Rumshisky`s Music Album. Litwack and Galitzianer

A. Schorr

Rumshisky`s Music Album. Mamenu. Including an Elegy to the Triangle Fire Victims. Violinsatz

A.Schorr

Synagogue Music. Yehi Rozon from Rosh Chodesh Benschen

Cantor Josef Rosenblatt

Die südafrikanischen Republiken : Buren-Freistaaten, für Deutschlands Export und Auswanderung ; Geschichte und Land der Buren ...

von M. Hans Klössel

Beethoven Society, Music

Signatur des Originals: S 36/F12232

William Crotch, This Celebrated Child who discover'd extraordinary Talents for Music during the Third Year of his Age, was born at Norwich July 5th. 1775.

Signatur des Originals: S 36/G03990

Ancient Music. Monarchs, who, with Rapture wild

Hear their own Prayse with Mouths of gaping Wonder / And catch each Crotchet of the Birth-day Thunder (Peter Pindar) [[Elektronische Ressource]]

Bey der höchst-beglückten Wiederkunfft des Durchlauchtigsten Fürsten und Herrn, Johann Wilhelms Hertzogen zu Sachsen, Jülich, Cleve und Berg nebst dero .. Frau Gemahlin ... aus Dero Saynischen Landen in Dero Residenz zu Eisenach : welche den 22. Augusti 1722 ... erfolgte ; wollte ihre untertänigste Devotion in einer Cantata zur Tafel-Music bezeugen ; die sämmtliche Hoch-Fürstliche Capelle

[Georg Philipp Telemann]

The role of the conserved N -terminal domain of STAT3 in STAT3 dephosphorylation and nuclear export

Rapid redistribution of STAT subcellular localization is an essential feature of cytokine signaling. To elucidate the molecular basis of STAT3 function, which plays a critical role in controlling innate immune responses in vivo, we initiated studies to determine the mechanisms controlling STAT3 nuclear trafficking. We found that STAT3 is transported to the nucleus in the absence of cytokine treatment, as judged by indirect immunofluorescence studies in the presence of leptomycin B, an inhibitor of CRM1-dependent nuclear export, suggesting that the non-phosphorylated STAT3 protein contains a functional nuclear import signal. An isoform lacking the STAT3 N-terminal domain (Δ133STAT3) retains the ability to undergo constitutive nuclear localization, indicating that this region is not essential for cytokine-independent nuclear import. Δ133STAT3 is also transported to the nucleus following stimulation with interleukin-6 (IL-6). Interestingly, IL-6-dependent tyrosine phosphorylation of Δ133STAT3 appears to be prolonged and the nuclear export of the protein delayed in cells expressing endogenous STAT3, consistent with defective Δ133STAT3 dephosphorylation. Endogenous STAT3 does not promote the nuclear export of Δ133STAT3, although dimerization between endogenous Stat3 and Δ133STAT3 is detected readily. Thus, the STAT3 N-terminal domain is not required for dimerization with full-length STAT3, yet appears to play a role in proper export of Stat3 from the nucleus following cytokine stimulation. STAT3-deficient cells reconstituted with Δ133STAT3 show enhanced and prolonged Stat1 signaling in response to IL-6, suggesting that induction of the STAT3-dependent negative regulator SOCS3 is impaired. In fact, Δ133STAT3 fails to induce SOCS3 mRNA efficiently. These studies collectively indicate that the STAT3 N-terminal region may be important for IL-6-dependent target gene activation and nuclear dephosphorylation, while dispensable for nuclear import. STAT3 is an oncogene. STAT3 is constitutively activated in primary tumors of many types. Thus far, research in the design of STAT3 protein inhibitors has focused on the SH2 and DNA-binding domains of STAT3. Interference with these domains eliminates all signaling through STAT3. If the N-terminal domain is involved in tetramerization on a subset of target genes, inhibition of this region may lead to a more selective inhibition of some STAT3 functions while leaving others intact. ^

Net primary productivity, POC export, Th234 and U238 activities and abundance of autotrophs during U.S.C.G.C. Healy cruises HLY0802 and HLY0803

Seasonal patterns in the partitioning of phytoplankton carbon during receding sea ice conditions in the eastern Bering Sea water column are presented using rates of 14C net primary productivity (NPP), phototrophic plankton carbon content, and POC export fluxes from shelf and slope waters in the spring (March 30-May 6) and summer (July 3-30) of 2008. At ice-covered and marginal ice zone (MIZ) stations on the inner and middle shelf in spring, NPP averaged 76 ± 93 mmol C/m**2/d, and in ice-free waters on the outer shelf NPP averaged 102 ± 137 mmol C/m**2/d. In summer, rates of NPP were more uniform across the entire shelf and averaged 43 ± 23 mmol C/m**2/d over the entire shelf. A concomitant shift was observed in the phototrophic pico-, nano-, and microplankton community in the chlorophyll maximum, from a diatom dominated system (80 ± 12% autotrophic C) in ice covered and MIZ waters in spring, to a microflagellate dominated system (71 ± 31% autotrophic C) in summer. Sediment trap POC fluxes near the 1% PAR depth in ice-free slope waters increased by 70% from spring to summer, from 10 ± 7 mmol C/m**2/d to 17 ± 5 mmol C/m**2/d, respectively. Over the shelf, under-ice trap fluxes at 20 m were higher, averaging 43 ± 17 mmol C/m**2/d POC export over the shelf and slope estimated from 234Th deficits averaged 11 ± 5 mmol C/m**2/d in spring and 10 ± 2 mmol C/m**2/d in summer. Average e-ratios calculated on a station-by-station basis decreased by ~ 30% from spring to summer, from 0.46 ± 0.48 in ice-covered and MIZ waters, to 0.33 ± 0.26 in summer, though the high uncertainty prevents a statistical differentiation of these data.

Export of algal biomass from the melting Arctic sea ice

In the Arctic, under-ice primary production is limited to summer months and is not only restricted by ice thickness and snow cover but also by the stratification of the water column, which constrains nutrient supply for algal growth. RV Polarstern visited the ice-covered Eastern Central basins between 82 to 89°N and 30 to 130°E in summer 2012 when Arctic sea ice declined to a record minimum. During this cruise, we observed a widespread deposition of ice algal biomass of on average 9 g C per m**2 to the deep-sea floor of the Central Arctic basins. Data from this cruise will contribute to assessing the impact of current climate change on Arctic productivity, biodiversity, and ecological function.