Types of discrepancy in Millennium Development Goal indicator values and measures for statistical reconciliation: Overall framework and implementation in selected thematic areas and indicators

Includes bibliography.

Approach to prophylactic measures for central venous catheter-related infections in hemodialysis: A critical review

Vascular access is the major risk factor for bacteremia, hospitalization, and mortality among hemodialysis (HD) patients. The type of vascular access most associated with bloodstream infection is central venous catheter (CVC). The incidence of catheter-related bacteremia ranges between 0.6 and 6.5 episodes per 1000 catheter days and increases linearly with the duration of catheter use. Given the high prevalence of CVC use and its direct association with catheter-related bacteremia, which adversely impacts morbidity and mortality rates and costs among HD patients, several prevention measures aimed at reducing the rates of CVC-related infections have been proposed and implemented. As a result, a large number of clinical trials, systematic reviews, and meta-analyses have been conducted in order to assess the effectiveness, clinical applicability, and long-term adverse effects of such measures. In the following article, prophylactic measures against CVC-related infections in HD patients and their possible advantages and limitations will be discussed, and the more recent literature on clinical experience with prophylactic antimicrobial lock therapy in HD CVCs will be reviewed.

Efficacy of sulfadoxine plus trimethoprim compared to management measures for the control of Eimeria parasitism in naturally infected and clinically asymptomatic sheep that were maintained in a feedlot

The efficacy of sulfadoxine + trimethoprim in comparison to management measures for the control of Eimeria parasitism was studied in naturally infected sheep that were raised in a feedlot and were clinically asymptomatic for eimeriosis. Weight gain was also evaluated in these animals. The following groups were formed with 15 animals/group: TO!, control animals that received saline solution and maintenance of the same management measures that were performed before the study; T02, animals that received two intramuscular doses of sulfadoxine (20 mg/kg) + trimethoprim (4 mg/kg) with a 14-day interval; T03, sheep that received two intramuscular doses of sulfadoxine (20 mg/kg) + trimethoprim (4 mg/kg) with a 14-day interval plus management measures (wood shaving bedding was changed every Monday, and 30g of ammonium sulfate were applied to the bedding and other facilities were performed every Thursday, 10 mL/20 L of water); and T04, animals that received only the management measures described for the previous group. The highest efficacy rates (arithmetic mean) for the T02 group (sulfadoxine + trimethoprim at days 0 and 14) were 21.04% and 21.98% on the 14th and 28th days after the first treatment (DAFT), respectively. However, the treatment showed efficacy rates below 17% and was totally ineffective from the 70th DAFT to the end of the study. In both the T03 (chemical treatment+ management) and T04 (management only) groups, a significant (P <= 0.05) reduction of oocyst shedding per gram of feces was observed in the animals from the 14th DAFT in comparison to the control group; however, an efficacy rate above 90% was observed from the 28th DAFT. Animals belonging to the T02, T03 and T04 groups presented with alterations in weight gain of 0.57 kg, 4.30 kg and 4.53 kg, respectively, in comparison with the control animals (T01) throughout the 91-day study period. Thus, it is possible to conclude that the two-dose sulfadoxine + trimethoprim treatment, given with a 14-day interval, had little no effect on the oocyst shedding. Moreover, the adopted management measures were enough to cause a significant decrease in the animal parasite loads. (C) 2013 Published by Elsevier B.V.

Quantitative measures of lambs fed hydrolyzed sugarcane under aerobic and anaerobic conditions

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Behavioral measures to reduce non-adherence in renal transplant recipients: a prospective randomized controlled trial

