973 resultados para Clay, Laura--1849-1941
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Welsch (Projektbearbeiter): Bericht über den erfolgreichen Widerstand der badisch-pfälzischen Revolutionsarmee, der im Kampf gegen die aus Richtung Westen und Norden anrückenden Bundestruppen die Einnahme von Käfertal und Ladenburg gelingt. "... angesichts der numerischen Überlegenheit des Feindes [war jedoch] die Neckarlinie auf Dauer nicht zu halten ..." [1848/49: Rev. d. dt. Demokraten in Baden; Baden-Baden 1998, S. 372]
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Welsch (Projektbearbeiter): Bekanntgabe der 'Wahlcommissäre' sowie des Zuschnitts der Wahlbezirke im Landkommissariat Frankenthal anläßlich der Wahlen zum bayerischen Landtag 1849
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In Fraktur
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von Adolph Streckfuß
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Boberach: Ein katholischer Theologieprofessor schildert seine Erlebnisse als Feldkaplan der Akademischen Legion in Wien und als Abgeordneter in Kremsier bis zur Oktroyierung der Verfassung sowie während des Maiaufstands in Sachsen
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Boberach: Besonders ausführlich werden die militärischen Auseinandersetzungen ab Mitte September 1848 behandelt
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Most of the phyllosilicates detected at the surface of Mars today are probably remnants of ancient environments that sustained long-term bodies of liquid water at the surface or subsurface and were possibly favorable for the emergence of life. Consequently, phyllosilicates have become the main mineral target in the search for organics on Mars. But are phyllosilicates efficient at preserving organic molecules under current environmental conditions at the surface of Mars? We monitored the qualitative and quantitative evolutions of glycine, urea, and adenine in interaction with the Fe3+-smectite clay nontronite, one of the most abundant phyllosilicates present at the surface of Mars, under simulated martian surface ultraviolet light (190-400 nm), mean temperature (218 +/- 2 K), and pressure (6 +/- 1 mbar) in a laboratory simulation setup. We tested organic-rich samples that were representative of the evaporation of a small, warm pond of liquid water containing a high concentration of organics. For each molecule, we observed how the nontronite influences its quantum efficiency of photodecomposition and the nature of its solid evolution products. The results reveal a pronounced photoprotective effect of nontronite on the evolution of glycine and adenine; their efficiencies of photodecomposition were reduced by a factor of 5 when mixed at a concentration of 2.6x10(-2) mol of molecules per gram of nontronite. Moreover, when the amount of nontronite in the sample of glycine was increased by a factor of 2, the gain of photoprotection was multiplied by a factor of 5. This indicates that the photoprotection provided by the nontronite is not a purely mechanical shielding effect but is also due to stabilizing interactions. No new evolution product was firmly identified, but the results obtained with urea suggest a particular reactivity in the presence of nontronite, leading to an increase of its dissociation rate. Key Words: Martian surface-Organic chemistry-Photochemistry-Astrochemistry-Nontronite-Phyllosilicates. Astrobiology 15, 221-237.
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Chromosomal fusions are common in normal and cancer cells and can produce aberrant gene products that promote transformation. The mechanisms driving these fusions are poorly understood, but recurrent fusions are widespread. This suggests an underlying mechanism, and some authors have proposed a possible role for RNA in this process. The unicellular eukaryote Oxytricha trifallax displays an exorbitant capacity for natural genome editing, when it rewrites its germline genome to form a somatic epigenome. This developmental process provides a powerful model system to directly test the influence of small noncoding RNAs on chromosome fusion events during somatic differentiation. Here we show that small RNAs are capable of inducing chromosome fusions in four distinct cases (out of four tested), including one fusion of three chromosomes. We further show that these RNA-mediated chromosome fusions are heritable over multiple sexual generations and that transmission of the acquired fusion is associated with endogenous production of novel piRNA molecules that target the fused junction. We also demonstrate the capacity of a long noncoding RNA (lncRNA) to induce chromosome fusion of two distal germline loci. These results underscore the ability of short-lived, aberrant RNAs to act as drivers of chromosome fusion events that can be stably transmitted to future generations.
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Scan von Monochrom-Mikroform
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d.