Comprimidos de HPMC contendo nimesulida: preparação, caracterização e estudo dos mecanismos que regem a liberação do fármaco

The pharmaceutical innovations, such as the use of polymers to control drug release, create possibilities for a better action of the drug in the body, which causes a a more effective therapeutic effect and a safer treatment for the patient. In this work, were prepared and characterized matrix tablets of hydroxypropylmethylcellulose (HPMC) containing nimesulide as model drug to evaluate the performance as a controlled release system. HPMC, a cellulose ester, is a hydrophilic polymer that undergoes swelling, i.e., absorbs water and forms a gel layer controlling drug release. The characterization of powders was performed by analysis of particle size and morphology, density, compressibility index determination, flow properties and determination of swelling profile. The tablets were evaluated according to their physical parameters of quality and to the in vitro release of nimesulide, as well as the analysis of the mechanisms of drug release by appropriate mathematical models. The set of results showed that the HPMC/Nimesulide mixture exhibited satisfactory physical characteristics (size, shape, density and flow). The release profile demonstrated an effective control upon drug release in enteric environment and presented more correlation with Korsmeyer-Peppas’ and Weibull’s mathematical models, indicating that the release of nimesulide occurs through the relaxation of the polymer chains

Análise de patologias de estradas vicinais para proposta de intervenção mínima visando a sua perenização

The unpaved back roads, despite their simplicity, are of paramount importance to the municipalities that their economy basis are in agri-livestock and a large portion of their population lives in rural areas, as it is from these pathways that flow of production is performed and ensuring access of the rural population to urban centers is allowed. Aiming the importance of these rural roads, this work studies the case of pathologies found in local roads of São Luiz do Paraitinga, located in the Vale do Paraíba upstate São Paulo, due to lack of a periodic maintenance program the roads not withstood the heavy rains late in the year 2009 and early 2010, generating major impacts on society and the economy of the city. From surveys conducted in the field, it was analyzed the various pathologies found (pathology drainage, slope and platform) checking also the nature of their occurrence, therefore propose solutions for intervention in rural roads, to decrease the susceptibility of these roads during the rainy season

Efeitos da ocupação e uso da terra na bacia do córrego da Servidão, no cenário de 1995-2006

Urban sprawl developed without adequate urban planning and lack of knowledge about the physical characteristics of an environmental system, results in soil sealing and consequent change in the dynamics of hydrological watershed. Thus, this study aimed to analyze the behavior of the runoff basin Cóorego DA Servidão located in Rio Claro, referring to the year of 1995 compared to the scenario of 2006, compared the different features of urban use logged area. Therefore understanding the dynamics of the flow was possible through the use of software IPHS 1 that allowed through hydrologic models to evaluate the behavior of the surface area investigated, using Spring 4.3.3 software which enabled the classification of land use and software ArcGis 9.3 which was used for the quantification of stretches of water, separated from those that are channeled and those who did not suffer interference from the pipe

Avaliação da influência do substrato utilizado na qualidade e quantidade das parcelas de água escoada, percolada e armazenada em três estruturas experimentais de telhado verde extensino

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Análise da dinâmica do uso da terra e sua interferência em enchentes na área urbana do município de Americana (SP)

Due to an intense process of population growth and urban density in Americana (SP), mainly due to the development of the local textile industry after 1970, there was, concomitant to the occupation of the margin of rivers and streams, soil sealing that increased the level of superficial runoff, triggering frequent floods. Based on the analysis of these processes we investigate the conditions of one densely urbanized area of the county, the Córrego do Parque, in three time series, 1977, 1996 and 2008. Taking as the starting the characterization and spatial distribution of landscape physiography, we prepared thematic letters and synthetic maps digital scale 1:10,000 from photointerpretation of aeroframes. The thematic maps were produced by scanning with subsequent edition using the software Auto-Cad Map. Checking the data and of geographic coordinates with GPS (Global Positioning System). Regarding land use classes, we used the description of the Soil Conservation Service (1975) which allowed us to get the Curve Number parameter, which will be used in hydrologic modeling for verification of flooding (Tucci, 1989). For the process of hydrologic modeling, we used models based on Methodology Object Oriented Modeling Applied to Water Resource Systems, Viegas Filho (1999), using the computer program called IPHS1, which uses models of the Soil Conservation Service (SCS , 2004), for conversion of rainfall-runoff and the spread of excessive rain. The results indicate that increased waterproofing generated by the change in use and occupation over the past decades promoted the increased surface runoff and drainage system overload, increasing the intensity of floods

Análise geomorfológica e do uso da terra da bacia do Ribeirão Tijuco Preto (SP): subsídio ao planejamento ambiental