Solid-organ transplant recipients present a high rate of non-adherence to drug treatment. Few interventional studies have included approaches aimed at increasing adherence. The objective of this study was to evaluate the impact of an educational and behavioral strategy on treatment adherence of kidney transplant recipients. In a randomized prospective study, incident renal transplant patients (n = 111) were divided into two groups: control group (received usual transplant patient education) and treatment group (usual transplant patient education plus ten additional weekly 30-min education/counseling sessions about immunosuppressive drugs and behavioral changes). Treatment adherence was assessed using ITAS adherence questionnaire after 3 months. Renal function at 3, 6, and 12 months, and the incidence of transplant rejection were evaluated. The non-adherence rates were 46.4 and 14.5 % in the control and treatment groups (p = 0.001), respectively. The relative risk for non-adherence was 2.59 times (CI 1.38-4.88) higher in the control group. Multivariate analysis demonstrated a 5.84 times (CI 1.8-18.8, p = 0.003) higher risk of non-adherence in the control group. There were no differences in renal function and rejection rates between groups. A behavioral and educational strategy addressing the patient's perceptions and knowledge about the anti-rejection drugs significantly improved the short-term adherence to immunosuppressive therapy.

Knowledge of nursing undergraduate students about the use of contact precautions measures

To assess knowledge of nursing undergraduate students about the use of contact precautions. Methodology. There were 106 nursing undergraduate students from three universities within the state of Sao Paulo. The data collection was done between April and May 2012. A questionnaire was elaborated with questions assessing knowledge regarding contact precautions. The data were submitted to statistical procedures in the package MINITAB version 16. The knowledge were rated as adequate, partially adequate and inadequate. Results. There was a predominance of females (86%) and age group between 20 and 29 years (70%). Regarding the definition of contact precaution of diseases in which these measures are used, undergraduate’s knowledge was partially adequate (92% and 44%, respectively). The knowledge was considered adequate for the preventive measures used during assistance (86%). As difficulties mentioned in the use of these measures were discomfort, lack of material, personnel and time. Conclusion. Although undergraduate students know what measures to be used in contact precaution, they do not have adequate knowledge about which diseases they should use them. The three participating universities should reflect on the quality of training for nursing students regarding biosecurity and contact precautions.

Tobacco in adolescence: importance to knowledge the health hazards and preventive measures

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Anxiolytic-Like Property of Risperidone and Olanzapine as Examined in Multiple Measures of Fear in Rats

Atypical antipsychotics are also used in the treatment of anxiety-related disorders. Clinical and preclinical evidence regarding their intrinsic anxiolytic efficacy has been mixed. In this study, we examined the potential anxiolytic-like effects of risperidone and olanzapine, and compared them with haloperidol, chlordiazepoxide (a prototype of sedative–anxiolytic drug) or citalopram (a selective serotonin reuptake inhibitor). We used a composite of two-way avoidance conditioning and acoustic startle reflex model and examined the effects of drug treatments during the acquisition phase (Experiment 1) or extinction phase (Experiments 2 and 3) on multiple measures of conditioned and unconditioned fear/anxiety-like responses. In Experiment 4, we further compared risperidone, olanzapine, haloperidol, citalopram and chlordiazepoxide in a standard elevated plus maze test. Results revealed three distinct anxiolytic-like profiles associated with risperidone, olanzapine and chlordiazepoxide. Risperidone, especially at 1.0 mg/kg, significantly decreased the number of avoidance responses, 22 kHz ultrasonic vocalization, avoidance conditioning-induced hyperthermia and startle reactivity, but did not affect defecations or time spent on the open arms. Olanzapine (2.0 mg/kg, sc) significantly decreased the number of avoidance responses, 22 kHz vocalization and amount of defecations, but it did not inhibit startle reactivity and time spent on the open arms. Chlordiazepoxide (10 mg/kg, ip) significantly decreased the number of 22 kHz vocalization, avoidance conditioning-induced hyperthermia and amount of defecations, and increased time spent on the open arms, but did not decrease avoidance responses or startle reactivity. Haloperidol and citalopram did not display any anxiolytic-like property in these tests. The results highlight the importance of using multiple measures of fear-related responses to delineate behavioral profiles of psychotherapeutic drugs.

