« Memoires pour la navigation et le commerce de France ».

Contient : « Table des memoires qui seront contenus en ce recueil » ; « Establissement de la compagnie des Anglois trafiquans ès Indes Orientales et les privileges octroyez à lad. compagnie pour 15 ans par Elizabeth, royne d'Angleterre. A Westmonster, à Londres, l'an 1600, le 31 decembre ». Résumé « extraict des Navigations et voyages des Anglois et autres, recueillis par Purchas et imprimez à Londres l'an 1625 » ; « Privileges octroyez par Michel Federwitz, empereur de Moscovie, à la compagnée des marchans anglois trafiquans en Moscovie. En la ville de Mosco, l'an 1620, le 11 de may ». Résumé « extrait des Navigations de Purchas » ; « Traicté de paix entre Michel Federwitz, empereur de Moscovie, et Gustave Adolphe, roy de Suede. A Stalbo, l'an 1616, le 27 febvrier ». Résumé « extraict des Navigations de Purchas » ; « Des empeschemens et difficultez qui se rencontrent au commerce de France en Moscovie » ; « De la pesche et du commerce des François en l'Amerique, devers la riviere de Canada ou de Sainct Laurent et devers l'isle de Terre Neuve ou Neufondlande, et comme les Anglois les y peuvent empescher. 1611-1621 » ; Blanc ; « Des usurpations des Anglois sur les François en la Nouvelle France, en l'Amerique, depuis l'an 1611 » ; « Don de la Nouvelle Escosse, cy devant comprise soubs le nom de la Nouvelle France, par JACQUES, roy de la Grand Bretagne, à Guillaume Alexandre, seigneur escossois. A Vindesore, l'an 1621, le 10 de septembre ». Acte en latin. Copie ; « Que la Nouvelle France et l'isle de Terre Neuve ont esté descouvertes par les François, dès l'an 1504 ». Extraits de « la Refutation de Pierre Plancius, cosmographe, contre les pretentions des Anglois pour la pesche ès costes de Spitzberg » et du livre Ier de l'Histoire de Bretagne de « Bertrand d'Argentré » ; « Traictez entre les roys de France et d'Angleterre, concernant les pyrateries et de predations sur mer et aussi touchant les lettres de represailles et de marque ; « Traicté entre Louys XII, roy de France, et HENRI VIII, roy d'Angleterre, concernant les pyrateries et depredations sur mer entre leurs subjects, ratifié par ledictroy Henry, à Westmonstier, l'an 1498, le 24 d'aoust ». En latin ; Art. 6, 9, 10, 13, 14 du « traicté de paix et de confederation et alliance entre Charles IX, roy de France, et Elizabeth, royne d'Angleterre, à Troyes, l'an 1564, le 11 d'apvril, ratifié par ladicte Elizabeth à Richemond, audict an, le 27 dudict mois ». En latin ; « Traicté entre Henry le Grand, roy de France, et Elizabeth, royne d'Angleterre, concernant les pyrateries et depredations sur mer, l'an 1600, extraict de l'Histoire de ladicte royne Elizabeth de Guillaume Camden, imprimée à Leyden, l'an 1625, p. 766-767 » ; « Extraict du traicté d'alliance et confederation entre Louys XIII, roy de France, et Jacques, roy de la Grande Bretagne, ratifié par le roy Louys XIII, à Paris, l'an 1610, le 14 de septembre » ; « Compagnées en Angleterre, Holande, Espagne et autres royaumes pour le trafic et commerce en divers pays » ; « Establissement es Provinces Unies des Pays-Bas d'une compagnée pour le trafic ès Indes Orientales, l'an 1602 »

Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels.

BACKGROUND Cavalier King Charles Spaniels (CKCS) have a high prevalence of inherited macrothrombocytopenia. The purpose of this study was to determine if a mutation in beta1-tubulin correlated with presumptive inherited macrothrombocytopenia. HYPOTHESIS A mutation in beta1-tubulin results in synthesis of an altered beta1-tubulin monomer. alpha-beta tubulin dimers within microtubule protofilaments are unstable, resulting in altered megakaryocyte proplatelet formation. ANIMALS Blood samples were obtained from CKCS and non-CKCS dogs. METHODS DNA was used in polymerase chain reaction (PCR) assays to evaluate beta1-tubulin. Platelet numbers and mean platelet volume (MPV) were evaluated for a correlation with the presence or absence of a mutation identified in beta1-tubulin. Platelets obtained from homozygous, heterozygous, and clear CKCS were further evaluated using electron microscopy and immunofluorescence. RESULTS A mutation in the gene encoding beta1-tubulin correlated with macrothrombocytopenia in CKCS. Electron microscopy and immunofluorescence studies suggest that platelet microtubules are present but most likely are unstable and decreased in number. CONCLUSIONS AND CLINICAL IMPORTANCE The macrothrombocytopenia of CKCS correlated with a mutation in beta1-tubulin. alpha-beta tubulin dimers within protofilaments most likely are unstable, leading to altered proplatelet formation by megakaryocytes. This information will aid in distinguishing inherited from acquired thrombocytopenia. It also provides insight into the mechanism of platelet production by megakaryocytes, and also may prove useful in understanding heart-related changes in macrothrombocytopenic CKCS with concurrent mitral valve regurgitation.

