Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes.

Vertebrate limbs develop in a temporal proximodistal sequence, with proximal regions specified and generated earlier than distal ones. Whereas considerable information is available on the mechanisms promoting limb growth, those involved in determining the proximodistal identity of limb parts remain largely unknown. We show here that retinoic acid (RA) is an upstream activator of the proximal determinant genes Meis1 and Meis2. RA promotes proximalization of limb cells and endogenous RA signaling is required to maintain the proximal Meis domain in the limb. RA synthesis and signaling range, which initially span the entire lateral plate mesoderm, become restricted to proximal limb domains by the apical ectodermal ridge (AER) activity following limb initiation. We identify fibroblast growth factor (FGF) as the main molecule responsible for this AER activity and propose a model integrating the role of FGF in limb cell proliferation, with a specific function in promoting distalization through inhibition of RA production and signaling.

Changes Measurement in Biological Signals Based on Dynamic Time Warping Procedure on the Example of Repolarization Part of HeartbeatCycle

Master thesis discusses the analysis of changes in biological signals on time based on dynamic time warping algorithm (DTW). Special attention is paid to problems of tiny changes analysis incomplex nonstationary biological signals. Electrocardiographic (ECG) signals are used as an example inthis study; in particular, repolarization segments of heart beat cycles. The aim of the research is studyingthe possibility of applying DTW algorithm for the analysis of small changes in the repolarization segments of heart beat cycles. The research has the following tasks:- Studying repolarization segments of heart beat cycles, andmethods of their analysis;- Studying DTW algorithm and its modifications, finding the most appropriate modification for analyzing changes in biological signals;- Development of methods for analyzing the warping path(output parameter of DTW algorithm).

Similarity Measurement of Biological Signals Using Dynamic Time Warping Algorithm

The problem of similarity measurement of biological signals is considered on this article. The dynamic time warping algorithm is used as a possible solution. A short overview of this algorithm and its modifications are given. Testing procedure for different modifications of DTW, which are based on artificial test signals, are presented.

Left turn signals for Arizona. Final report.

Arizona Department of Transportation, Phoenix

Automatic audio signing - literature survey analysis. Interim report, phase 1, task A.

Federal Highway Administration, Washington, D.C.

Driver understanding of work zone flagger signals and signaling devices. Interim report.

Texas State Department of Highways and Public Transportation, Transportation Planning Division, Austin

Using light emitting diodes in traffic signals -- final report.

Federal Highway Administration, Washington, D.C.

Look, listen and learn; a manual on the use of audio-visual materials in informal education,

Mode of access: Internet.

Visibility and spacing of lane control signals for freeway traffic management.

Texas Department of Transportation, Austin

User guide for removal of not needed traffic signals.

Federal Highway Administration, Washington, D.C.

Bibliographies on nursing; books, pamphlets, articles, audio-visual materials.

A replacement for, rather than an addition to, the bibliographies of the former National Organization for Public Health Nursing, the National League of Nursing Education, 1952, and the National League for Nursing, 1954-55.

Bibliographies on nursing; books, pamphlets, articles, audio-visual aids.

Vol. 5 issued by the National League for Nursing, Division of Nursing Education.

A study of clearance intervals, flashing operation, and left-turn phasing at traffic signals. Volume 1: sumary report. Final report.

Federal Highway Administration, Office of Research and Development, Washington, D.C.