Exploring oxidative modifications of tyrosine:an update on mechanisms of formation, advances in analysis and biological consequences

Protein oxidation is increasingly recognised as an important modulator of biochemical pathways controlling both physiological and pathological processes. While much attention has focused on cysteine modifications in reversible redox signalling, there is increasing evidence that other protein residues are oxidised in vivo with impact on cellular homeostasis and redox signalling pathways. A notable example is tyrosine, which can undergo a number of oxidative post-translational modifications to form 3-hydroxy-tyrosine, tyrosine crosslinks, 3-nitrotyrosine and halogenated tyrosine, with different effects on cellular functions. Tyrosine oxidation has been studied extensively in vitro, and this has generated detailed information about the molecular mechanisms that may occur in vivo. An important aspect of studying tyrosine oxidation both in vitro and in biological systems is the ability to monitor the formation of oxidised derivatives, which depends on a variety of analytical techniques. While antibody-dependent techniques such as ELISAs are commonly used, these have limitations, and more specific assays based on spectroscopic or spectrometric techniques are required to provide information on the exact residues modified and the nature of the modification. These approaches have helped understanding of the consequences of tyrosine oxidation in biological systems, especially its effects on cell signalling and cell dysfunction, linking to roles in disease. There is mounting evidence that tyrosine oxidation processes are important in vivo and can contribute to cellular pathology.

The uncertainty enabled model web (UncertWeb)

UncertWeb is a European research project running from 2010-2013 that will realize the uncertainty enabled model web. The assumption is that data services, in order to be useful, need to provide information about the accuracy or uncertainty of the data in a machine-readable form. Models taking these data as imput should understand this and propagate errors through model computations, and quantify and communicate errors or uncertainties generated by the model approximations. The project will develop technology to realize this and provide demonstration case studies.

A hazai vállalatok nyitottsága az elektronikus beszerzésre (E-procurement Responsivess of the Hungarian Companies')

A Versenyképesség Kutató Központ 2004-ben a "Versenyben a világgal 1995-97" kutatási program és az 1999-es vállalati versenyképességi kérdőíves felmérés hagyományait folytatva, valamint azok tapasztalataira építve, egy hároméves kutatási programot kezdett el "Versenyben a világgal 2004-2006 – Gazdasági versenyképességünk vállalati nézőpontból" címmel. A kérdőíves felmérés nyomán létrejött adatbázist hasonló témában elemezték a szerzők 2005-ben. A korábbi eredményeken okulva, valamint a kérdőívelemzés kiterjesztésével azt kívánták felmérni, hogy az elektronikus beszerzés iránti nyitottság növekedett-e hazánkban, illetve milyen egyéb összefüggések fedezhetők fel a beszerzési szervezet, a beszerzés vállalati kapcsolatai, valamint az elektronikus beszerzés értelmezésében az egyes válaszadóknál. A kutatás továbbra is eltér a hagyományos megoldásoktól, azaz nem kívánja vizsgálni a hazai vállalati honlapok elterjedtségét, azonban a korábbiaktól eltérően több információtechnológiával kapcsolatos információt kér a válaszadóktól. A cél a belső vállalati folyamatok, a vevő-szállító kapcsolatok, az informatikai háttér elektronikus beszerzéssel való kapcsolatának felismerése. Meg szeretnék tudni, hogy az elektronikus beszerzés milyen hatékonyságnövelési lehetőséget hordoz és a hazai információs társadalmi fejlettség figyelembevételével mennyire nyitottak erre a beszerzők és a pályázók. Az elektronikus beszerzés és versenyképesség kapcsolata különösen a 2000-es évek eleje óta foglalkoztatja a kutatókat. Vita az elektronikus beszerzés beszerzési költségre gyakorolt hatásával, valamint a kormányzati politika hatásával kapcsolatban alakult ki, melyet a közbeszerzés, mint speciálisan szabályozott beszerzési tevékenység és az e-beszerzés kapcsolatára fejt ki. A vállalatok versenyképességének és az elektronikus beszerzés folyamatosan. / === / The Competitiveness Research Center based on the experience of the „ In Global Competition 1995-1997” research program and continuing the company competitiveness survey (1999) has begun a three-year research program with the following title: „In Global Competition 2004- 2006” Our economic competitiveness from company point of view”. The authors had analyzed a database generated on the basis of a questionnaire survey with a similar theme in 2005. Drawing the lessons from earlier researches and expanding the questionnaire, they now seek to find out how far receptiveness to electronic procurement has increased in Hungary and what other relations can be observed in responses concerning the interpretation of procurement organizations, the corporate aspects of procurement and electronic procurement. The new research project continues to differ from traditional solutions insofar as it does not intend to examine the penetration of corporate web pages, but, in contrast to earlier practice, it does want responders to provide information on their IT technology. The objectives are thus to understand how electronic procurement relates to corporate processes, purchaser-supplier relations and IT base, and to see what opportunities of increasing efficiency there are in electronic procurement and how far procurers and bidders are open to this at the current level of information society development in Hungary. Researchers have focused on the relation between electronic procurement and competitiveness since the early 2000s. What is debated is how electronic procurement influences procurement costs, and how government policies influence the relation between public procurement as a specially regulated procurement activity and electronic procurement. The relation between corporate competitiveness and the continually increasing means of electronic procurement is beyond doubt, evidenced by their research findings as well.

