Noninvasive Evaluation of Oral Lesions Using Depth-sensitive Optical Spectroscopy

BACKGROUND: Optical spectroscopy is a noninvasive technique with potential applications for diagnosis of oral dysplasia and early cancer. In this study, we evaluated the diagnostic performance of a depth-sensitive optical spectroscopy (DSOS) system for distinguishing dysplasia and carcinoma from non-neoplastic oral mucosa. METHODS: Patients with oral lesions and volunteers without any oral abnormalities were recruited to participate. Autofluorescence and diffuse reflectance spectra of selected oral sites were measured using the DSOS system. A total of 424 oral sites in 124 subjects were measured and analyzed, including 154 sites in 60 patients with oral lesions and 270 sites in 64 normal volunteers. Measured optical spectra were used to develop computer-based algorithms to identify the presence of dysplasia or cancer. Sensitivity and specificity were calculated using a gold standard of histopathology for patient sites and clinical impression for normal volunteer sites. RESULTS: Differences in oral spectra were observed in: (1) neoplastic versus nonneoplastic sites, (2) keratinized versus nonkeratinized tissue, and (3) shallow versus deep depths within oral tissue. Algorithms based on spectra from 310 nonkeratinized anatomic sites (buccal, tongue, floor of mouth, and lip) yielded an area under the receiver operating characteristic curve of 0.96 in the training set and 0.93 in the validation set. CONCLUSIONS: The ability to selectively target epithelial and shallow stromal depth regions appeared to be diagnostically useful. For nonkeratinized oral sites, the sensitivity and specificity of this objective diagnostic technique were comparable to that of clinical diagnosis by expert observers. Thus, DSOS has potential to augment oral cancer screening efforts in community settings. Cancer 2009;115:1669-79. (C) 2009 American Cancer Society.

PARALLEL ALGORITHMS FOR MAXIMAL CLIQUES IN CIRCLE GRAPHS AND UNRESTRICTED DEPTH SEARCH

We present parallel algorithms on the BSP/CGM model, with p processors, to count and generate all the maximal cliques of a circle graph with n vertices and m edges. To count the number of all the maximal cliques, without actually generating them, our algorithm requires O(log p) communication rounds with O(nm/p) local computation time. We also present an algorithm to generate the first maximal clique in O(log p) communication rounds with O(nm/p) local computation, and to generate each one of the subsequent maximal cliques this algorithm requires O(log p) communication rounds with O(m/p) local computation. The maximal cliques generation algorithm is based on generating all maximal paths in a directed acyclic graph, and we present an algorithm for this problem that uses O(log p) communication rounds with O(m/p) local computation for each maximal path. We also show that the presented algorithms can be extended to the CREW PRAM model.

Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder

Objective: Abnormalities in the morphology and function of two gray matter structures central to emotional processing, the perigenual anterior cingulate cortex (pACC) and amygdala, have consistently been reported in bipolar disorder (BD). Evidence implicates abnormalities in their connectivity in BD. This study investigates the potential disruptions in pACC-amygdala functional connectivity and associated abnormalities in white matter that provides structural connections between the two brain regions in BD. Methods: Thirty-three individuals with BD and 31 healthy comparison subjects (HC) participated in a scanning session during which functional magnetic resonance imaging (fMRI) during processing of face stimuli and diffusion tensor imaging (DTI) were performed. The strength of pACC-amygdala functional connections was compared between BD and HC groups, and associations between these functional connectivity measures from the fMRI scans and regional fractional anisotropy (FA) from the DTI scans were assessed. Results: Functional connectivity was decreased between the pACC and amygdala in the BD group compared with HC group, during the processing of fearful and happy faces (p < .005). Moreover, a significant positive association between pACC-amygdala functional coupling and FA in ventrofrontal white matter, including the region of the uncinate fasciculus, was identified (p < .005). Conclusion: This study provides evidence for abnormalities in pACC-amygdala functional connectivity during emotional processing in BD. The significant association between pACC-amygdala functional connectivity and the structural integrity of white matter that contains pACC-amygdala connections suggest that disruptions in white matter connectivity may contribute to disturbances in the coordinated responses of the pACC and amygdala during emotional processing in BD.

Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging

Background Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder. Aims To test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum. Method Fractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging. Results Fractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups. Conclusions Our findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cingulate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum.

