Gottfried Kinkel, sein Leben, sein Wirken

Welsch (Projektbearbeiter): Drei Erzählungen in einem Band: Biographie des republikanischen Dichters und Kunsthistorikers Kinkel, Darstellung der Dresdner Mairevolution 1849 sowie eine 'politische Novelle'

Berichtigende Erklärung: Eine anonyme Schrift: "Signatura temporis", hat in einer andern Schrift ...

Welsch (Projektbearbeiter): Darstellung der Geschehnisse am 18. und 19. März 1848 in Berlin (Massendemonstrationen und Ausbruch von Straßenkämpfen, Abzug der Truppen aus Berlin, Einsetzung des neuen Ministeriums) aus der Sicht des Grafen Arnim-Boitzenburg

Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes

Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and associate with increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes mellitus and up to 46,061 without diabetes, followed by functional studies. Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (p=2.4*10(-10)). Gene-by-diabetes interactions were detected and confirmed for variants in HS6ST1 and near RAB38/CTSC. SNPs at these loci demonstrated a genetic effect on UACR in individuals with but not without diabetes. The change in average UACR per minor allele was 21% for HS6ST1 and 13% for RAB38/CTSC (p=6.3*10(-7) and 5.8*10(-7), respectively). Experiments using streptozotocin-treated diabetic Rab38 knockout and control rats showed higher urinary albumin concentrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 knockout vs. control rats. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared to controls. The loci identified here confirm known and highlight novel pathways influencing albuminuria.

Der Redacteur der schwarzgelben Geißel: Die schwarzgelbe Fahne. Zusammenlauf: Entrüstung wegen dieses Reactions-Versuches: Der Redacteur der Geißel hat sich durch Verbreitung seiner schwarzgelben Tendenzen ...

Welsch (Projektbearbeiter): Meldung über das gewaltsame Eindringen in die Redaktion des Blattes 'Die Geißel' aus Anlaß der dortigen Hissung des Symbols der Reaktion, einer 'schwarzgelben' (eigentlich schwarz-goldenen) Fahne. Grundsätzlich positive Haltung zu den Geschehnissen

Wieder eine brennende Lunte zwischen Bürger, Nationalgarde und akademische Legion: Zum größten Erstaunen hat Herr Latour in der heutigen Reichstagsversammlung vorgebracht ...

Welsch (Projektbearbeiter): Scharfe Zurückweisung der Behauptung des Kriegsministers Latour, in der Wiener Universität habe eine Versammlung mit dem Ziel stattgefunden, das Ministerium zu stürzen und den Reichstag zu sprengen: "Ich fordere daher Herrn Latour ... auf, seine nicht gar schmeichelhafte Aussage zu beweisen, und ... ein anderesmal mit mehr Vorsicht die Feuerlunten unter das Volk zu streuen"

Der Gemeinderath der Stadt Wien, von mehreren Seiten aufgefordert, den Anmarsch der ungarischen Truppen anzuordnen ...

Welsch (Projektbearbeiter): Der Wiener Gemeinderat erklärt sich in der Frage des Oberbefehls über die ungarischen Truppen für nicht zuständig und weist auf die laufenden Beratungen des entscheidungsbefugten Gremiums, des permanenten Reichstagsausschusses hin

Kundmachung: Alle k. k. von Conducteuren geleiteten Postwägen ...

Welsch (Projektbearbeiter): Anordnung, Posttransporte nach und aus Wien ungehindert passieren zu lassen

Kundmachung: Alle öffentlichen Cassen, alle Wohlthätigkeitsfonde und Institute, überhaupt alles öffentliche und Privat-Eigenthum ...

Welsch (Projektbearbeiter): Aufruf an die Wiener Bevölkerung zur Achtung fremden Eigentums

Detection of haemorrhagic shock: Are vital signs obsolete? A commentary by Dr M. Luginbühl