A hazai vállalatok elektronikus beszerzés iránti nyitottsága = E-procurement Responsiveness of the Hungarian Companies’

A Versenyképesség Kutató Központ 2004-ben a „Versenyben a világgal 1995-97.” kutatási program és az 1999-es vállalati versenyképességi kérdőíves felmérés hagyományait folytatva, valamint azok tapasztalataira építve egy hároméves kutatási programot kezdett el „Versenyben a világgal 2004-2006 − Gazdasági versenyképességünk vállalati nézőpontból” címmel. A kérdőíves felmérés nyomán létrejött adatbázist elemeztük hasonló témában 2005-ben. A korábbi eredményeken okulva, a kérdőív-elemzés kiterjesztésével azt kívántuk felmérni, hogy az elektronikus beszerzés iránti nyitottság növekedett-e hazánkban, illetve milyen egyéb összefüggések fedezhetők fel a beszerzési szervezet, a beszerzés vállalati kapcsolatai, valamint az elektronikus beszerzés értelmezésében az egyes válaszadóknál. A kutatás továbbra is eltér a hagyományos megoldásoktól, azaz nem kívánja vizsgálni a hazai vállalati honlapok elterjedtségét, azonban a korábbiaktól eltérően több információ-technológiával kapcsolatos információt kíván a válaszadóktól. A cél, tehát belső vállalati folyamatok, vevő-szállító kapcsolatok, az informatikai háttér elektronikus beszerzéssel való kapcsolatának feltárása és következtetéseink levonása volt annak érdekében, hogy megtudjuk milyen hatékonyságnövelési lehetőséget hordoz az elektronikus beszerzés és a hazai információs társadalmi fejlettség figyelembe vételével mennyire nyitottak erre a beszerzők és a pályázók egyaránt. Az elektronikus beszerzés és versenyképesség kapcsolata különösen a 2000-es éves eleje óta foglalkoztatja a kutatókat. Vita az elektronikus beszerzés beszerzési költségre gyakorolt hatásában, valamint a kormányzati politika által gyakorolt hatás jellegében van, melyet a közbeszerzés mint speciálisan szabályozott beszerzési tevékenység és az e-beszerzés kapcsolatára fejt ki. A vállalatok versenyképességének és az elektronikus beszerzés folyamatosan bővülő és fejlődő eszközrendszerének kapcsolata azonban nem kérdéses, ezt kutatási eredményeink is megerősítik. _________ The Competitiveness Research Center based on the experience of the „ In Global Competition 1995-1997” research programme and continuing the company competitiveness survey (1999) has begun a three-year research programme with the following title: „In Global Competition 2004-2006” Our economic competitiveness, company point of view”. We had analyzed a database generated on the basis of a questionnaire survey with a similar theme in 2005. Drawing the lessons from earlier researches and expanding the questionnaire examination, we now seek to find out how far receptiveness to electronic procurement has increased in Hungary and what other relations can be observed in responses concerning the interpretation of procurement organizations, the corporate aspects of procurement and electronic procurement. The new research project continues to differ from traditional solutions insofar as it does not intend to examine the currency of corporate web pages, but, in contrast to earlier practice, it does want responders to provide information on IT technology. The objectives are thus to understand how electronic procurement relates to corporate processes, purchaser-supplier relations and IT base, and to see what opportunities of increasing efficiency there are in electronic procurement and how far procurers and bidders are open to this at the level of information society development in Hungary. Researchers have focused on the relation between electronic procurement and competitiveness since the early 2000s. What is debated is how electronic procurement influences procurement costs, and how government policies influence the relation between public procurement as a specially regulated procurement activity and electronic procurement. The relation between corporate competitiveness and the continually increasing means of electronic procurement is beyond doubt, evidenced by our research findings.