Este trabalho teve como objetivo principal analisar a dinâmica geomorfológica, bem como a apropriação humana do relevo, mediante a interpretação de forma integrada dos documentos cartográficos elaborados a partir de técnicas da cartografia morfométrica, geomorfológica e de uso da terra, de forma a subsidiar ações vinculadas ao planejamento ambiental da Bacia do Ribeirão Tijuco Preto (SP). Sob os auspícios da abordagem sistêmica, a partir de uma visão integrada e complexa dos sistemas geomorfológicos, propôs-se a quantificar os atributos das formas de relevo, representando-os cartográficamente com a elaboração das Cartas Morfométricas de Declividade ou Clinográfica (De Biase, 1970 e 1992), de Dissecação Horizontal (Spiridonov, 1981 e adaptações de Mauro et. al.,1991), de Dissecação Vertical (Spiridonov, 1981) e de Energia do Relevo (Mendes, 1993). Também, contemplou-se a cartografia geomorfológica de detalhe, com a elaboração da Carta Geomorfológica (Tricart, 1965), bem como o mapeamento do uso da terra, expresso na Carta de Uso da Terra (Ceron e Diniz, 1966). De forma geral, a análise dos Produtos Cartográficos elaborados, permitiu constatar que a Bacia do Ribeirão Tijuco Preto vem sofrendo o desencadeamento de processos erosivos variados. Tais processos estão associados a uma conjunção de condicionantes, que podem ser apontados pelas variadas condições morfométricas do terreno, o clima quente e úmido reinante, as diferentes litologias aflorantes, a tipologia dos solos, bem como, e, de maneira veemente, a intervenção humana. O condicionante antrópico está majoritariamente representado pela monocultura canavieira e pela urbanização, sendo agentes cruciais no desencadeamento dos processos erosivos existentes e na interferência direta na dinâmica do escoamento fluvial da Bacia do Ribeirão Tijuco Preto.

Contribuição das águas subterrâneas para a vazão do Ribeirão Boa Vista ou Córrego do Lajeado

This paper aimed to give a contribution to improve water resources management, consists of the analysis of interaction among groundwater and streamflow, by through the analysis of the relationship between basic and total streamflow, based on measured hidrological data from Ribeirão Boa Vista or Córrego Lajeado. watershed. Comparisons among groundwaterflow in this basin with another one in Rio Corumbataí basin were made based on the specific basic flow, in order to verify the possibility of the utilization of measured hydrological data in other basins with similar geological characteristics and soil use and occupation. Based upon the comparisons that were made, specific basic flow does not represent a good tool for extrapolation of measured data, indicating that this comparison shall be weighted by others characteristics as permeability and thickness of geological formations. Finally, it was possible to conclude that basic flow may be considered as an additional parameter for analysis of hydrological and hydrogeological characteristics of a basin and to provide subsidies to release legal licenses for water resources uses. related to surface water as well as for groundwater and may also be used as a tool for consolidation of integrated management of water resources, that is considered as a necessary and essential practice to avoid conflicts between users of water resources in a river basin.

Diagnóstico ambiental do Córrego Bandeirantes, município de Rio Claro, SP: parâmetros biológicos e metais-traço

This study was conducted to verify water quality and environmental impacts related to the occupation of the watershed of the Bandeirantes stream, located in Rio Claro, SP. The intention is to propose measures to enable the mitigation of negative impacts, and boosting the recovery and maintenance of the quality of water resources, preventing its complete degradation. Water analysis were performed at three different points, east, crossing the Ring Road (dirt road) and near the confluence with the Ribeirão Claro. The results indicated significant degradation of water, especially after the crossing, where it witnessed the accumulation of solid waste and easy access to the stream, both for animals as for people, due to limited riparian it. Another impact was observed the current construction of the Forum of Rio Claro in the right side of the stream studied, causing change in the landscape, change the flow properties and removal of existing vegetation at the site of work, defined as an environmentally protected area, as determined by existing law. Measures such as: restoration of riparian zones, effluent treatment, planned urban growth and environmental education of the population, would be essential to mitigate the environmental impacts of watershed Bandeirantes stream

Aplicação de técnicas alternativas para recuperação de foco eosivo em área rural situada no município de Álvares Machado – SP Presidente Prudente 2012

When handling soil conservation practices isn’t applied correctly, they cause problems at the level of structure, cohesion and fertility in soils and lack of water availability. In the case of this monograph, conducted in a rural property located at Álvares Machado City, identified that most areas are intended for use activities of beef cattle and dairy and subsistence agriculture, which historically addition to withdraw native flora, resulting in problems such as compaction and increase soil exposure to climatic agents, generating a serious frame of erosion problems. In the case of water from rainfall, the soil exposed, causes the “splash” effect and therefore when it becomes runoff carries the spalled particles mainly for low land areas. Without the vegetation, especially trees or shrubs species, the velocity of runoff increases, initiating the appearance of furrows, which consequently may become a kind of ravine erosion and gully, which makes invalid any area in your surroundings... (Complete abstract click electronic access below)

