A level set approach for the analysis of flow and compaction during resin infusion in composite materials

Fluid flow and fabric compaction during vacuum assisted resin infusion (VARI) of composite materials was simulated using a level set-based approach. Fluid infusion through the fiber preform was modeled using Darcy’s equations for the fluid flow through a porous media. The stress partition between the fluid and the fiber bed was included by means of Terzaghi’s effective stress theory. Tracking the fluid front during infusion was introduced by means of the level set method. The resulting partial differential equations for the fluid infusion and the evolution of flow front were discretized and solved approximately using the finite differences method with a uniform grid discretization of the spatial domain. The model results were validated against uniaxial VARI experiments through an [0]8 E-glass plain woven preform. The physical parameters of the model were also independently measured. The model results (in terms of the fabric thickness, pressure and fluid front evolution during filling) were in good agreement with the numerical simulations, showing the potential of the level set method to simulate resin infusion

Aquesta es una special deuoció del sanctissim nom de Jesus y del dulcissim nom de Maria ensemps ab los set goigs celestials de nostra senyora y altres deuocions [Texto impreso]

En port. y ms. 1515

Ypres rally network

Along of this document the reader could find a suitable network design and solution for the Rally Championship of Ypres meeting all the requirements set by the organization of the rally. These requirements have brought many problems in accordance with the network standards, because the area where the boxes are located is pretty large nevertheless technologies to solve those problems are detailed in the project. It has been included different designs in the project, each one of them based on distinct characteristic as they could be efficient, performance… , and the most important, since the organization of the rally is non-profit , the budget. Nevertheless we didn’t dismiss the use of long-lasting devices, as CISCO devices, despite their price. Furthermore a configuration of routing/switching devices has been explained for those who will be commanded to implement this solution. This solution is design to supply internet access as well as video streaming to all boxes for what teams can follow the championship in live time. The maximum connection of internet service provider (ISP) is 160Mbps, this bandwidth has to be distributed for the boxes dynamically. Finally to ensure the network works out it has to be monitored, this is reachable by using network analysis tools which in this project Wireshark has been chosen. RESUMEN. A lo largo de este documento, el lector encontrara un posible diseño y una posible solución para la red local del circuito de Rally celebrado en Ypres, cumpliendo con todos los requisitos y especificaciones establecidos por la organización. Estos requisitos han causado problemas de conformidad con los estándares de la red, debido a que la zona donde se encuentran los Boxes de los equipos es bastante larga, sin embargo las tecnologías para resolver esos problemas se detallan en este proyecto. Se han incluido diferentes diseños, cada uno de ellos centrado en aspectos diferentes así como la eficacia, el rendimiento, el presupuesto, etc... Esta solución está diseñada para suministrar acceso a Internet, así como la transmisión dinámica de video a todos los equipos para que puedan seguir la competición en tiempo real. Finalmente para controlar y asegurar que la red funciona, será monitorizada mediante herramientas de análisis de redes (Wireshark).

Bando cheneral, carta circular, ò manifest à tot el orbe sobre les grans festes que la ... ciutat de Valencia vá à fer à honor ... del beato Juan de Ribera, arzobispo y virey de ella en los añs mil sincsents xixanta y huit : [Texto impreso] y asó será en ... mil setsents noranta y set ... y Pio Papa Sexto, que el beatificá el ... añ mil setsents noranta y sis

Hay un ejemplar encuadernado con: Individual noticia de todos los altares, arcos pinturas, adornos y lo mas exquisito y notable que havia en la carrera de la procession, y de las iluminaciones en general ... : (XVIII/1705).

Relacio xistosa [Texto impreso] : ó xasco que va doná una guapa valenciana á set galans pretendents que volian conquistarla

Hay un ejemplar encuadernado con: Romans, y coloqui nou, pera divertir el humor y desterrar la melancolia, yà que no tenim dinès ... (NP849.91/3085).

Relacio xistosa [Texto impreso] : ó xasco que va doná una guapa valenciana á set galans pretendents que volian conquistarle

Hay un ejemplar encuadernado con: Bandos divertidísimos contra los borrachos y borrachas, y gente aficionada al vino(NP849.91/3087).

The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

The ALL-1 gene was discovered by virtue of its involvement in human acute leukemia. Its Drosophila homolog trithorax (trx) is a member of the trx-Polycomb gene family, which maintains correct spatial expression of the Antennapedia and bithorax complexes during embryogenesis. The C-terminal SET domain of ALL-1 and TRITHORAX (TRX) is a 150-aa motif, highly conserved during evolution. We performed yeast two hybrid screening of Drosophila cDNA library and detected interaction between a TRX polypeptide spanning SET and the SNR1 protein. SNR1 is a product of snr1, which is classified as a trx group gene. We found parallel interaction in yeast between the SET domain of ALL-1 and the human homolog of SNR1, INI1 (hSNF5). These results were confirmed by in vitro binding studies and by demonstrating coimmunoprecipitation of the proteins from cultured cells and/or transgenic flies. Epitope-tagged SNR1 was detected at discrete sites on larval salivary gland polytene chromosomes, and these sites colocalized with around one-half of TRX binding sites. Because SNR1 and INI1 are constituents of the SWI/SNF complex, which acts to remodel chromatin and consequently to activate transcription, the interactions we observed suggest a mechanism by which the SWI/SNF complex is recruited to ALL-1/trx targets through physical interactions between the C-terminal domains of ALL-1 and TRX and INI1/SNR1.