The ATLS program by the American college of surgeons is probably the most important globally active training organization dedicated to improve trauma management. Detection of acute haemorrhagic shock belongs to the key issues in clinical practice and thus also in medical teaching. (In this issue of the journal William Schulz and Ian McConachrie critically review the ATLS shock classification Table 1), which has been criticized after several attempts of validation have failed [1]. The main problem is that distinct ranges of heart rate are related to ranges of uncompensated blood loss and that the heart rate decrease observed in severe haemorrhagic shock is ignored [2]. Table 1. Estimated blood loos based on patient's initial presentation (ATLS Students Course Manual, 9th Edition, American College of Surgeons 2012). Class I Class II Class III Class IV Blood loss ml Up to 750 750–1500 1500–2000 >2000 Blood loss (% blood volume) Up to 15% 15–30% 30–40% >40% Pulse rate (BPM) <100 100–120 120–140 >140 Systolic blood pressure Normal Normal Decreased Decreased Pulse pressure Normal or ↑ Decreased Decreased Decreased Respiratory rate 14–20 20–30 30–40 >35 Urine output (ml/h) >30 20–30 5–15 negligible CNS/mental status Slightly anxious Mildly anxious Anxious, confused Confused, lethargic Initial fluid replacement Crystalloid Crystalloid Crystalloid and blood Crystalloid and blood Table options In a retrospective evaluation of the Trauma Audit and Research Network (TARN) database blood loss was estimated according to the injuries in nearly 165,000 adult trauma patients and each patient was allocated to one of the four ATLS shock classes [3]. Although heart rate increased and systolic blood pressure decreased from class I to class IV, respiratory rate and GCS were similar. The median heart rate in class IV patients was substantially lower than the value of 140 min−1 postulated by ATLS. Moreover deterioration of the different parameters does not necessarily go parallel as suggested in the ATLS shock classification [4] and [5]. In all these studies injury severity score (ISS) and mortality increased with in increasing shock class [3] and with increasing heart rate and decreasing blood pressure [4] and [5]. This supports the general concept that the higher heart rate and the lower blood pressure, the sicker is the patient. A prospective study attempted to validate a shock classification derived from the ATLS shock classes [6]. The authors used a combination of heart rate, blood pressure, clinically estimated blood loss and response to fluid resuscitation to classify trauma patients (Table 2) [6]. In their initial assessment of 715 predominantly blunt trauma patients 78% were classified as normal (Class 0), 14% as Class I, 6% as Class II and only 1% as Class III and Class IV respectively. This corresponds to the results from the previous retrospective studies [4] and [5]. The main endpoint used in the prospective study was therefore presence or absence of significant haemorrhage, defined as chest tube drainage >500 ml, evidence of >500 ml of blood loss in peritoneum, retroperitoneum or pelvic cavity on CT scan or requirement of any blood transfusion >2000 ml of crystalloid. Because of the low prevalence of class II or higher grades statistical evaluation was limited to a comparison between Class 0 and Class I–IV combined. As in the retrospective studies, Lawton did not find a statistical difference of heart rate and blood pressure among the five groups either, although there was a tendency to a higher heart rate in Class II patients. Apparently classification during primary survey did not rely on vital signs but considered the rather soft criterion of “clinical estimation of blood loss” and requirement of fluid substitution. This suggests that allocation of an individual patient to a shock classification was probably more an intuitive decision than an objective calculation the shock classification. Nevertheless it was a significant predictor of ISS [6]. Table 2. Shock grade categories in prospective validation study (Lawton, 2014) [6]. Normal No haemorrhage Class I Mild Class II Moderate Class III Severe Class IV Moribund Vitals Normal Normal HR > 100 with SBP >90 mmHg SBP < 90 mmHg SBP < 90 mmHg or imminent arrest Response to fluid bolus (1000 ml) NA Yes, no further fluid required Yes, no further fluid required Requires repeated fluid boluses Declining SBP despite fluid boluses Estimated blood loss (ml) None Up to 750 750–1500 1500–2000 >2000 Table options What does this mean for clinical practice and medical teaching? All these studies illustrate the difficulty to validate a useful and accepted physiologic general concept of the response of the organism to fluid loss: Decrease of cardiac output, increase of heart rate, decrease of pulse pressure occurring first and hypotension and bradycardia occurring only later. Increasing heart rate, increasing diastolic blood pressure or decreasing systolic blood pressure should make any clinician consider hypovolaemia first, because it is treatable and deterioration of the patient is preventable. This is true for the patient on the ward, the sedated patient in the intensive care unit or the anesthetized patients in the OR. We will therefore continue to teach this typical pattern but will continue to mention the exceptions and pitfalls on a second stage. The shock classification of ATLS is primarily used to illustrate the typical pattern of acute haemorrhagic shock (tachycardia and hypotension) as opposed to the Cushing reflex (bradycardia and hypertension) in severe head injury and intracranial hypertension or to the neurogenic shock in acute tetraplegia or high paraplegia (relative bradycardia and hypotension). Schulz and McConachrie nicely summarize the various confounders and exceptions from the general pattern and explain why in clinical reality patients often do not present with the “typical” pictures of our textbooks [1]. ATLS refers to the pitfalls in the signs of acute haemorrhage as well: Advanced age, athletes, pregnancy, medications and pace makers and explicitly state that individual subjects may not follow the general pattern. Obviously the ATLS shock classification which is the basis for a number of questions in the written test of the ATLS students course and which has been used for decades probably needs modification and cannot be literally applied in clinical practice. The European Trauma Course, another important Trauma training program uses the same parameters to estimate blood loss together with clinical exam and laboratory findings (e.g. base deficit and lactate) but does not use a shock classification related to absolute values. In conclusion the typical physiologic response to haemorrhage as illustrated by the ATLS shock classes remains an important issue in clinical practice and in teaching. The estimation of the severity haemorrhage in the initial assessment trauma patients is (and was never) solely based on vital signs only but includes the pattern of injuries, the requirement of fluid substitution and potential confounders. Vital signs are not obsolete especially in the course of treatment but must be interpreted in view of the clinical context. Conflict of interest None declared. Member of Swiss national ATLS core faculty.