Understanding Annual Reports of Hospitality Firms

In her discussion - Understanding Annual Reports of Hospitality Firms - by Elisa S. Moncarz, Associate Professor, School of Hospitality Management, Florida International University, Associate Professor Moncarz initially offers: “Management bears full responsibility for the reporting function of annual reports prepared by publicly-held companies designed to provide interested parties with information that is useful in making business and economic decisions. In Part I the author reviews the content of annual reports of firms in the hospitality industry, while looking at recent developments affecting annual reports. Part 11, in a subsequent issue, will comprise an in-depth examination of the annual report of an actual firm in the hospitality industry, focusing on suggested guidelines and recommendations for how to use annual reports as an aid to the decision-making process in the hospitality industry.” This article is to be considered a primer on reading and understanding annual reports, as well as a glimpse into the dynamics that affect them. In defining what an annual report is, Associate Professor Moncarz informs you with citation, “Annual reports are required by the Securities Exchange Commission (SEC) ¹ for all companies with securities sold to the general public. These reports, which must be issued within 90 days after the close of the calendar (or fiscal) year, comprise a primary source of information about these companies,” she further reports. “Indeed, the official version of the company's history is summed up yearly in its annual report by providing full information of the company's operations over the period as well as what the company is gearing up to accomplish in the next year,” Professor Moncarz closes the definition. Why should thus happen over and above SEC requirements? The financial component is an important one; the author offers her informed view: “The major objective of financial statement reporting is to provide information that is useful to present and potential investors, creditors, and other financial statement users in making rational investment, credit, and similar decisions. Thus, financial statements represent the primary (and most reliable) source of knowledge about a particular firm in the hospitality industry.” The above two paragraphs crystallize the requirement and the objective of annual reports. “A typical annual report of a hospitality firm contains a number of standard features which may be broken down into the following three sections…” General, financial data, and supplementary data are variously bounded and circumscribed for you. As a marketing device and feel-good initiative, the annual report is a useful tool for a hospitality corporation that is in-the-black, and focused on the future, says the author. She cites the Marriott Corporation’s 1985 annual report as an example. Of course, an annual report can also be a harbinger of bad news for shareholders as well. Notes/footnotes and disclosure are key elements to the credibility of any annual report; Professor Moncarz discusses these concepts at length. “Given the likelihood that the hospitality industry will continue to face an uncertain economic environment for some time, financial statement users should become more demanding in their need for information that will help assure the firm's survival and evaluate its ability to generate earnings, increase the firm's investment value, and provide for its future growth,” Professor Moncarz says. “Accordingly, understanding annual reports in the hospitality industry should become even more critical.”

Extended program notes for a recital of selected vocal literature

The purpose of these extended program notes is to provide information that will assist the listening audience in comprehending the historical and biographical significance of the each vocal selection. A brief analysis of each selection, a historical interpretation of the work, a translation of the texts and a CD of the recital are included. The contents of the recital comprise of several selections from the soprano repertoire: The Georg Phillip Telemann cantata Lauter Wonne, lauter Freude; the Wolfgang Amadeus Mozart Laudate Dominum from the Vesperae solemnes de confessore; the Joaquin Nin y Castellano Diez Villancicos de Noel; Gabriel Faurd's art songs Dans le ruines d'une abbay, Les Berceaux, and Au bord e l'eau; Sergei Rachmaninov's three songs Oni otvechali, Zdes Khorosho, and Vocalise; and Libby Larsen's Cowboy Songs.

