997 resultados para 1-(O-hexose)-3,25-hexacosanediol
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[Traditions. Asie. Inde. Province de Delhi]
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[Traditions. Asie. Inde. Etat du Karnataka. Kanara]
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[Traditions. Asie. Inde. Province du Bihar. Darbhanga]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. Etat du Karnara]
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BACKGROUND: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. METHODOLOGY/PRINCIPAL FINDINGS: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D(3) (25[OH]D(3)) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061-2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D(3)<20 ng/mL) during all seasons, but 25(OH)D(3) serum levels were not associated with treatment outcome. CONCLUSIONS/SIGNIFICANCE: Our study suggests a role of bioactive vitamin D (1,25[OH](2)D(3), calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D(3) is not a suitable predictor of treatment outcome.
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[Traditions. Asie. Inde. État du Karnataka. Dharwar]
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[Traditions. Asie. Inde. Chhattisgarh. Surguja]
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[Traditions. Asie. Inde. État du Maharashtra. Dhule]
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[Traditions. Asie. Inde. Province de Bombay. Région du Haut-Sindh]
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[Traditions. Asie. Inde. Madhya Pradesh]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]]
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[Traditions. Asie. Inde. Chotā Nāgpur]
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[Traditions. Asie. Inde. Chotā Nāgpur]
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[Traditions. Asie. Inde. Chotā Nāgpur]