Vista de la puerta de entrada de la fortaleza de Xativa [ [Material gráfico]= Vue de la porte d'entrèe de la forteresse de Xativa, et d'une partie de la ville de St. Philippe = View of the great gate of the fortress of Xativa, and of a part of the town of St. Philip

Datos de publicación tomados de la obra a la que pertenece

Histoire naturelle des animaux sans vertèbres ... Troisieme Edition

3

Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity

Staphylococcus aureus produces a virulence factor, protein A (SpA), that contains five homologous Ig-binding domains. The interactions of SpA with the Fab region of membrane-anchored Igs can stimulate a large fraction of B cells, contributing to lymphocyte clonal selection. To understand the molecular basis for this activity, we have solved the crystal structure of the complex between domain D of SpA and the Fab fragment of a human IgM antibody to 2.7-Å resolution. In the complex, helices II and III of domain D interact with the variable region of the Fab heavy chain (VH) through framework residues, without the involvement of the hypervariable regions implicated in antigen recognition. The contact residues are highly conserved in human VH3 antibodies but not in other families. The contact residues from domain D also are conserved among all SpA Ig-binding domains, suggesting that each could bind in a similar manner. Features of this interaction parallel those reported for staphylococcal enterotoxins that are superantigens for many T cells. The structural homology between Ig VH regions and the T-cell receptor Vβ regions facilitates their comparison, and both types of interactions involve lymphocyte receptor surface remote from the antigen binding site. However, T-cell superantigens reportedly interact through hydrogen bonds with T-cell receptor Vβ backbone atoms in a primary sequence-independent manner, whereas SpA relies on a sequence-restricted conformational binding with residue side chains, suggesting that this common bacterial pathogen has adopted distinct molecular recognition strategies for affecting large sets of B and T lymphocytes.

Erasmus Darwin e os seres vivos: concepções de \'evolução\' e herança

Erasmus Darwin (1731-1802) apresentou suas ideias evolutivas principalmente no fim do século XVIII. No entanto, elas não foram consideradas na época. Seu neto, Charles Darwin (1809-1882), na 6ª edição do Origin of species as avaliou de modo negativo, comparando-as às concepções equivocadas de Lamarck. O objetivo desta dissertação é inicialmente, descrever as concepções de hereditariedade e evolução de Erasmus, considerando o contexto de sua época. Além disso, procura esclarecer se o tratamento recebido se deveu a uma proposta fraca ou se ela mereceria uma maior consideração. Esta dissertação contém uma Introdução e quatro capítulos. O Capítulo 1 discute a vida, trabalhos e contexto em que Erasmus apresentou suas ideias. O Capítulo 2 lida com as concepções de herança e evolução presentes em Zoonomia. O Capítulo 3 discute sobre as concepções de Erasmus sobre a transformação das espécies nas plantas. O Capítulo 4 compara as concepções evolutivas de Erasmus com as de Lamarck. O Capítulo 5 procura responder às perguntas colocadas no início desta pesquisa e apresenta algumas considerações finais sobre o assunto discutido. Esta pesquisa leva à conclusão de que a transmutação das espécies não era o principal interesse de Erasmus. Ele não ofereceu uma fundamentação empírica para suas ideias. Este fato, juntamente com a situação sócio-político-religiosa da época, muito provavelmente contribuiu para a recepção sofrida. Além disso, embora existam algumas semelhanças entre as propostas de Erasmus e Lamarck, existem também grandes diferenças tais como a abrangência da pesquisa, o espaço dedicado à discussão das ideias, a fundamentação oferecida, dentre outras. Erasmus não propôs uma teoria coerente lidando com desde a origem da vida até o aparecimento do homem como Lamarck. Ele somente apresentou algumas ideias a esse respeito em obras dedicadas a outros assuntos.

L' Europe galante: ballet : représenté en l'an 1697 par l'Academie royale de musique

de la composition de Monsieur Campra, maître de musique de la chapelle du Roy ; les paroles de cette piece sont de Monsieur de La Motte, de l'Academie françoise.

Histoire naturelle des animaux sans vertèbres ... précédée d'une introduction offrant la détermination des caractères essentiels de l'animal, sa distinction du végétal et des autres corps naturels, enfin, l'exposition des principes fondamentaux de la zoologie.

3 & 5

Histoire naturelle des animaux sans vertèbres ... précédée d'une introduction offrant la détermination des caractères essentiels de l'animal, sa distinction du végétal et des autres corps naturels, enfin, l'exposition des principes fondamentaux de la zoologie.

7

Histoire naturelle des animaux sans vertèbres ... précédée d'une introduction offrant la détermination des caractères essentiels de l'animal, sa distinction du végétal et des autres corps naturels, enfin, l'exposition des principes fondamentaux de la zoologie.

6

Histoire naturelle des animaux sans vertèbres ... Troisieme Edition

1

Memoire pour servir de reponse a l'ecrit des reflections mal et sans fondement refléchiés par les res p[èr]es Jesuistes (sic) du College de Quebec remis pars le R[everen]d J. Duparc superieur dud[it] college a un Ecclesiastique du Seminaire de Quebec le 8 avril 1728 : manuscript, [17--]

Reply to Jean-Baptiste Du Parc's Reflexions sur la contestation survenus entre messieurs du chapitre de Quebec concerning church administration in Quebec.

India & South Asia, 1752 (Image 1 of 2) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte de l'Inde : dressée pour la Compagnie des Indes, par le Sr. d'Anville, Sécrétaire de S.A.S. Mgr. le Duc d'Orleans ; [engraved by] Guill.' de-la-Haye. It was published by Jean Baptiste Bourguignon d'Anville in November 1752. Scale [ca. 1:3,100,000]. This layer is image 1 of 2 total images of the two sheet source map, representing the northern portion of the map. Covers India and portions of South Asia. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Kalianpur 1975 India Zone III projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown pictorially. Includes insets: Negraïs -- Rivière d'Aracan -- Riv. de Sirian -- Archipel de Merghi -- Environs de Junk Selon -- Environs d'Ashem -- Entréé du Gange -- Environs de Goa. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

India & South Asia, 1752 (Image 2 of 2) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte de l'Inde : dressée pour la Compagnie des Indes, par le Sr. d'Anville, Sécrétaire de S.A.S. Mgr. le Duc d'Orleans ; [engraved by] Guill.' de-la-Haye. It was published by Jean Baptiste Bourguignon d'Anville in November 1752. Scale [ca. 1:3,100,000]. This layer is image 2 of 2 total images of the two sheet source map, representing the southern portion of the map. Covers India and portions of South Asia. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Kalianpur 1975 India Zone III projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown pictorially. Includes insets: Negraïs -- Rivière d'Aracan -- Riv. de Sirian -- Archipel de Merghi -- Environs de Junk Selon -- Environs d'Ashem -- Entréé du Gange -- Environs de Goa. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.