Subsídios para implantação de trincheiras de infiltração na área urbana de Rio Claro/SP

The purpose of this work is to study the theme “infiltration trenches” in some of its main aspects, such as sizing methods and parameters related to this, in order to subsidize the installation of these structures in the urban area of Rio Claro/SP. For purposes of sizing, the “rain-envelope method” was used for its simplicity and direct application from the local characterization data and the IDF (intensity-duration-frequency) curve data. The method bases on the determination of the tributary volume of input and output device. The curve of values accumulated over time of the volumes tributaries to the device, which is built on the flow rates obtained from the local IDF curve, is compared with the value curve of his effluent volumes determined from the flow characteristics obtained from the infiltration soil. The maximum difference between the curves is the volume sizing. Five locations were chosen in the urban area of Rio Claro for implementation of these devices, considering the soil type, hydraulic conductivity of each area and lot size according to the Master Plan of Rio Claro. This work also presented an estimated reduction of the runoff in urban lots by using infiltration trenches.

Avaliação da tenacidade em um aço microligado, grau API, para aplicação em linhas dutoviárias de petróleo e gás

In order to study the mechanical properties of micro alloyed steel API 5L X70, a material used to manufacture pipes for pipeline transportation lines for use in oil and gas, a study was made of toughness, tensile strength, impact strength, hardness and microstructure steel. To perform these various tests were made where they can acquire the characteristics of the material. Were performed at the Faculty of Engineering in Guaratinguetá in the Department of Materials and Technology and the tensile tests, Charpy impact test, metallography and hardness testing of material API 5L X70, all tests were done with the help of technical laboratories. With these data can be an analysis of the material about his tenacity, his toughness and fragility, its hardness, its yield strength and its maximum voltage. After being asked the analyzes discussed the results showed that the micro alloyed steel API 5L X70 steel is a very tenacious, it absorbs impact energy of 300 Joules though without a break for the full body of evidence showing its tenacity

Propriedades físico-químicas e mecânicas, potencial bioativo e caracterização da interface dentina-cimento de cimentos endodônticos experimentais à base de cimento Portland associados à radiopacificadores micro e nanoparticulados

Pós-graduação em Odontologia - FOAR

Privatizações no governo FHC e a evolução do transporte rodoviário no Brasil

Diante das transformações econômicas e políticas que marcaram os anos 1990 no Brasil, em especial o Governo de Fernando Henrique Cardoso, o presente estudo busca abordar os principais fatores que levaram à mudança do papel do Estado na economia, à evolução da malha rodoviária como um dos principais avanços do período, bem como às concessões de rodovias realizadas, as quais se tornaram essenciais ao desenvolvimento da infraestrutura brasileira e ao escoamento da produção nacional, inseridos no contexto das privatizações

Análise de fadiga em rodas automotivas utilizando método dos elementos finitos

The increasing search for better performance at the automotive industry, especially on the matter of fuel consumption, caused a progressive evolution of industrial technology. For the wheel this study is based on the try of reducing mass and decreasing the moment of inertia, characteristics that directly reflect on the performance parameter, as consumption and acceleration, so that it also is effective on the growth of the profit margin, since it reduces the costs of the locomotion. In this paper will be applied the Finite Element Analysis to explain the wheel behavior and identify ways to improve the performance. To the analyze it will be simulated a test condition established by ABNT NBR 6751:2009 foreseeing a possible collapse through general yielding and fatigue. The load here presented results from the equation presented on the norms and in the datas provided by the manufacturer

Estudo do aumento no diâmetro do corpo de um rebite a ser cravado em furos acima da tolerância de projeto

In this work are discussed the main types of rivets, their characteristics and applicability within the Aeronautical Industry branch. Here are highlighted the solid rivets, showing off its layout, forms and limits of installation, that are required by aviation regulators. The riveting is a popular and simple procedure of fixing and joining two or more parts, and like any other manufacturing process is subject to process deviations that in some situations are beyond the limits of tolerance. One of these deviations is when the hole diameter exceeds the one proposed in project and which is limited by the rule of edge distance. The overall objective here is to study a possible solution to this problem: the installation of a rivet that has his diameter previously increased by compression. Observe the hole filling after riveting, detect the presence of cracks, discover the yield curve of the fasteners and their the crushing limits for failure prediction are tools used to verify this proposal. They demonstrate, at the end of study, the inefficiency of this procedure, with results that go against the safe fixing of parts in a structure