Diatoms and Tonsteins as Paleoenvironrnental and Paleodepositional Indicators in a Miocene Coal Bed, Costa Rica

Fresh-water diatoms are present in coal, and tonsteins (altered volcanic ash) are interbedded with the coal, in the Miocene Venado Formation on the southwest margin of the Limon Basin, in Provincia Alajuela, northern Costa Rica. The Venado Formation is composed of more than 300 m of mudstone, siltstone, sandstone, limestone, volcaniclastics, and coal beds. The coal beds are of unknown lateral extent and mainly occur in the middle part of the formation. The Pataste coal bed occurs near the middle of the formation and is divided into three parts by two tonstein layers. The abundance of biogenic opaline material (diatoms) in the coal is believed to be a direct response to an influx of silica from volcanic tuffs that Later altered to the tonsteins. Diatoms are a useful microscopic tool for identifying the depositional environments of the Pataste coal deposit. The diatoms identified include Aulacosira ambigua, Pinnularia sp., Eunotia spp., and Achnanthes exigua, among others. The abundance of Aulacosira arnbigua suggests that an open-water lacustrine environment was present locally. Achnanthes exigua and the remaining diatom species are benthic forms that lived in shallow fresh-water to slightly acidic swamp environments. The different types of diatoms found in the coal indicate that swamp environments were intermixed with lacustrine environments during the formation of the peat deposit or that the coal records environmental changes through time.

Mesodictyon, A New Fossil Genus of the Centric Diatom Family Thalassiosiraceae from the Miocene Chalk Hills Formation, Western Snake River Plain, Idaho

Three new centric diatom species assigned to a new genus are described from Miocene lacustrine deposits of Idaho. Species of the new genus, Mesodictyon, have the areola cribrum in the middle of the loculus, strutted processes and radiating, non-fasciculated striae. The strutted processes of M. magnum (diameter 60-150 μm) have long (2-3 μm) tubular extensions. The strutted processes of M. fovis (diameter 14-80 μm) are in distinct pits near the junction of the face and mantle. The valve face of M. undulatum (diameter 10-44 μm) is weakly tangentially undulate. Preliminary evidence indicates that Mesodictyon has a wide geographic distribution and may be a useful biostratigraphic marker.

Moving Under, Around, and Through the Miocene Reconstruction of Southern California

Modern southern California is fragmented by faults that juxtapose blocks with contrasting topographies and differing geologic histories. Many of the tectonic events that have shaped southern California were initiated during the Miocene, as subduction along the ancient trench margin off southern California was replaced by transform (strikeslip) faulting, such as that along the San Andreas fault.

Thalassiosira praeoestrupii- A New Diatom Species for Recognizing the Miocene/Pliocene Epoch Boundary in Coastal California

A new diatom species, Thalassiosira praeoestrupii Dumont, Baldauf and Barron, is described. The first occurrence of T. praeoestrupii in coastal California diatom-bearing outcrops occurs between the last occurrence of Rouxia californica at 6.0 Ma, and the first occurrence of Thalassiosira oestrupii at 5.1 Ma. The latter two species have customarily been used to identify the Miocene/Pliocene boundary. Paleomagnetic studies at Santa Cruz, California, demonstrate that the first occurrence of T. praeoestrupii coincides with the top of magnetic polarity Chron 5, which closely approximates the Miocene/Pliocene Epoch boundary.

Paleotemperature oscillations in the Middle and Late Miocene of the northeastern Pacific

The paleoclimatic and paleoceanographic history of the Middle and Late Miocene marginal eastern North Pacific as been studied in a north-to-south transect encompassing DSDP Site 173, the Newport Beach surface section, and DSDP Site 470, based on quantitative diatom and planktic foraminiferal analyses. Fourteen cold and 12 warm events that show close agreement with other microfossil studies as well as oxygen isotope records from low-latitude Pacific sites have been identified. Hiatuses are recognized at 7 to 6.5 Ma. 9.8 to 8.5 Ma, and 12 to 11 Ma at the three reference localities, and they correspond to widely recognized deep-sea hiatuses in the World Ocean.