On the accession of Charles Emanuel the IVth to the throne = In occasione dell' avvenimento al trono dell' augustissimo sovrano Carlo Emmanuele IV.

Verses in English signed: Frances Negri Gobbet. Italian translation signed: Aretofilo Dianeo (?--print unclear)

The reform act, 1832; the correspondence of the late Earl Grey with His Majesty King William IV. and with Sir Herbert Taylor, from Nov. 1830 to June 1832;

Mode of access: Internet.

Reminiscences of the court and times of King Ernest of Hanover /

Mode of access: Internet.

Memoirs of Mrs. Fitzherbert; with an account of her marriage with H. R. H. the Prince of Wales, afterwards King George IV.

Mode of access: Internet.

Diary of Samuel Pepys, F.R.S., secretary to the Admiralty in the reigns of Charles II & James II.

Introduction by Richard Garnett.

The romance of history : France /

--Bertha ; or, The court of Charlemagne.--The last of the Breton kings.--The adventures of Eriland.--The man-wolf.--The king of the beggars.--The serf.--The pilgrim of Saint James.--The bondsman's feast.--The phantom fight.--The magic wand.--The rock of the fort.--The dream-girl.--The black mask ; or, the lottery of jewels.

Les sources de l'histoire de France des origines aux guerres d'Italie (1494)

t. I. Époque primitive. Mérovingiens et Carolingiens. 1901.--t. II. Époque féodale. Les Capétiens jusqu'en 1180. 1902.--t. III. Les Capétiens, 1180-1328. 1903.--t. IV. Les Valois, 1328-1461. 1904.--t. V. Introduction générale. Les Valois (suite) Louis XI et Charles VIII (1461-1491) 1904.--t. VI. Table générale, par Louis Polain. 1906.

The Lyon in mourning; or, A collection of speeches, letters, journals, etc. relative to the affairs of Prince Charles Edward Stuart,

Mode of access: Internet.

The life and correspondence of Rufus King; comprising his letters, private and official, his public documents, and his speeches.

"Of this letter-press ed. 750 copies have been printed for sale."

Five Stuart princesses : Margaret of Scotland, Elizabeth of Bohemia, Mary of Orange, Henrietta of Orleans, Sophia of Hanover /

Margaret, daughter of James I. of Scotland, dauphine of France, by H. E. Butler.--Elizabeth of Bohemia, daughter of James I. and VI., by R. H. Hodgkin.--Mary of Orange, daughter of Charles I. and mother of William III., by A. Cecil.--Henrietta of Orleans, daughter of Charles I., by J. S. C. Bridge.--Sophia of Hanover, grand-daughter of James I. and VI., and mother of George I., by the editor.

The novels of Samuel Richardson, esq. viz. Pamela, Clarissa Harlowe, and Sir Charles Grandison. In three volumes. To which is prefixed, a memoir of the life of the author.

In Ballantyne's novelist's library. [London, 1821-24] 25 cm. vol. VI-VIII.

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Sepsis is the leading cause of death in intensive care units and results from a deleterious systemic host response to infection. Although initially perceived as potentially deleterious, catalytic antibodies have been proposed to participate in removal of metabolic wastes and protection against infection. Here we show that the presence in plasma of IgG endowed with serine protease-like hydrolytic activity strongly correlates with survival from sepsis. Variances of catalytic rates of IgG were greater in the case of patients with severe sepsis than healthy donors (P < 0.001), indicating that sepsis is associated with alterations in plasma levels of hydrolytic IgG. The catalytic rates of IgG from patients who survived were significantly greater than those of IgG from deceased patients (P < 0.05). The cumulative rate of survival was higher among patients exhibiting high rates of IgG-mediated hydrolysis as compared with patients with low hydrolytic rates (P < 0.05). An inverse correlation was also observed between the markers of severity of disseminated intravascular coagulation and rates of hydrolysis of patients' IgG. Furthermore, IgG from three surviving patients hydrolyzed factor VIII, one of which also hydrolyzed factor IX, suggesting that, in some patients, catalytic IgG may participate in the control of disseminated microvascular thrombosis. Our observations provide the first evidence that hydrolytic antibodies might play a role in recovery from a disease.