Análise do uso do Portal de Periódicos da CAPES na perspectiva de mestres e doutores formados pelo Programa de Pós-graduação em Administração da UFRN

The Brazilian CAPES Journal Portal aims to provide Information in Science and Technology (IST) for academic users. Thus, it is considered a relevant instrument for post-graduation dynamics and the country´s Science and Technology (S&T) development. Despite its importance, there are still few studies that focus on the policy analysis and efficiency of these resources. This research aims to fill in this gap once it proposes an analysis of the use of the CAPES Journal Portal done on behalf of the master´s and doctoral alumni of the Post Graduate Program in Management (PPGA) at the Federal University of Rio Grande do Norte (UFRN). The operationalization of the research´s main objective was possible through the specific objectives: characterize graduate profile as CAPES Journal Portal users b) identify motivation for the use of CAPES Journal Portal c) detect graduate satisfaction degree in information seeking done at CAPES Journal Portal d) verify graduate satisfaction regarding the use of the CAPES Journal Portal e) verify the use of the information that is obtained by graduates in the development of their academic activities. The research is of descriptive nature employing a mixed methodological strategy in which quantitative approach predominates. Data collection was done through a web survey questionnaire. Quantitative data analysis was made possible through the use of a statistical method. As for qualitative analysis, there was use of the Brenda Dervin´s sense-making approach as well as content analysis in open ended questions. The research samples were composed by 90 graduate students who had defended their dissertation/thesis in the PPGA program at UFRN in the time span of 2010-2013. This represented by 88% of this population. As for user profile, the analysis has made evident that there are no quantitative differences related to gender. There is predominance of male graduates that were aged 26 to 30 years old. As for female graduates, the great majority were 31 o 35 years old. Most graduates had Master´s degree scholarship in order to support their study. It was also seen that the great majority claim to use the Portal during their post graduation studies. The main reasons responsible for non use was: preference for the use of other data bases and lack of knowledge regarding the Portal. It was observed that the most used information resources were theses and dissertations. Data also indicate preference for complete text. Those who have used the Portal also claimed to have used other electronic information fonts in order to fulfill their information needs. The information fonts that were researched outside in the Portal were monographs, dissertations and thesis. Scielo was the most used information font. Results reveal that access and use of the Portal has been done in a regular manner during post graduation studies. But on the other hand, graduates also make use of other electronic information fonts in order to meet their information needs. The study also confirmed the important mission performed by the Portal regarding Brazilian scientific communication production. This was seen even though users have reported the need for improvement in some aspects such as: periodic training in order to promote, encourage and teach more effective use of the portal; investment aiming the expansion of Social Sciences Collection in the Portal as well as the need to implement continuous evaluation process related to user satisfaction in regarding the services provided.

Luís da Câmara Cascudo prefaciador

Presenting a reading of prefaces written by Luís da Câmara Cascudo, related to literary and non-literary books from the early 20TH century (1921-1984), is the goal of this thesis. Considering the word in its meaning: "Latin praefatio, the action of speaking in the commencement. Synonym for 'prologue ', in the sense of text that precedes or introduces a work" (MOISÉS, 1999, p.416). In this research, a preface is understood as the text written and published with the intent to provide information to facilitate reading and/or understanding of the work to which it refers, regardless it is set at initial pages, when it is named as „prolog‟, „letter to the reader‟, „proem‟, „prelude‟, „preamble, forewords, summary, etc., or when only appears in the last pages of the book and turns to be named as „afterword‟. It is a qualitative research, with a bibliographic and interpretive feature, considering that part of the analysis of texts employs the inductive method, focuses on the depth of understanding that the researcher has on the researched object. For the study of this genre we recourse to Sales (2003), Teles (1986; 1989; 2010), Clemente (1986) and Candido (2005); as for the notion of tradition, we resort to Eliot (1997) and Candido (1997; 1980). The set of prefaces is a wide material for research that will allow scholars of Brazilian culture to continue work started by Luís da Câmara Cascudo, still in 1921, when he started his career as a prefacer.

