Lake Van deep drilling project PALEOVAN

A complete succession of the lacustrine sediment sequence deposited during the last ∼600,000 years in Lake Van, Eastern Anatolia (Turkey) was drilled in 2010 supported by the International Continental Scientific Drilling Program (ICDP). Based on a detailed seismic site survey, two sites at a water depth of up to 360 m were drilled in summer 2010, and cores were retrieved from sub-lake-floor depths of 140 m (Northern Basin) and 220 m (Ahlat Ridge). To obtain a complete sedimentary section, the two sites were multiple cored in order to investigate the paleoclimate history of a sensitive semi-arid region between the Black, Caspian, and Mediterranean seas. This introductory paper provides background information of the deep drilling project and an overview of the studies presented in this special volume by the PALEOVAN science team dealing with chronology, paleomagnetism, paleoenvironmental proxies, geophysical and petrophysical investigations as well as pore-water and fluid transport.

De Opuscula van Daniel Levi (Miguel) de Barrios

[M. Roest]

Voornaamste letterkundige producten van wijlen M. Roest

door J. M. Hillesum

Eenige blikken in de negentiende aflevering van het "Beredeneerd Hebr. - en Chald. - Nederl. - Woordenboek bewerkt naar de Grammaticale en Lexicale Werken von Fürst, Landau, Gesenius, Vater en anderen, door I. Waterman"

Philip Elte

Neurotologic and functional MRI findings in a patient with bilateral profound deafness having Brown-Vialetto-Van Leare syndrome

INTRODUCTION We report the first findings of functional magnetic resonance imaging of the auditory cortex in a young woman with a bilateral cochleovestibular deficit as first manifestation of Brown-Vialetto-Van Leare syndrome. The patient had no open speech discrimination, even with hearing aids, and is depending on lip reading for communication. METHODS To evaluate the possible efficiency of a cochlear implantation, we investigated hemodynamic responses within the central auditory pathways using an auditory functional magnetic resonance imaging paradigm. RESULTS Blood oxygen level-dependent correlates were detected bilaterally along the auditory pathways after exposure to intermittent clicking tone stimulation at 2 kHz. CONCLUSION These results suggest integrity of the central auditory pathways and represent a positive argument to propose a cochlear implantation with the aim to restore hearing.

Leerrede over de tijdsomstandigheden van ons Vaderland, uitgesproken in de kerk zijner gemeente in de Portugeesche en in die van Middelburg, in de Nederlandsche taal

door A.C. Carillon

Hebreeuwsch-Nederduitsch Handwoordenboek : voorafgegaan van eene spraakkunstige handleiding ...

door M. Lemans en S. I. Mulder

De finantieele positie van den israel. godsdienstonderwijzer : Rede uitgespr. op de 8e algemeene vergadering van "Achawah" ... te Hilversum, op Dinsdag 14 Menachem 5656 (30 Juli 1901)

door A. van Creveld

Should the standard dimethyl sulfoxide concentration be reduced? Results of a European Group for Blood and Marrow Transplantation prospective noninterventional study on usage and side effects of dimethyl sulfoxide.

BACKGROUND Dimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient. STUDY DESIGN AND METHODS In this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marrow Transplant Group centers undertaking autologous transplantation on patients with myeloma and lymphoma and analyze side effects after return of DMSO-preserved stem cells. RESULTS While the majority of centers continue to use 10% DMSO, a significant proportion either use lower concentrations, mostly 5 or 7.5%, or wash cells before infusion (some for selected patients only). In contrast, the median dose of DMSO given (20 mL) was much less than the upper limit set by the same institutions (70 mL). In an accompanying statistical analysis of side effects noted after return of DMSO-preserved stem cells, we show that patients in the highest quartile receiving DMSO (mL and mL/kg body weight) had significantly more side effects attributed to DMSO, although this effect was not observed if DMSO was calculated as mL/min. Dividing the myeloma and lymphoma patients each into two equal groups by age we were able to confirm this result in all but young myeloma patients in whom an inversion of the odds ratio was seen, possibly related to the higher dose of melphalan received by young myeloma patients. CONCLUSION We suggest better standardization of preservation method with reduced DMSO concentration and attention to the dose of DMSO received by patients could help reduce the toxicity and morbidity of the transplant procedure.

Const Boeck, Nyeulijck wten alchemistichschen gront vergadert : tracterende van allen grondtlijcken ghebruyckinghe der consten ...

Gecolligiert ende eensdeels getranslateert door Symonem Andree

Gedenkschrift : uitgegeven ter gelegenheid van het 300-jarig bestaan der onderwijsinrichtingen Talmud Tora en Ets Hai͏̈m bij de Port. Israe͏̈l. Gemeente te Amsterdam : 5376 - 5676

M. C. Paraira en J. S. da Silva Rosa