Republik oder Monarchie? Beantwortet durch Thomas Paine's "gesunder Menschenverstand" und "Menschenrechte" : nach den Originalquellen bearbeitet

Boberach: Zur Begründung der republikanischen Staatsform sollen Auszüge aus Schriften Paines, u.a. "Über den Ursprung und Zweck des Staates im allgemeinen", über "Monarchie und Erbfolge", "Gesellschaft und Zivilisation", seine Dankadresse an das französische Volk von 1793 und "Aphorismen" u.a. über "Kirche und Staat", "Titel", "Sklaverei", "Papiergeld", Wahlrecht und eine kurze Biographie Paines beitragen

Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes

Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and associate with increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes mellitus and up to 46,061 without diabetes, followed by functional studies. Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (p=2.4*10(-10)). Gene-by-diabetes interactions were detected and confirmed for variants in HS6ST1 and near RAB38/CTSC. SNPs at these loci demonstrated a genetic effect on UACR in individuals with but not without diabetes. The change in average UACR per minor allele was 21% for HS6ST1 and 13% for RAB38/CTSC (p=6.3*10(-7) and 5.8*10(-7), respectively). Experiments using streptozotocin-treated diabetic Rab38 knockout and control rats showed higher urinary albumin concentrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 knockout vs. control rats. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared to controls. The loci identified here confirm known and highlight novel pathways influencing albuminuria.

Early versus delayed application of Thomas splints in patients with isolated femur shaft fractures: The benefits quantified

AIMS To investigate and quantify the clinical benefits of early versus delayed application of Thomas splints in patients with isolated femur shaft fractures. MATERIALS AND METHODS Level IV retrospective clinical and radiological analysis of patients presenting from January to December 2012 at a Level 1 Trauma Unit. All skeletally mature patients with isolated femur shaft fractures independently of their mechanism of injury were included. Exclusion criteria were: ipsilateral fracture of the lower limb, neck and supracondylar femur fractures, periprosthetic and incomplete fractures. Their clinical records were analysed for blood transfusion requirements, pulmonary complications, surgery time, duration of hospital stay and analgesic requirements. RESULTS A total of 106 patients met our inclusion criteria. There were 74 males and 32 females. Fifty seven (54%) patients were in the 'early splinted' group and 49 patients (46%) were in the 'delayed splinted' group (P>0.05). The need for blood transfusion was significantly reduced in the 'early splinted' group (P=0.04). There was a significantly higher rate of pulmonary complications in the 'delayed splinted' group (P=0.008). All other parameters were similar between the two groups. CONCLUSION The early application of Thomas splints for isolated femur fractures in non-polytraumatised patients has a clinically and statistically significant benefit of reducing the need for blood transfusions and the incidence of pulmonary complications.

Adrian Leverkühns 'Love's Labour Lost' als Interpretamtent für Thomas Manns 'Doktor Faustus'

Adrian Leverkühns erste Zwölfton-Komposition, die Oper ›Love's Labour Lost‹, soll hier diskursgeschichtlich auf die Bedeutung hin befragt werden, die sie für die Zeitdiagnose und Gesellschaftskritik des ›Doktor Faustus‹ hat. Zu diesem Zweck wird erst das zugrunde gelegte Drama in der Geschichte der Shakespeare-Rezeption situiert, dann aber auch die Konzeptions-, Entstehungs- und Aufführungsgeschichte seiner Vertonung im Gender-Diskurs der Weimarer Republik rekontextualisiert.

The Character of Christian-Muslim Encounter: Essays in Honour of David Thomas

The Character of Christian-Muslim Encounter is a Festschrift in honour of David Thomas, Professor of Christianity and Islam, and Nadir Dinshaw Professor of Inter Religious Relations, at the University of Birmingham, UK. The Editors have put together a collection of over 30 contributions from colleagues of Professor Thomas that commences with a biographical sketch and representative tribute provided by a former doctoral student, and comprises a series of wide-ranging academic papers arranged to broadly reflect three dimensions of David Thomas’ academic and professional work – studies in and of Islam; Christian-Muslim relations; the Church and interreligious engagement. These are set in the context of a focussed theme – the character of Christian-Muslim encounters – and cast within a broad chronological framework.

Ambroise Thomas [Illustration] : (Porträt-Büste)

Leopold Bernard Bernstamm

Eine Polemik des Thomas von Aquino gegen Maimonides

Hans Liebeschütz

Thomas de Pinedo : eine Biographie

Meir Kayserling

Romantische Politik bei Thomas Mann

Käthe Hamburger

Thomas Manns neuer Roman [Rezension]

Hans Bach

Jüdische Gestalten im Lebenswerk Thomas Manns : Zum 60. Geburtstag des Dichters am 6. Juni

Heinz Berggrün

Mit Thomas Mann über den Ozean [Rezension]

Hilde Cohn