913 resultados para solute-drag
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A Amazônia vem sofrendo severas mudanças provocadas por atividades antrópicas, dentre as quais se destaca a transformação de áreas de floresta em áreas de uso agropecuário, resultando na intensificação dos processos erosivos. A erosão, com destaque ao arraste de partículas pelo escoamento superficial, causa redução da fertilidade do solo, prejudicando a produtividade agrícola, além de impactar a qualidade e quantidade dos recursos hídricos superficiais, fato agravado pelo forte regime pluviométrico e solos naturalmente pobres da região. Nesse contexto, o conhecimento dos processos erosivos, através da utilização de modelos matemáticos para predição da perda de solo, auxilia na determinação de práticas de manejo para o uso sustentável dos recursos naturais. A presente pesquisa buscou avaliar a aplicabilidade do modelo empírico RUSLE (Revised Universal Soil Loss Equation) na região, o qual considera a interação entre a energia da chuva, as características de solo e relevo, assim como os usos e manejos praticados. A pesquisa aplicou a RUSLE no trecho superior da bacia do igarapé da Prata, com uma área aproximada de 37 km², que fica localizada no município de Capitão Poço/PA, aproximadamente 160 km da capital Belém, na Meso Região Nordeste Paraense. A metodologia empregada constou da construção de uma base de dados georreferenciada, formada a partir de fontes públicas, que passaram por adequações para inserção no ambiente SIG, que quando combinados permitiram a geração de um mapa de perda de solo da área de estudo. A pequena bacia do igarapé da Prata apresentou valores da perda de solo que variaram entre 0,004 e 72,48 t/ha.ano, com uma média de 5,12 e desvio padrão de 6,97, onde aproximadamente 12% de sua área total apresentam riscos ambientais devido aos processos erosivos. E o percentual restante, para não sofrer riscos, depende de boas práticas conservacionistas.
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Experiments were conducted to investigate the influence of thermal parameters on the columnar to equiaxed transition during the horizontal unsteady-state directional solidification of Al-Si alloys. The parameters analyzed include the heat transfer coefficients, growth rates, cooling rates, temperature gradients and composition. A combined theoretical and experimental approach is developed to determine the solidification thermal variables considered. The increasing solute content in Al-Si alloys was not found to affect significantly the experimental position of the CET which occurred for cooling rates in the range between 0.35 and 0.64 K/s for any of three alloy compositions examined. A comparative analysis between the results of this work and those from the literature proposed to analyze the CET during upward vertical solidification of Al-Si alloys is reported and the results have shown that the end of the columnar region during horizontal directional solidification is abbreviated as a result of about six times higher thermal gradient than that verified during upward unidirectional solidification of alloys investigated.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Pós-graduação em Engenharia Mecânica - FEG
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Engenharia Mecânica - FEG
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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A second-order closure is developed for predicting turbulent flows of viscoelastic fluids described by a modified generalised Newtonian fluid model incorporating a nonlinear viscosity that depends on a strain-hardening Trouton ratio as a means to handle some of the effects of viscoelasticity upon turbulent flows. Its performance is assessed by comparing its predictions for fully developed turbulent pipe flow with experimental data for four different dilute polymeric solutions and also with two sets of direct numerical simulation data for fluids theoretically described by the finitely extensible nonlinear elastic - Peterlin model. The model is based on a Newtonian Reynolds stress closure to predict Newtonian fluid flows, which incorporates low Reynolds number damping functions to properly deal with wall effects and to provide the capability to handle fluid viscoelasticity more effectively. This new turbulence model was able to capture well the drag reduction of various viscoelastic fluids over a wide range of Reynolds numbers and performed better than previously developed models for the same type of constitutive equation, even if the streamwise and wall-normal turbulence intensities were underpredicted.
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Glycosomes are peroxisome-related organelles found in all kinetoplastid protists, including the human pathogenic species of the family Trypanosomatidae: Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. Glycosomes are unique in containing the majority of the glycolytic/gluconeogenic enzymes, but they also possess enzymes of several other important catabolic and anabolic pathways. The different metabolic processes are connected by shared co-factors and some metabolic intermediates, and their relative importance differs between the parasites or their distinct life-cycle stages, dependent on the environmental conditions encountered. By genetic or chemical means, a variety of glycosomal enzymes participating in different processes have been validated as drug targets. For several of these enzymes, as well as others that are likely crucial for proliferation, viability or virulence of the parasites, inhibitors have been obtained by different approaches such as compound libraries screening or design and synthesis. The efficacy and selectivity of some initially obtained inhibitors of parasite enzymes were further optimized by structure-activity relationship analysis, using available protein crystal structures. Several of the inhibitors cause growth inhibition of the clinically relevant stages of one or more parasitic trypanosomatid species and in some cases exert therapeutic effects in infected animals. The integrity of glycosomes and proper compartmentalization of at least several matrix enzymes is also crucial for the viability of the parasites. Therefore, proteins involved in the assembly of the organelles and transmembrane passage of substrates and products of glycosomal metabolism offer also promise as drug targets. Natural products with trypanocidal activity by affecting glycosomal integrity have been reported.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)