Esteroide e Triterpenos de espécies de Qualea: Bioatividade sobre Mycobacterium tuberculosis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Esteroide e Triterpenos de espécies de Qualea: bioatividade sobre Mycobacterium tuberculosis

The chloroform extract of bark of the tropical tree Qualea parviflora (Vochysiaceae) was fractionated by column chromatography on silica gel, yielding triterpenes (lupeol, lupenone, betulin, epi-betulinic acid and friedelin) and a steroid (β-sitosterol). β-sitosterol, lupenone and lupeol were also identified in Q. grandiflora and Q. multiflora, while friedelin was detected only in Q. Multiflora, by means of gas chromatography-mass spectrometry. The anti-Mycobacterium tuberculosis activity of the chloroform extract and isolated compounds was assayed by MABA and MIC values ranged from 250.0 to 31.2 µg/mL. This study is the first to investigate the chemistry and antitubercular activity of apolar compounds from Qualea species.

Mineral Loss and Morphological Changes in Dental Enamel Induced by a 16% Carbamide Peroxide Bleaching Gel

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Synthesis, Characterization, and Antifungal Activities of Amphiphilic Derivatives of Diethylaminoethyl Chitosan against Aspergillus flavus

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Bayesian age and growth analysis of the shortfin mako shark Isurus oxyrinchus in the Western South Atlantic Ocean using a flexible model

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Single precursor route to efficient cobalt sulphide counter electrodes for dye sensitized solar cells

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Use, development and improvements in the protocol of whole-sediment toxicity identification evaluation using benthic copepods

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

The slope of the VO2 slow component is associated with exercise intolerance during severe-intensity exercise

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise estrutural em relictos de cerrado no parque estadual do Guartelá, município de Tibagi, estado do Paraná, Brasil

This study was accomplished in existing Cerrado's relicts at State Park Guartelá, Tibagi, PR (24°39'10S and 50°15'25W), which represent one of the last extreme-meridional remanescents of this type of formation. Fifty plots with dimensions of 5x5m were allocated for phyto-sociological analysis, including in the sample individuals with height ≥ 1 m, divided into two samples to evaluate the following strata: a) upper-plants with DAS ≥ 3 cm, and b) intermediate - plants with DAS <3cm. Moreover, in each plot, there were established sub-plots with dimensions of 1x1m for sampling the lower stratum, comprised by individuals with height <1m and >10cm. The complete survey found 1340 individuals distributed in 28 families, 66 genera and 115 species. The diversity index was higher for the mean component (H'=3.30), followed by the superior component (H'=3.09) and the inferior (H'=2.91). The frequent occurrence of bushes is a remarkable characteristic of the physiognomy of the areas inside the park and 82 % of the populations studied are distributed in aggregated standard. Because it is a marginal region of occurrence of cerrado vegetation, now under the influence of a subtropical climate, more humid and cold, compared to the core area of this biome, it is noted that these areas are characterized by a decrease in stature, richness and diversity of its flora. Nevertheless, they preserve typical species of the Brazilian Savannah; but, due to their distribution in relicts and been, in part, devastated, some are included in the red list of endangered plants in Parana state, which evidences the importance of conservation and management of these areas.

Evaluation of dietary intake of calcium in adult subjects with idiopathic arterial hypertension

The calcium-intake relationship with other alimentary and anthropometric variables was investigates in a group of 60 adult (19-75 year-old) subjects, 50 females and 10 males, with essential arterial hypertension (DAP > 90 mmHg). The calcium intake was assessed by three different protocols: 24-hour food intake recall, food-frequency questionnaire and 3 day self-food intake register, repeated along with anthropometric measurements on three different occasions (2-15 month-intervals). The calcium intake assessed by the three methods, as well as the anthropometric data, were statistically similar on all three occasions. The mean data were then compared with those form the control, composed of 75 healthy subjects matched with the hypertensive group by age and sex. The patients ingested less calcium (mean +/- SD) than the controls on the daily (517 +/- 271 x 740 +/- 353 mg/d) and body-weight (8.1 +/- 5.0 x 11.4 +/- 5.9 mg/kg/d) basis. Among the males the calcium intake was the only difference found between groups and could be attributed to the lower intake of calcium-rich foods. The hypertensive females showed also higher lean-body mass (Body-mass index and arm muscle circumference). Thus the calcium intake discriminated both groups being associated with changes in other nutritional parameters only in females.

A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Vaccination of sheep and cattle against haemonchosis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Reconstruction of maxillary ridge atrophy caused by sequela of dentoalveolar trauma with autogenous bone graft harvested from mentum

Dentoalveolar traumatisms, particularly those that affect the anterior teeth, interfere adversely in the patient s life.Among them, tooth avulsion is pointed out because it is characterized as a complex injury that affects multiple tissues, andbecause there is no effective treatment available for its resolution with a stable long-term outcome.Aim/Hypothesis: The aim of the present study was to relate a clinical case of complete reconstruction of atrophy of the alveolarbone corresponding to tooth 11, lost by tooth resorption 10 years after the tooth reimplantation procedure.Material and methods: Reconstruction was performed with autogenous bone harvested from the mentum donor site. Surgicalaccess began in the receptor area with a Newman mucoperiosteal incision using a scalpel blade 15 mounted in a scalpel handlefor detachment and exposure of the receptor site. Extensive bone resorption was observed in the vestibular-palatine direction,proved by the thinness of the receptor bed. Decorticalization of the vestibular bone plate was performed. After preparing thereceptor bed, and incision was made in the mucosa in the depth of the anterior vestibular fornix, then a perpendicular muscleperiostealincision to detach and exposure the donor area. The bone graft necessary for reconstruction of the donor area wasdelimited, followed by monocortical osteotomy and the monocortical graft was removed. The next stage was to perform shapingfor passive graft accommodation and fixation by means of two bicortical screws. After fixation of the graft the sharp angles wererounded off in order to avoid possible exposure and/or fenestrations of the reconstructed area, then the receptor and donor areawere sutured. After the 6-month period to allow incorporation of the autogenous graft, an osseointegrated dental implant wasinserted. At the end of the 6-month period of waiting for osseointegration to occur, the process of fabricating the screw-retainedmetal ceramic

Correlação da circunferência escrotal, citologia testicular e parâmetros do sêmen do epidídimo de touros

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)