Photocatalyst TiO(2)-Co: the effect of doping depth profile on methylene blue degradation

In this work, we study the effect of doping depth profile on the photocatalytic and surface properties of TiO(2) films. Two thin film layers of TiO(2) (200 nm) and Co (5 nm), respectively, were deposited by physical evaporation on glass substrate. These films were annealed for 1 s at 100 and 400 A degrees C and the Co layer was removed by chemical etching. Atomic force microscopy (AFM) phase images showed changes in the surface in function of thermal treatment. The grazing-incidence X-ray fluorescence (GIXRF) measurements indicated that the thermal treatment caused migration of Co atoms to below the surface, the depths found were between 19 and 29 nm. The contact angle showed distinct values in function of the doped profile or Co surface concentration. The UV-vis spectra presented a red shift with the increasing of thermal treatment. Photocatalytical assays were performed by methylene blue discoloration and the higher activity was found for TiO(2)-Co treated at 400 A degrees C, the ESI-MS showed the fragments formed during the methylene blue decomposition.

3D roll-forming of hat-profile with variable depth and width

The use of roll-formed products in automotive, furniture, buildings etc. increases every year due to the low part-production cost and the complicated cross-sections that can be produced. The limitation with roll-forming until recent years is that one could only produce profiles with a constant cross-section in the longitudinal direction. About eight years ago ORTIC AB [1] developed a machine in which it was possible to produce profiles with a variable width (“3D roll-forming”) for the building industry. Experimental equipment was recently built for research and prototyping of profiles with variable cross-section in both width and depth for the automotive industry. The objective with the current study is to investigate the new tooling concept that makes it possible to roll-form hat-profiles, made of ultra high strength steel, with variable cross-section in depth and width. The result shows that it is possible to produce 3D roll-formed profiles with close tolerances.

Medical students are afraid to include abortion in their future practices : in-depth interviews in Maharastra, India

BACKGROUND: Unsafe abortions are estimated to cause eight per-cent of maternal mortality in India. Lack of providers, especially in rural areas, is one reason unsafe abortions take place despite decades of legal abortion. Education and training in reproductive health services has been shown to influence attitudes and increase chances that medical students will provide abortion care services in their future practice. To further explore previous findings about poor attitudes toward abortion among medical students in Maharastra, India, we conducted in-depth interviews with medical students in their final year of education. METHOD: We used a qualitative design conducting in-depth interviews with twenty-three medical students in Maharastra applying a topic guide. Data was organized using thematic analysis with an inductive approach. RESULTS: The participants described a fear to provide abortion in their future practice. They lacked understanding of the law and confused the legal regulation of abortion with the law governing gender biased sex selection, and concluded that abortion is illegal in Maharastra. The interviewed medical students' attitudes were supported by their experiences and perceptions from the clinical setting as well as traditions and norms in society. Medical abortion using mifepristone and misoprostol was believed to be unsafe and prohibited in Maharastra. The students perceived that nurse-midwives were knowledgeable in Sexual and Reproductive Health and many found that they could be trained to perform abortions in the future. CONCLUSIONS: To increase chances that medical students in Maharastra will perform abortion care services in their future practice, it is important to strengthen their confidence and knowledge through improved medical education including value clarification and clinical training.

Escolha de canais de venda em comércio eletrônico

The electronic commerce has become a channel of advertising, commercialization and distribution of products and services, continuously increasing it¿s importance in terms of both physical and financial volumes, but still exist many gaps in the knowledge about the choice process of sales channels in the electronic commerce. The objective of this work is to raise and quantify the relevant factors in the choice of these channels in Brazil. The identification of the relevant factors was made through depth interviews with consumers, users of electronic commerce, as well as through the existing theoretical referential on the subject. The quantification of these factors was carried out with book purchasers by electronic commerce, through quantitative research, using the methodology of conjoint analysis, where the price was the most important factor, followed by delivery time, positive experience on previous purchase, usability of the site, positive recommendation of friends and the site brand. These results indicate as important attributes: price, confidence, usability and brand.

Avaliação qualitativa e quantitativa do colágeno total, tipo I e III da linha alba em pacientes portadores de hérnia da parede abdominal anterior

