Cosmos : a sketch of a physical description of the universe / By Alexander von Humboldt ; Translated from the German by E.C. Otté.

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Cosmos : a sketch of a physical description of the universe / By Alexander von Humboldt ; Translated from the German by E.C. Otté.

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Cosmos : a sketch of a physical description of the universe / By Alexander von Humboldt ; Translated from the German by E.C. Otté.

1

Cosmos : a sketch of a physical description of the universe / By Alexander von Humboldt ; Translated from the German by E.C. Otté.

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Phosphatidylinositol 3-Kinase-mediated Endocytosis of Renal Na+,K+-ATPase α Subunit in Response to Dopamine

Dopamine (DA) inhibition of Na+,K+-ATPase in proximal tubule cells is associated with increased endocytosis of its α and β subunits into early and late endosomes via a clathrin vesicle-dependent pathway. In this report we evaluated intracellular signals that could trigger this mechanism, specifically the role of phosphatidylinositol 3-kinase (PI 3-K), the activation of which initiates vesicular trafficking and targeting of proteins to specific cell compartments. DA stimulated PI 3-K activity in a time- and dose-dependent manner, and this effect was markedly blunted by wortmannin and LY 294002. Endocytosis of the Na+,K+-ATPase α subunit in response to DA was also inhibited in dose-dependent manner by wortmannin and LY 294002. Activation of PI 3-K generally occurs by association with tyrosine kinase receptors. However, in this study immunoprecipitation with a phosphotyrosine antibody did not reveal PI 3-K activity. DA-stimulated endocytosis of Na+,K+-ATPase α subunits required protein kinase C, and the ability of DA to stimulate PI 3-K was blocked by specific protein kinase C inhibitors. Activation of PI 3-K is mediated via the D1 receptor subtype and the sequential activation of phospholipase A2, arachidonic acid, and protein kinase C. The results indicate a key role for activation of PI 3-K in the endocytic sequence that leads to internalization of Na+,K+-ATPase α subunits in response to DA, and suggest a mechanism for the participation of protein kinase C in this process.

Os artigos federalistas : a contribuição de James Madison, Alexander Hamilton e John Jay para o surgimento do Federalismo no Brasil

Inclui bibliografia.

Revision of the Echini / by Alexander Agassiz.

no.7 (1872-1874) plates

The nature-printed British sea-weeds : a history, accompanied by figures and dissections of the Algae of the British Isles / By William Grosart Johnstone and Alexander Croall. Nature printed by Henry Bradbury.

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The Porpitidæ and Velellidæ / by Alexander Agassiz.

v.8:no.2 (1883)

Acculturation and material culture - George I. Quimby, Curator of Exhibits, Department of Anthropology, and Alexander Spoehr, Curator, Oceanic Ethnology.

v.36:no.6(1951)

Changing kinship systems: a study in the acculturation of the Creeks, Cherokee, and Choctaw / by Alexander Spoehr, Curator, Oceanic Ethnology. Formerly Curator, North American Ethnology and Archaeology.

v.33:no.4(1947)

The Florida Seminole camp / by Alexander Spoehr, Curator, North American Ethnology and Archaeology.

v.33:no.3(1944)