Annales de l'Institut national agronomique : administration, enseignement et recherche

1929 (SER2,T22).

Annales de l'Institut national agronomique : administration, enseignement et recherche

1878 (A3,N4)-1879.

Annales de l'Institut national agronomique : administration, enseignement et recherche

1881 (N7,A6)-1882.

Annales de l'Institut national agronomique : administration, enseignement et recherche

1925 (SER2,T19).

Annales de l'Institut national agronomique : administration, enseignement et recherche

1884 (A9,N11)-1886 (A10,N11).

Annales de l'Institut national agronomique : administration, enseignement et recherche

1936 (SER2,VOL44,T28).

Annales de l'Institut national agronomique : administration, enseignement et recherche

1907 (SER2,T6,FASC1).

Can the administration be trusted? An analysis of the concept of trust, applied to the public sector

In the first part of this paper, we present the various academic debates and, where applicable, questions that remain open in the literature, particularly regarding the nature of trust, the distinction between trust and trustworthiness, its role in specific relationships and its relationship to control. We then propose a way of demarcating and operationalizing the concepts of trust and trustworthiness. In the second part, on the basis of the conceptual clarifications we present, we put forward a number of "anchor points" regarding how trust is apprehended in the public sector with regard to the various relations hips that can be studied. Schematically, we distinguish between two types of relations hips in the conceptual approach to trust: on one hand, the trust that citizens, or third parties, place in the State or in various public sector authorities or entities, and on the other hand, trust within the State or the public sector, between its various authorities, entities, and actors. While studies have traditionally focused on citizens' trust in their institutions, the findings, limitations and problems observed in public - sector coordination following the reforms associated with New Public Management have also elicited growing interest in the study of trust in the relationships between the various actors within the public sector. Both the theoretical debates we present and our propositions have been extracted and adapted from an empirical comparative study of coordination between various Swiss public - service organizations and their politico - administrative authority. Using the analysis model developed for this specific relationship, between various actors within the public service, and in the light of theoretical elements on which development of this model was based, we propose some avenues for further study - questions that remain open - regarding the consideration and understanding of citizens' trust in the public sector.

New cationic nanovesicular systems containing lysine-based surfactants for topical administration: Toxicity assessment using representative skin cell lines

Many strategies for treating diseases require the delivery of drugs into the cell cytoplasm following internalization within endosomal vesicles. Thus, compounds triggered by low pH to disrupt membranes and release endosomal contents into the cytosol are of particular interest. Cationic nanovesicles have attracted considerable interest as effective carriers to improve the delivery of biologically active molecules into and through the skin. In this study, lipid-based nanovesicles containing three different cationic lysine-based surfactants were designed for topical administration. We used representative skin cell lines and in vitro assays to assess whether the cationic compounds modulate the toxic responses of these nanocarriers. The nanovesicles were characterized in both water and cell culture medium. In general, significant agglomeration occurred after 24 h incubation under cell culture conditions. We found different cytotoxic responses among the formulations, which depended on the surfactant,cell line (3T3, HaCaT, and THP-1) and endpoint assayed (MTT, NRU, and LDH). Moreover, no potential phototoxicity was detected in fibroblast or keratinocyte cells, whereas only a slight inflammatory response was induced, as detected by IL-1a and IL-8 production in HaCaT and THP-1 cell lines, respectively. A key finding of our research was that the cationic charge position and the alkyl chain length of the surfactants determine the nanovesicles resulting toxicity. The charge on the a-amino group of lysine increased the depletion of cell metabolic activity, as determined by the MTT assay, while a higher hydrophobicity tends to enhance the toxic responses of the nanovesicles. The insights provided here using different cell lines and assays offer a comprehensive toxicological evaluation of this group of new nanomaterials.

Annuaire-Chaix : annuaire officiel des chemins de fer publié par l'administration de l'Imprimerie centrale des Chemins de fer

1852-1853.

Annuaire des postes, ou Manuel du service de la poste aux lettres : à l'usage du commerce et des voyageurs / publié par ordre de l'administration

1843.

Annuaire des postes, ou Manuel du service de la poste aux lettres : à l'usage du commerce et des voyageurs / publié par ordre de l'administration

1901.

Annuaire encyclopédique : politique, économie sociale, statistique, administration, sciences, littérature, beaux-arts, agriculture, commerce, industrie / publié par les directeurs de l'Encyclopédie du XIXe siècle

1861.