No presente trabalho foram colhidas amostras da aponeurose da linha alba abdominal de 26 pacientes com idades entre 26 e 75 anos, portadores de hérnias da parede abdominal anterior, para avaliação qualitativa e quantitativa do colágeno total, tipo I e III. Oito desses pacientes foram operados no Hospital de Clínicas de Porto Alegre (HCPA), quatro no Hospital Pompéia de Caxias do Sul (HP) e 14 na Clínica Particular do autor (CPA) em Caxias do Sul. Todos os pacientes eram portadores de hérnias da parede abdominal anterior, sendo seis casos de hérnias incisionais, 11 casos de hérnias umbilicais e sete casos de hérnias epigástricas, um caso com duas hérnias: incisional e epigástrica e um outro caso também com duas hérnias, sendo uma epigástrica e outra umbilical. As amostras foram retiradas na linha média da linha alba, três centímetros acima da cicatriz umbilical e outra a dois centímetros abaixo dessa cicatriz. Uma vez no laboratório, as amostras foram subdivididas em duas. Em uma delas realizou-se a avaliação quantitativa do colágeno total e na outra a avaliação qualitativa dos colágenos tipo I e III. A avaliação quantitativa foi realizada por meio da coloração com picrosirius e contagem das fibras colágenas em microscópio de luz polarizada e análise digital por birrefringência, tendo sido utilizado o aplicativo Image Pro Plus (Media Cybernetics, Silver Spring, USA). A avaliação qualitativa foi feita por meio da imuno-histoquímica, com a utilização de anticorpos monoclonais anticolágeno tipo I e III. Os achados obtidos nesses pacientes foram comparados com os achados obtidos em um grupo-controle de cadáveres não formolizados do Instituto Médico Legal de Caxias do Sul. No grupo-controle de cadáveres sem hérnias, foram realizados os mesmos estudos dos pacientes cirúrgicos portadores de hérnias, para avaliar as diferenças das quantidades de colágeno total, tipo I e III entre os dois grupos. Os resultados mostraram que as quantidades de colágeno total eram 18,05% menores nos pacientes com hérnias da parede anterior do abdome, quando comparados com o grupo-controle de cadáveres sem hérnias (p  0,05). Já as quantidades do colágeno tipo I foram 20,50% menores nos pacientes (p  0,05). O mesmo ocorreu com o colágeno tipo III que apresentou uma percentagem 7,3% menor nesses mesmos pacientes (p = 0,383).

Permanência de alunos nos cursos presenciais e a distância em Administração: contribuições para a gestão acadêmica

A educação a distância vem ganhando destaque nos últimos anos em função da capacidade de expansão do ensino superior e também por incluir um grupo de pessoas que, de outra forma, não poderia realizar uma graduação. O objetivo dessa pesquisa é identificar as variáveis que influenciam o processo de permanência dos alunos de Administração, comparando resultados das modalidades presencial e a distância, tomando como caso a Universidade Estadual do Maranhão (Uema). Como principal referencial teórico do presente estudo, escolheu-se o Modelo de Integração do Estudante de Tinto (1975), considerado como a primeira proposta academicamente reconhecida de determinação das variáveis que intervém no processo de evasão e permanência de alunos em um curso de graduação. Um dos componentes do modelo despertou o interesse de comparação entre as duas modalidades (presencial e a distância) de forma especial, qual seja: a integração social, decorrente das interações discentes e docentes, que em geral são pouco exploradas nos estudos empíricos. O método definido para o estudo foi de caráter descritivo e base qualitativa. A submissão do conjunto de variáveis observadas na literatura a uma análise de juízes resultou na definição de três principais Dimensões e 60 Componentes, a saber: (1) Perfil do aluno; (2) Estar-em-rede; e (3) Condições para a permanência. Essas variáveis compuseram o quadro de análise de conteúdo categorial, resultante da aplicação de múltiplos instrumentos de coleta de dados (dois questionários e uma entrevista em profundidade), que foram utilizados na triangulação com dados secundários obtidos no próprio Enade (2009). Como contribuição teórica da presente tese, aponta-se a possibilidade de integração das três visões filosóficas: Cognitivismo, Construtivismo e Conectivismo que se interrelacionam na gestão acadêmica de cursos superiores pela unicidade da educação vislumbrada pelo blended learning como tendência futura para a educação superior. Outras contribuições são apresentadas em relação aos componentes: atributos individuais, trabalho e estágio, contexto familiar, escolaridade anterior, uso das TICs, interação docente e discente, compromisso pessoal e institucional e integração acadêmica.

Avenues to success : electoral strategies and ambition in the Brazilian chamber of deputies

In the second consecutive election for the Brazilian Chamber ofDeputies, the majority of incumbents (75% in 1998 and again 75% in 2002) decided to run for reelection and at least 70% ofthem in both elections were successful, suggesting thus it would be incorrect to ignore static ambition as the main target of Brazilian legislators. It also raises doubts about the assertion that incumbents use their posts to pursue their post-Iegislative careers. However, this number also suggests that not alIlegislators seek reelection, indicating that it is also incorrect to assume alI of them are driven by similar motivations. In their attempts at career survival, incumbents may also run for higher offices (Senator, Governor, Vicegovernor). A minority still, may run for state leveI offices (regressive ambition).Given that static and progressive ambition are the two main types of career choice in Brazil, we focus on the factors that influence the career decision and electoral success of those who choose to run for reelection and those who choose to run for higher-level offices, i.e. senator and governor. We use data recently colIected from the 2002 elections.