1000 resultados para COMPOSTOS QUÍMICOS E DROGAS


Relevância:

20.00% 20.00%

Publicador:

Resumo:

Chemistry is a experimental science and should be taught emphasizing the experimental work at laboratories. Brazilian teachers either in secondary level teaching as well at University gave minor attention in laboratory experiments as a tool to improve the quality of the teaching. Adelino Leal published a monograph in 1926 which emphasizes the experimental work in the teaching of Chemistry. The French chemist Jungfleisch had a important influence in the Adelino Leal's work and was the main reference for both his work and published books.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

By using thermochemical data reported for a series of chelates of the type [Ln(thd)3], thd = 2, 2, 6, 6 ­ tetramethyl- 3,5-heptanedione and Ln = La, Pr, Nd, Sm, Gd, Tb, Ho, Er, Tm and Yb, empirical correlations were found involving thermochemical parameters (e.g. dissociation enthalpy) and the thermodynamic temperatures of the beginning of thermal degradation of the chelates, t i. It is shown that t i values are of capital importance in the study of this all class of coordination compounds. Among others, the empirical equation is obtained: r3+ = (-0,013.Z + 1,36)/0,005, that relates the lanthanide cation radius (pm) with the atomic number of the element. The remarkable fact is that this equation is achieved by using thermogravimetric and calorimetric parameters. Is also shown that t i values are related with the P(M) function values, which are very close related with the energy difference, deltaE, between the lowest electronic energy level of the f n s²d¹ configuration and the lowest energy level of the f n+1s² configuration in the neutral gaseous atoms.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Independent of the sample form (powder or film), XRD analysis of Ir0,3Ti(0,7-x)Ce xO2, (nominal) mixtures, for x=0, shows the formation of a solid solution phase between IrO2 and TiO2, as well as the rutile phases of IrO2 and TiO2. The presence of the anatase phase of TiO2 is also confirmed. The introduction of 30 mol% CeO2 in the mixture reveals the presence of the CeO2 and Ce2O3 phases, besides the already mentioned ones, in the powder. In the film form, however, an amorphous phase is identified. When all of the TiO2 is substituded by CeO2, for both sample forms, the only phases found are IrO2, CeO2 and Ce2O3. This result suggests cerium oxides are not capable of forming solid solutions with either IrO2 or (Ir,Ti)O2 acting solely as a dispersant matrix for these phases. These results are consistent with the much higher electrochemically active surface area when CeO2 is introduced in the binary Ti/Ir0,3Ti0,7O2 mixture. It was possible to establish a relationship between the electrochemical stability of the supported films and their crystalline structure. The unexpected presence of TiO2 and Ti2O3 in the Ti/Ir0,3Ce0,7O2 (film sample) is attributed to oxidation of the Ti support during the calcination step.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Water Quality Index (WQI) was used during summer and winter of 1994 and 1995 in the final section of Onça and Feijão streams, downstream Broa Reservoir (São Carlos/SP) to evaluate agricultural and catlleman effects. In Onça stream water quality was "acceptable" in winter and "inappropriate to conventional treatment" in the summer. In Feijão stream the water had an "excellent" quality in winter and "good" in the summer. A MANOVA (Multivariate Analysis of Variance) has used to discriminate seasons and streams. Correlation (p<0,05) among the variables was tested. Water temperature, turbidity, pH and fecal bacteria are highly correlated and can be one of the factors that cause WQI change by seasons.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Analysis of alcohols, esters and carbonyl compounds were performed using HRGC and HPLC techniques in samples of fusel oils from three different Brazilian alcohol distilleries. High content of isoamyl alcohol (390 g.L-1), isobutyl alcohol (158 g.L-1), ethyl alcohol (28,4 g.L-1), methyl alcohol (16,6 g.L-1) and n-propyl alcohol (11,9 g.L-1) were found. These compounds represent 77 ± 8 % of the approximated weight of a liter of fusel oils. The obtained results show the feasibility of using fusel oils as low-cost raw material for the synthesis of chemicals.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

When organic compounds present in biological fluids are analysed by chromatographic methods, it is generally necessary to carry out a prior sample preparation due the high complexity of this type of sample, especially when the compounds to be determinated are found in very low concentrations. This article describes some of the principal methods for sample preparation in analyses of substances present in biological fluids. The methods include liquid-liquid extraction, solid phase extraction, supercritical fluid extraction and extraction using solid and liquid membranes. The advantages and disadvantages of these methods are discussed.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Phenols are widely used in many areas and commonly found as industrial by-products. A great number of agricultural and industrial activities realise phenolic compounds in the environmental. Waste phenols are produced mainly by the wood-pulp industry and during production of synthetic polymers, drugs, plastics, dyes, pesticides and others. Phenols are also released into the environmental by the degradation of pesticides with phenolic skeleton. The phenols level control is very important for the environmental protection. Amperometric biosensor has shown the feasibility to complement laboratory-based analytical methods for the determination of phenolic compounds, providing alternatives to conventional methods which have many disadvantages. This brief review considers the evolution of an approach to amperometric measurement using the catalytic properties of some enzymes for phenolic compounds monitoring.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