Luís da Câmara Cascudo prefaciador

Presenting a reading of prefaces written by Luís da Câmara Cascudo, related to literary and non-literary books from the early 20TH century (1921-1984), is the goal of this thesis. Considering the word in its meaning: "Latin praefatio, the action of speaking in the commencement. Synonym for 'prologue ', in the sense of text that precedes or introduces a work" (MOISÉS, 1999, p.416). In this research, a preface is understood as the text written and published with the intent to provide information to facilitate reading and/or understanding of the work to which it refers, regardless it is set at initial pages, when it is named as „prolog‟, „letter to the reader‟, „proem‟, „prelude‟, „preamble, forewords, summary, etc., or when only appears in the last pages of the book and turns to be named as „afterword‟. It is a qualitative research, with a bibliographic and interpretive feature, considering that part of the analysis of texts employs the inductive method, focuses on the depth of understanding that the researcher has on the researched object. For the study of this genre we recourse to Sales (2003), Teles (1986; 1989; 2010), Clemente (1986) and Candido (2005); as for the notion of tradition, we resort to Eliot (1997) and Candido (1997; 1980). The set of prefaces is a wide material for research that will allow scholars of Brazilian culture to continue work started by Luís da Câmara Cascudo, still in 1921, when he started his career as a prefacer.

"Macanas", "tragedias" y "dramas" : Los jueces y su presentación del pasado de terrorismo de Estado en el Juicio por la Verdad de Bahía Blanca, Argentina

El trabajo que aquí se presenta tiene como objetivo indagar en las diferentes manifestaciones sobre el pasado reciente de terrorismo de Estado realizadas por los jueces durante las audiencias de uno de los denominados "Juicios por la Verdad", que se realizó en la ciudad de Bahía Blanca, Argentina entre 1999 y 2000. Se trabajó con una metodología de análisis cualitativo y se utilizaron distintas fuentes de información tales como entrevistas a jueces y abogados de organizaciones de derechos humanos y la totalidad de los videos de las audiencias del Juicio por la Verdad de Bahía Blanca. Como resultado se establece la manera en que estos profesionales del derecho interpretaron el terrorismo de Estado confrontando la posición adoptada por los militares de no brindar información y de reivindicar la "guerra antisubversiva", deslindando a la vez las distintas responsabilidades entre los miembros de las Fuerzas Armadas.

Abundance of organic-walled dinoflagellate cysts in surface sediments from the Atlantic sector of the Southern Ocean (Appendix 2)

Thirty-two surface sediment samples from the Southern Ocean (eastern Atlantic sector), between the Subtropical Front and the Weddell Gyre, were investigated to provide information on the distribution of modern organic-walled dinoflagellate cysts in relation to the oceanic fronts of the Antarctic Circumpolar Current (ACC). A clearly distinguishable distribution pattern was observed in relation to the water masses and fronts of the ACC. The dinoflagellate cysts of species characteristic of open oceanic environments, such as Impagidinium species, are highly abundant around the Subtropical Front, whereas south of this front, cosmopolitan species such as Nematosphaeropsis labyrinthus and the cysts of Protoceratium reticulatum characterise the transition from subtropical to subantarctic surface waters. The subantarctic surface waters are dominated by the cysts of heterotrophic dinoflagellates, such as Protoperidinium spp. and Selenopemphix antarctica. The cysts of Protoperidinium spp. form the dominant part of the assemblages around the Antarctic Polar Front, whereas S. antarctica concentrations increase further to the south. The presence of S. antarctica in sediments of the Maud Rise, a region of seasonal sea-ice cover, reflects its tolerance for low temperatures and sea-ice cover. A previously undescribed species, Cryodinium meridianum gen. nov. sp. nov., has a restricted distribution pattern between the Antarctic Polar Front and the ACC-Weddell Gyre Boundary.

Biogeochemical, sedimentological and isotopic sediment record of Lake Dojran

A Late Glacial to Holocene sediment sequence (Co1260, 717 cm) from Lake Dojran, located at the boarder of the F.Y.R. of Macedonia and Greece, has been investigated to provide information on climate variability in the Balkan region. A robust age-model was established from 13 radiocarbon ages, and indicates that the base of the sequence was deposited at ca. 12 500 cal yr BP, when the lake-level was low. Variations in sedimentological (H2O, TOC, CaCO3, TS, TOC/TN, TOC/TS, grain-size, XRF, d18Ocarb, d13Ccarb, d13Corg) data were linked to hydro-acoustic data and indicate that warmer and more humid climate conditions characterised the remaining period of the Younger Dryas until the beginning of the Holocene. The Holocene exhibits significant environmental variations, including the 8.2 and 4.2 ka cooling events, the Medieval Warm Period and the Little Ice Age. Human induced erosion processes in the catchment of Lake Dojran intensified after 2800 cal yr BP.

