Cahiers philosophiques / V. Lénine ; [publié par l'Institut de marxisme-léninisme près le Comité central du Parti communiste de l'U.R.S.S.]

Titre original : Filosofskie tetradi

Marked increase of the astrocytic marker S100B in the cerebrospinal fluid of HIV-infected patients on LPV/r-monotherapy.

OBJECTIVE: To determine changes of cerebrospinal fluid (CSF) biomarkers of patients on monotherapy with lopinavir/ritonavir. DESIGN: The Monotherapy Switzerland/Thailand study (MOST) trial compared monotherapy with ritonavir-boosted lopinavir with continued therapy. The trial was prematurely stopped due to virological failure in six patients on monotherapy. It, thus, offers a unique opportunity to assess brain markers in the early stage of HIV virological escape. METHODS: : Sixty-five CSF samples (34 on continued therapy and 31 on monotherapy) from 49 HIV-positive patients enrolled in MOST. Using enzyme-linked immunosorbent assay, we determined the CSF concentration of S100B (astrocytosis), neopterin (inflammation), total Tau (tTau), phosphorylated Tau (pTau), and amyloid-β 1-42 (Aβ), the latter three indicating neuronal damage. Controls were CSF samples of 29 HIV-negative patients with Alzheimer dementia. RESULTS: In the CSF of monotherapy, concentrations of S100B and neopterin were significantly higher than in continued therapy (P = 0.006 and P = 0.013, respectively) and Alzheimer dementia patients (P < 0.0001 and P = 0.0005, respectively). In Alzheimer dementia, concentration of Aβ was lower than in monotherapy (P = 0.005) and continued therapy (P = 0.016) and concentrations of tTau were higher than in monotherapy (P = 0.019) and continued therapy (P = 0.001). There was no difference in pTau among the three groups. After removal of the 16 CSF with detectable viral load in the blood and/or CSF, only S100B remained significantly higher in monotherapy than in the two other groups. CONCLUSION: Despite full viral load-suppression in blood and CSF, antiretroviral monotherapy with lopinavir/ritonavir can raise CSF levels of S100B, suggesting astrocytic damage.

[Stade] R[ue] Olivier de Serres [Paris, 15e arrondissement], 1-2-20, [football] association, équipe [de] l'Olympique Lillois : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57846

Assistência ao surdo na área de saúde como fator de inclusão social

Este estudo objetivou discutir a assistência ao surdo na área de saúde como fator de inclusão social; investigar junto aos surdos como se estabelece o vínculo com os profissionais da saúde; verificar percepções dos surdos quanto à presença de intérpretes de língua de sinais, quando recebem assistência à saúde. Pesquisa descritivo-analítica, com abordagem qualitativa realizada em uma escola especial em Goiânia. A amostra constou de 20 alunos surdos e a entrevista semi-estruturada foi utilizada para coletar os dados. Constatou-se que o vínculo é estabelecido quando os profissionais conseguem comunicar-se com os surdos; a inclusão do surdo nos serviços de saúde evidencia dificuldades de comunicação. Concluiu-se que a relação profissional cliente precisa ser melhorada; que o vínculo ocorre quando o cliente se sente compreendido e que a presença do intérprete melhora, mas não contribui totalmente para a inclusão social do surdo.