Examining the relationship between daily changes in support and smoking around a self-set quit date

This study was funded by the Swiss National Foundation (100014_124516). We would like to thank all students who helped with data collection.

Absence of a barrier to backwards rotation of the bacterial flagellar motor demonstrated with optical tweezers

A cell of the bacterium Escherichia coli was tethered covalently to a glass coverslip by a single flagellum, and its rotation was stopped by using optical tweezers. The tweezers acted directly on the cell body or indirectly, via a trapped polystyrene bead. The torque generated by the flagellar motor was determined by measuring the displacement of the laser beam on a quadrant photodiode. The coverslip was mounted on a computer-controlled piezo-electric stage that moved the tether point in a circle around the center of the trap so that the speed of rotation of the motor could be varied. The motor generated ≈4500 pN nm of torque at all angles, regardless of whether it was stalled, allowed to rotate very slowly forwards, or driven very slowly backwards. This argues against models of motor function in which rotation is tightly coupled to proton transit and back-transport of protons is severely limited.

O apelo ao legislador : apellentscheidung, na praxis da Corte Constitucional Federal Alemã / Gilmar Ferreira Mendes. --Tribunal Constitucional Alemão e o apelo ao legislador : "appelentscheidung" ; na praxis da Corte Constitucional Federal Alemã. Revista de Direito Público, vol 25 n 99 p 32 a 53 jul/set 1991."

Variação do título : Apelo ao legislador na Corte Constitucional Federal Alemã. Revista Trimestral de Direito Público, n 10 p 33 a 51 1995.

sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis

sqv (squashed vulva) genes comprise a set of eight independent loci in Caenorhabditis elegans required zygotically for the invagination of vulval epithelial cells and maternally for normal oocyte formation and embryogenesis. Sequencing of sqv-3, sqv-7, and sqv-8 suggested a role for the encoded proteins in glycolipid or glycoprotein biosynthesis. Using a combination of in vitro analysis of SQV enzymatic activities, sqv+-mediated rescue of vertebrate cell lines, and biochemical characterization of sqv mutants, we show that sqv-3, -7, and -8 all affect the biosynthesis of glycosaminoglycans and therefore compromise the function of one specific class of glycoconjugates, proteoglycans. These findings establish the importance of proteoglycans and their associated glycosaminoglycans in epithelial morphogenesis and patterning during C. elegans development.

Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays

We have systematically characterized gene expression patterns in 49 adult and embryonic mouse tissues by using cDNA microarrays with 18,816 mouse cDNAs. Cluster analysis defined sets of genes that were expressed ubiquitously or in similar groups of tissues such as digestive organs and muscle. Clustering of expression profiles was observed in embryonic brain, postnatal cerebellum, and adult olfactory bulb, reflecting similarities in neurogenesis and remodeling. Finally, clustering genes coding for known enzymes into 78 metabolic pathways revealed a surprising coordination of expression within each pathway among different tissues. On the other hand, a more detailed examination of glycolysis revealed tissue-specific differences in profiles of key regulatory enzymes. Thus, by surveying global gene expression by using microarrays with a large number of elements, we provide insights into the commonality and diversity of pathways responsible for the development and maintenance of the mammalian body plan.

A minimal gene set for cellular life derived by comparison of complete bacterial genomes.

The recently sequenced genome of the parasitic bacterium Mycoplasma genitalium contains only 468 identified protein-coding genes that have been dubbed a minimal gene complement [Fraser, C.M., Gocayne, J.D., White, O., Adams, M.D., Clayton, R.A., et al. (1995) Science 270, 397-403]. Although the M. genitalium gene complement is indeed the smallest among known cellular life forms, there is no evidence that it is the minimal self-sufficient gene set. To derive such a set, we compared the 468 predicted M. genitalium protein sequences with the 1703 protein sequences encoded by the other completely sequenced small bacterial genome, that of Haemophilus influenzae. M. genitalium and H. influenzae belong to two ancient bacterial lineages, i.e., Gram-positive and Gram-negative bacteria, respectively. Therefore, the genes that are conserved in these two bacteria are almost certainly essential for cellular function. It is this category of genes that is most likely to approximate the minimal gene set. We found that 240 M. genitalium genes have orthologs among the genes of H. influenzae. This collection of genes falls short of comprising the minimal set as some enzymes responsible for intermediate steps in essential pathways are missing. The apparent reason for this is the phenomenon that we call nonorthologous gene displacement when the same function is fulfilled by nonorthologous proteins in two organisms. We identified 22 nonorthologous displacements and supplemented the set of orthologs with the respective M. genitalium genes. After examining the resulting list of 262 genes for possible functional redundancy and for the presence of apparently parasite-specific genes, 6 genes were removed. We suggest that the remaining 256 genes are close to the minimal gene set that is necessary and sufficient to sustain the existence of a modern-type cell. Most of the proteins encoded by the genes from the minimal set have eukaryotic or archaeal homologs but seven key proteins of DNA replication do not. We speculate that the last common ancestor of the three primary kingdoms had an RNA genome. Possibilities are explored to further reduce the minimal set to model a primitive cell that might have existed at a very early stage of life evolution.