(Table 1) Magnetic susceptibility, lithologic composition and stable isotope record for ODP Hole 132-810C

Site 810 was drilled atop Shatsky Rise during Ocean Drilling Program (ODP) Leg 132. The principal objective at Site 810 was to drill interbedded cherts and chalks of Mesozoic age using the diamond coring system (DCS). The objective was not achieved because of difficulties in setting up the reentry cone on the seafloor; however, a shortened section of Cretaceous-Cenozoic nannofossil ooze was recovered with the advanced piston corer (APC). Although the section is interrupted by hiatuses, the upper 50 m carry detailed information relating to biogenic productivity, water chemistry, and eolian input during the Pliocene and Pleistocene. Four holes were drilled at Site 810. Hole 810A consists of a single mud-line core for an ongoing ODP geriatric study. The second hole (Hole 810B) was washed to 60 mbsf (without core recovery) to provide information required for setting the 16-in. casing attached to the reentry cone. Hole 810C penetrated 136.1 mbsf, mostly with the APC, with a total recovery of 143.81 m of nannofossil ooze. A reentry cone was placed over Hole 810D but no casing was successfully suspended in the hole and no sediment was cored. This data report presents the results of shore-based high-resolution analyses of carbonate and oxygen isotopic variations in the upper 50 m of the section at Site 810 and compares these variations with the shipboard determinations of magnetic susceptibility and GRAPE bulk density from the multisensor track.

Activity concentrations of radionuclides in 5 short cores taken in 2007-2008 measured by ICP-MS and HPGe gamma spectrometry

Natural radionuclides and man-made 137Cs were analyzed in five short sediment cores taken in northern part of the Gulf of Eilat (Gulf of Aqaba) in order to provide information on sedimentation and mixing rates and sediment sources. The maximum estimates of sedimentation rates based on excess 210Pb were found to vary between 0.105 ± 0.020 and 0.35 ± 0.23 cm · year**-1. Even the lowest estimates are significantly higher than those expected from dust deposition, suggesting other sources and processes being responsible for most of the allochthonous material accumulation, including periodical floods following heavy rain events, internal erosion or triggers, like earthquakes. In 137Cs depth profiles no 1963 related nuclear weapon test maxima were found; instead, the activities decrease monotonically, suggesting that a major process leading to radionuclides' depth distribution might be mixing. The mixing rates calculated from 137Cs, excess 210Pb and excess 228Th reach values up to 2.18 ± 0.69 cm**2 · year**-1.

Pelagic phosphorus accumulation in the Pacific Ocean

As a limiting nutrient to marine life, phosphorus (P) is an effective tracer of today's marine productivity. The distribution of P in marine sediments likewise tracks the history of marine productivity because of its relative insolubility in seawater. CaCO3, biogenic opal, terrigenous sediment, and total P have been measured in cores from nine Pacific sites (Deep Sea Drilling Project (DSDP) 65, 66, 310, 77, 62, 572, 463, 586, and GPC-3) and one subantarctic (DSDP 266) site. These sites were specifically chosen to provide information on biota burial flux changes with time for sedimentary sinks that represent key oceanographic variables, i.e., rate of upwelling, water depth, and carbonate dissolution gradient. The accumulation rates of these components for the last 10 Ma were then calculated from determined core age versus depth plots, core bulk density, and porosity data. The accumulation of P weakly correlates with that of CaCO3, moderately with that of total sediment, and very strongly with carbonate-free accumulation. Two prominent peaks for all components occur at 2-3 Ma and 5-6 Ma, and record the chemical loading of dissolved CaCO3, SiO2, and P from glacially emergent continental shelves. These results indicate that continental shelf phosphorites form during interglacially high sea levels and correspond to low deep-sea P accumulation rates, whereas glacially lowered sea levels allow for shelf bypassing and greater deep-sea P accumulation rates.