General note: Title and date provided by Bettye Lane.

La valeur monde : traduction et mondialisation dans Anil's Ghost de Michael Ondaatje

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

La valeur monde : traduction et mondialisation dans Anil's Ghost de Michael Ondaatje

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.