Audubon 2004 Annual County Profile, 2004

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A TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcoma.

We have recently demonstrated that human pediatric mesenchymal stem cells can be reprogrammed toward a Ewing sarcoma family tumor (ESFT) cancer stem cell (CSC) phenotype by mechanisms that implicate microRNAs (miRNAs). Here, we show that the miRNA profile of ESFT CSCs is shared by embryonic stem cells and CSCs from divergent tumor types. We also provide evidence that the miRNA profile of ESFT CSCs is the result of reversible disruption of TARBP2-dependent miRNA maturation. Restoration of TARBP2 activity and systemic delivery of synthetic forms of either of two of its targets, miRNA-143 or miRNA-145, inhibited ESFT CSC clonogenicity and tumor growth in vivo. Our observations suggest that CSC self-renewal and tumor maintenance may depend on deregulation of TARBP2-dependent miRNA expression.

Benton 2004 Annual County Profile, 2004

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Black Hawk 2004 Annual County Profile, 2004

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Boone 2004 Annual County Profile, 2004

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Bremer 2004 Annual County Profile, 2004

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Calhoun 2004 Annual County Profile, 2004

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Buchanan 2004 Annual County Profile, 2004

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Buena Vista 2004 Annual County Profile, 2004

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Cherokee 2004 Annual County Profile, 2004

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Butler 2004 Annual County Profile, 2004

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Carroll 2004 Annual County Profile, 2004

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Cass 2004 Annual County Profile, 2004

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Cedar 2004 Annual County Profile, 2004

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Cerro Gordo 2004 Annual County Profile, 2004

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