An Seine Excellenz den Banus von Croatien, Baron Jelachich: Auf die am heutigen Tage von Euer Excellenz und dem Grafen Auersperg unterzeichnete Zuschrift ...

Welsch (Projektbearbeiter): Antwort des Reichstages auf ein Schreiben von Jellačić: Der Reichstag hat alle seine Kräfte aufgeboten, um die Bevölkerung vor Feindseligkeiteng gegen das Militär abzubringen. Gegen die Zernierung Wiens, die Entwaffnung der Nationalgarden der umliegenden Ortschaften sowie die dortigen Requisitionen muß er seinen entschiedenen Protest einlegen. Was die Frage des Eindringens ungarischer Truppen nach Österreich betrifft, so bleibt festzustellen, daß der Reichstag die Ungarn nicht ins Land gerufen hat und sie daher auch nicht "hinaus decretiren" kann. Frieden ist nur durch den sofortigen Rückzug Jellačićs nach Kroatien sowie die vorherige Wiederbewaffnung der Nationalgarden möglich. Geschieht dies nicht, ist ein Kampf mit den ungarischen Truppen unvermeidlich

Laternenlied: Mit Feuer: 1. Sie ler-nen nichts, sie ler-nen nichts die Herrn Hochwohl-ge-bo-ren! Ver-geb-lich schmettert des Ge-richts Po-sau-ne ih-ren Oh-ren ...

Welsch (Projektbearbeiter): Abdruck eines Revolutionsliedes (nach dem Vorbild des französischen 'Ça ira' von 1789): "Weil denn die Herrn vom bes-sern Blut die neu-e Zeit nicht ler-nen: drum hängt die Herren kurz und gut ... hoch, hoch an die La-ter-nen!" Vgl. dazu Dunder, W. G.: Denkschrift über die Wiener October-Revolution; Wien 1849 S. 36: "Dieses Gedicht erschien abgedruckt im politischen Studenten-Courier vom 4. October [1848], Nr. 91, redigirt von Adolf Buchheim und Oscar Falke [recte Georg Peter] ..."

Vegetation and fire history of coastal north-eastern Sardinia (Italy) under changing Holocene climates and land use

Little is known about the vegetation and fire history of Sardinia, and especially the long-term history of the thermo-Mediterranean belt that encompasses its entire coastal lowlands. A new sedimentary record from a coastal lake based on pollen, spores, macrofossils and microscopic charcoal analysis is used to reconstruct the vegetation and fire history in north-eastern Sardinia. During the mid-Holocene (c. 8,100–5,300 cal bp), the vegetation around Stagno di Sa Curcurica was characterised by dense Erica scoparia and E. arborea stands, which were favoured by high fire activity. Fire incidence declined and evergreen broadleaved forests of Quercus ilex expanded at the beginning of the late Holocene. We relate the observed vegetation and fire dynamics to climatic change, specifically moister and cooler summers and drier and milder winters after 5,300 cal bp. Agricultural activities occurred since the Neolithic and intensified after c. 7,000 cal bp. Around 2,750 cal bp, a further decline of fire incidence and Erica communities occurred, while Quercus ilex expanded and open-land communities became more abundant. This vegetation shift coincided with the historically documented beginning of Phoenician period, which was followed by Punic and Roman civilizations in Sardinia. The vegetational change at around 2,750 cal bp was possibly advantaged by a further shift to moister and cooler summers and drier and milder winters. Triggers for climate changes at 5,300 and 2,750 cal bp may have been gradual, orbitally-induced changes in summer and winter insolation, as well as centennial-scale atmospheric reorganizations. Open evergreen broadleaved forests persisted until the twentieth century, when they were partly substituted by widespread artificial pine plantations. Our results imply that highly flammable Erica vegetation, as reconstructed for the mid-Holocene, could re-emerge as a dominant vegetation type due to increasing drought and fire, as anticipated under global change conditions.

1850

Boberach: Behandelt werden nach "Intoleranten Glossen über Toleranz" von Walesrode u.a. "Die gesellschaftliche Stellung der Frauen" von Ehrenreich [i.e. Ehrenfried] Eichholz, die Errichtung von Volksbanken, die Beziehungen zu Polen und Ungarn, die Berliner Arbeiter-Verbrüderung, die Zivilehe, der Gründer der "Freien Gemeinde" in Halle Gustav Adolf Wislicenus, Arnold Ruges "Jugend und Kerkerleben", die Untergrabung der Volksfreiheit durch die Kirche, der Prozeß Waldecks, der Krieg in Schleswig-Holstein; eingestreut sind 12 Gedichte von H. Zeise, davon 3 über Polen

Die Stimme des Herrn der Herren : Heerpredigt an die Deutschen

von G. C. A. Harleß