It was evaluated the applicability of Langmuir, Freundlich and Temkin models to copper adsorption in three classes of soils. Fractions of each soil were added to test tubes containing growing concentrations of the metal in solution. The tubes were shaken and the copper concentrations were determined in the extracts by atomic absorption spectrometry (AAS). The models offered a good fit for the experimental data indicating that presence of silicated clay had high influence on copper sorption. The Langmuir isotherm showed high influence of the organic matter in the absorption phenomenon. It was evidenced the importance of further studies related to Temkin model.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Gustavia augusta is used in the folk medicine against leishmaniosis and showed anti-inflammatory action. The phytochemical studies of the plant stem bark have led to the isolation of (22E)-stigmasta-7,22-dien-3beta-ol, 24alpha(S)-ethyl-5alpha-colesta-7,trans-22-dien-3-one, D-friedoolean-14-en-3beta-ol, D-friedoolean-14-en-3-one and D-friedoolean-14-en-3alpha-ol along with stigmasterol, alpha-amyrin, beta-amyrin, lupeol, 3alpha-hidroxi-lupeol and betulinic acid. The structures of these compounds were identified by IR, GC/MS, ¹H and 13C NMR spectral analysis and comparison with literature data.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The structures of seven oleanene and ursene triterpenoids (1-7) isolated from aerial parts of Mentha villosa were identified. In addition, the complete ¹H and 13C resonance assignments of these triterpenoids were accomplished using 1D and 2D NMR spectroscopic experiments.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

This paper provides a brief review of the chemistry of cyclopentadienyl Sn(II) derivatives which includes the preparation, the molecular structure and reactivity associated with such bis-sandwich tin(II) species. It is compared structural and spectroscopic results and it is also discussed how the nature of the cyclopentadienyl ring bonded to the Sn centre plays an important role in the structural and stability features of the derivatives. Bulk rings such as C5HPr i4- , C5Bz5-, C5Me4SiMe2Bu t- and C5Ph5- render air-stable and parallel ring-bonded compounds.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Diazocarbonyl compounds are a very important class of organic substances which have a long history of useful aplications in organic chemistry. The focus of this report deals with the use of diazocarbonyl compounds in a ariety of important reactions and their application in organic synthesis. These reactions are briefly summarized showing their broad scope.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The main purpose of this work was the qualitative study of organic compounds in landfill leachate. The samples were collected from a sanitary landfill located at Gravataí, a southern Brazilian city, that receive both, industrial and domestic refuse. The samples were submitted to solid phase extraction (SPE) with XAD-4 resin as the stationary phase. The instrumental analysis was performed by Gas Chromatography with a Mass Spectrometry Detector (GC/MSD). The compounds achieved in the SPE extracts were tentatively identified by the GC/MS library. It was found several oxygen and nitrogen compounds like carboxylic acids, ketones, amines and amides. Sulfur compounds and phthalate esters are also identified.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The reactions of four new unsymmetrical N,O-donor ligands, {H2BBPETEN= [N-(2-hydroxybenzyl) - N,N' - bis(2 methylpyridyl) -N'-(hydroxyethyl) ethylenodiamine], H3BPETEN=[N,N'- bis(2-hydroxybenzyl) -N- (2-methylpyridyl) -N'- (hydroxyethyl) ethylenodiamine], HTPETEN=[N,N,N'- tris(2-methylpyridyl) -N'- (hydroxyethyl) ethylenodiamine] and H3BIMETEN=[N,N'-(2-hydroxybenzyl)-N-(1-methylimidazol-2-il-methyl)-N'- (hydroxyethyl)ethylenodiamine]}, with Cu(II) salts afforded the following mononuclear compounds: [CuII(HBBPETEN)]ClO4, [CuII(H2BPETEN)]ClO4 , [CuII(HTPETEN)](PF6)2 and [CuII(H2BIMETEN)]ClO4 . All were characterized by EPR, electronic spectroscopy and electrochemistry. The four copper (II) compounds showed interesting electrochemistry properties. All presented an anodic wave that can be attributed to the Cu (I) oxide formation at the electrode surface, or to a Cu0 sediment at the same surface or yet, to Cu(I) -> Cu(II) oxidation process with coupled chemistry reaction, due to their irreversibility. Two of the complexes are described as interesting synthetic models for the active site of the metalloenzyme galactose oxidase.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Organosulfur compounds present in garlic and onion have been evaluated as inhibitors of chemical carcinogenesis. Among them diallylsulfide was mainly investigated and studies demonstrated its metabolization to the corresponding sulfoxide and sulfone. In this work, we report the investigation of the interaction between the diallylsulfide and its oxidized derivatives, through cyclic voltammetry, with horse heart cytocrome-c (on a modified electrode with 4-mercaptopyridine). Our results suggest that there is a reversible interaction between cytocrome-c and diallylsulfide and diallylsulfone and an irreversible interaction with the diallylsulfoxide.