Impact of body mass index on long-term clinical outcomes after second-generation drug eluting stent implantation: Insights from the international global RESOLUTE program

BACKGROUND An increased body mass index (BMI) is associated with a high risk of cardiovascular disease and reduction in life expectancy. However, several studies reported improved clinical outcomes in obese patients treated for cardiovascular diseases. The aim of the present study is to investigate the impact of BMI on long-term clinical outcomes after implantation of zotarolimus eluting stents. METHODS Individual patient data were pooled from the RESOLUTE Clinical Program comprising five trials worldwide. The study population was sorted according to BMI tertiles and clinical outcomes were evaluated at 2-year follow-up. RESULTS Data from a total of 5,127 patients receiving the R-ZES were included in the present study. BMI tertiles were as follow: I tertile (≤ 25.95 kg/m(2) -Low or normal weight) 1,727 patients; II tertile (>25.95 ≤ 29.74 kg/m(2) -overweight) 1,695 patients, and III tertile (>29.74 kg/m(2) -obese) 1,705 patients. At 2-years follow-up no difference was found for patients with high BMI (III tertile) compared with patients with normal or low BMI (I tertile) in terms of target lesion failure (I-III tertile, HR [95% CI] = 0.89 [0.69, 1.14], P = 0.341; major adverse cardiac events (I-III tertile, HR [95% CI] = 0.90 [0.72, 1.14], P = 0.389; cardiac death (I-III tertile, HR [95% CI] = 1.20 [0.73, 1.99], P = 0.476); myocardial infarction (I-III tertile, HR [95% CI] = 0.86 [0.55, 1.35], P = 0.509; clinically-driven target lesion revascularization (I-III tertile, HR [95% CI] = 0.75 [0.53, 1.08], P = 0.123; definite or probable stent thrombosis (I-III tertile, HR [95% CI] = 0.98 [0.49, 1.99], P = 0.964. CONCLUSIONS In the present study, the patients' body mass index was found to have no impact on long-term clinical outcomes after coronary artery interventions.

An den hohen constituirenden Reichstag in Wien! Die ungarische Nation, im heiligen Kampfe für ihre Freiheit und ihr gutes Recht ...

Welsch (Projektbearbeiter): Solidaritätsadresse des ungarischen an den österreichischen Reichstag in Wien: die Freiheit beider Länder ist bedroht. Option des Einmarschs ungarischer Truppen nach Österreich im Kampf gegen den gemeinsamen Feind, die "räuberischen Horden des Jellachich"

Kundmachung: Von Seite des Gemeinderathes der Stadt Wien wird hiemit bekannt gemacht, daß von demselben im Einverständnisse mit der medicinischen Fakultät ...

Welsch (Projektbearbeiter): Den Anordnungen der Ärzte Schuh, Dumreicher, Sigmund und Beyer ist in Bezug auf Pflege und Transport der Verwundeten unbedingte Folge zu leisten

Juli: In der Menagerie: Der grosse Wiener Fabeldichter Napoleon Ebersdorf ist damit beschäftigt ...

Welsch (Projektbearbeiter): Karikaturen auf den 'schwarz-gelben' Schriftsteller Joseph Sigmund Ebersberg sowie auf die militärische Werbung Freiwilliger zur Niederschlagung der Revolution in Böhmen

Ludwig Kossuth und Clemens Metternich

Welsch (Projektbearbeiter): Revolutionsroman des früheren Mitherausgebers des Wiener Blatts 'Der Radicale'. Dem französischen Schriftsteller Eugène Sue gewidmet

Impact of Diabetic Status on Outcomes After Revascularization With Drug-Eluting Stents in Relation to Coronary Artery Disease Complexity: Patient-Level Pooled Analysis of 6081 Patients.

BACKGROUND Diabetes mellitus and angiographic coronary artery disease complexity are intertwined and unfavorably affect prognosis after percutaneous coronary interventions, but their relative impact on long-term outcomes after percutaneous coronary intervention with drug-eluting stents remains controversial. This study determined drug-eluting stents outcomes in relation to diabetic status and coronary artery disease complexity as assessed by the Synergy Between PCI With Taxus and Cardiac Surgery (SYNTAX) score. METHODS AND RESULTS In a patient-level pooled analysis from 4 all-comers trials, 6081 patients were stratified according to diabetic status and according to the median SYNTAX score ≤11 or >11. The primary end point was major adverse cardiac events, a composite of cardiac death, myocardial infarction, and clinically indicated target lesion revascularization within 2 years. Diabetes mellitus was present in 1310 patients (22%), and new-generation drug-eluting stents were used in 4554 patients (75%). Major adverse cardiac events occurred in 173 diabetics (14.5%) and 436 nondiabetic patients (9.9%; P<0.001). In adjusted Cox regression analyses, SYNTAX score and diabetes mellitus were both associated with the primary end point (P<0.001 and P=0.028, respectively; P for interaction, 0.07). In multivariable analyses, diabetic versus nondiabetic patients had higher risks of major adverse cardiac events (hazard ratio, 1.25; 95% confidence interval, 1.03-1.53; P=0.026) and target lesion revascularization (hazard ratio, 1.54; 95% confidence interval, 1.18-2.01; P=0.002) but similar risks of cardiac death (hazard ratio, 1.41; 95% confidence interval, 0.96-2.07; P=0.08) and myocardial infarction (hazard ratio, 0.89; 95% confidence interval, 0.64-1.22; P=0.45), without significant interaction with SYNTAX score ≤11 or >11 for any of the end points. CONCLUSIONS In this population treated with predominantly new-generation drug-eluting stents, diabetic patients were at increased risk for repeat target-lesion revascularization consistently across the spectrum of disease complexity. The SYNTAX score was an independent predictor of 2-year outcomes but did not modify the respective effect of diabetes mellitus. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00297661, NCT00389220, NCT00617084, and NCT01443104.

Die Juden in Holland

Sigmund Seeligmann

Gibt es eine "arische" Rasse?

Sigmund Feist

"Gibt es eine arische Rasse"? : Eine Entgegnung

Sigmund Feist

[Rezension]

Arthur Freud

Judenlieder : (Gedichte)

Arthur Freud

Die jüdische Gemeinde von Triest

A. Freud

Jüdische Spuren im mittelalterlichen Zentralasien

Sigmund Feist

Josef als Ernährungsdiktator : eine wirtschaftliche Plauderei zum Pessachfest

Sigmund Fraenkel

Die neuerliche Agitation gegen das jüdisch-rituelle Schlachtverfahren

Sigmund Fränkel