Volume of Traffic on the Primary Road System, 2002

The Office of Transportation Data, in cooperation with the Federal Highway Administration, prepares this biennial traffic report. This report is used by federal, state, and local governmental agencies in determining highway needs, construction priorities, route location and environmental impact studies, and the application of appropriate design standards. The general public uses this information in determining the amount of traffic that passes a given area as they make their development plans and propose land use changes. The above reflects only a few of the many technical uses for this data.

A non-randomized direct comparison of cognitive-behavioral short- and long-term treatment for binge eating disorder

Background: To compare treatment outcomes of a cognitive-behavioral long-term (CBT-L) and short-term (CBT-S) treatment for binge eating disorder (BED) in a non-randomized comparison and to identify moderators of treatment outcome. Methods: 76 female patients with BED participated in the study: 40 in CBT-L and 36 in CBT-S. Outcome values were compared at the end of the active treatment phase (16 sessions for CBT-L, 8 sessions for CBT-S) and at 12-month follow-up. Results: Both treatments produced significant reductions in binge eating. At the end of active treatment, but not at the end of follow-up, effects of primary outcomes (e.g. remission from binge eating, EDE shape concern) were better for CBT-L than for CBT-S. Dropout rates were significantly higher in CBT-L (35%) than in CBT-S (14%). Moderator analyses revealed that treatment efficacy for rapid responders and individuals exhibiting high scores on the mixed dietary negative affect subtype differed between the CBT-L and CBT-S with respect to objective binges, restraint eating and eating concern. Conclusion: Findings suggest that CBT in general represents an effective treatment for BED, but that subgroups of patients might profit more from a prolonged treatment. Short, lessintensive CBT treatments could nevertheless be a viable option in the treatment of BED.

Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease.

OBJECTIVE: Inflammatory bowel diseases (IBDs), Crohn's disease, and ulcerative colitis (UC), are multifactorial disorders, characterized by chronic inflammation of the intestine. A number of genetic components have been proposed to contribute to IBD pathogenesis. In this case-control study, we investigated the association between two common vitamin D-binding protein (DBP) genetic variants and IBD susceptibility. These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT>GAG; Asp>Glu) and 420 (ACG>AAG; Thr>Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases. METHODS: Using TaqMan SNP technology, we have genotyped 884 individuals (636 IBD cases and 248 non-IBD controls) for the two DBP variants. RESULTS: On statistical analysis, we observed that the DBP 420 variant Lys is less frequent in IBD cases than in non-IBD controls (allele frequencies, P=0.034; homozygous carrier genotype frequencies, P=0.006). This inverse association between the DBP 420 Lys and the disease remained significant, when non-IBD participants were compared with UC (homozygous carrier genotype frequencies, P=0.022) or Crohn's disease (homozygous carrier genotype frequencies, P=0.016) patients separately. Although the DBP position 416 alone was not found to be significantly associated with IBD, the haplotype DBP_2, consisting of 416 Asp and 420 Lys, was more frequent in the non-IBD population, particularly notably when compared with the UC group (Odds ratio, 4.390). CONCLUSION: Our study adds DBP to the list of potential genes that contribute to the complex genetic etiology of IBD, and further emphasizes the association between vitamin D homeostasis and intestinal inflammation.

Cis-configured aziridines are new pseudo-irreversible dual-mode inhibitors of Candida albicans secreted aspartic protease 2

A series of cis-configured epoxides and aziridines containing hydrophobic moieties and amino acid esters,were synthesized as new potential inhibitors of the secreted aspartic protease 2 (SAP2) of Candida albicans. Enzyme assays revealed the N- benzyl-3-phenyl-substituted aziridines 11 and 17 as the most potent inhibitors, with second-order inhibition, rate constants (k(2)) between 56000 and 12-1000 M-1 min(-1). The compounds were shown to be pseudo-irreversible dual-mode, inhibitors: the interm ediate esterified enzyme resulting from nucleophilic ring opening was hydrolyzed and yielded amino alcohols as transition state-mimetic reversible inhibitors. The results of docking studies with the ring-closed aziridine forms of the inhibitors suggest binding modes mainly dominated by hydrophobic interactions with the S1, S1' S2, and S2' subsites of the protease, and docking studies with the processed amino alcohol forms predict additional hydrogen bonds of the new hydroxy group to the active site Asp residues. C. albicans growth assays showed the compounds to decrease SAP2-dependent growth while not affecting SAP2-independent growth.

Flora de Cabo Verde - Plantas Vasculares. 67. Apiaceae

Er-vas frequentemente com cau!es sukados, muito raramente arbustos ou pequenasá rvores. Caulese m regra ocos ou com medulab em desenvolvida. Folhas alternas,e m regra muito divididas, ocasionalmentes implese , muito raramente, peltadas. Flores em umbelas simples ou mais frequentemente compostasr,a ramentev erticiladaso u capitadas,e m regra bissexuadams asp or vezes unissexuadapso r redu@o. Tubo do cálice unido ao ovário; limbo de 5 dentes em regra minúsculos ou ausentes. Pétalas 5, valvadas, epigínicas, brancas ou, raramente, amareladase, sverdeadaso u rosadaso u, muito raramente, azuis. Estames 5, livres, alternando com as pétalas; anteras 2-loculares, deiscentesp or fendas longitudinais. Estiletes 2, em regra divergentes, muitas vezes parcialmente unidos e frequentcmente com estilopódio bem desenvolvido. Ovario ínfero, Zlocular, com 1 óvulo pêndulo em cada lóculo. Fruto seco, em regra dividindo-se na maturacão em 2 mericarpos ligados a um carpóforo central resultante dos feixes vasculares principais do fruto. Os carpelosa presentamfr equentementec ostasb em desenvolvidase as paredes são providas em regra de canais oleíferos característicos. 0 fruto pode ser lateral- ou dorsahnentec omprimidoe ter asasla terais bem desenvolvidas ou apresentar espinhos ou ganchos. Sementes providas de endosperma oleoso abundante e com embriões muito pequenos. Familia com cerca de 418 génerose 3100e speciese, ssencialmentcea racterística dasr egiõest emperadamentqe uentesd o Globo. Facilmenter econhecível pelo hábito geralmente herbáceo, a disposicão característica das flores em umbelas e principalmente pelo fruto em regra divisivel em 2 mericarpos

Proyecto Esperanto

Desarrollo de una página web para la biblioteca Esperanto que permita la gestión integral de su catálogo de libros, usuarios, reservas y préstamos.

Available Building Catalog, Vol.1, 2009

IDED’s efforts to support the “Green” initiative includes reducing the number of communication pieces we print and mail. To support our efforts, register at http://www.iowalifechanging.com/subscriptions/login.asp to receive notice of future issues of the Available Building Catalog as they become available online.

Creació d'una biblioteca utilitzant tecnologies.NET

Solució per a la gestió integral d'una biblioteca utilitzant tecnologies Microsoft.NET (ASP.NET, MVC, Silverlight i WCF).

Iowa Public Library Statistics Pocket Digest, 2008

The information in this digest comes from the FY08 Iowa Annual Public Library Survey. It reflects the activities of 522 of the 543 public libraries in Iowa. Full details may be found at http://www.statelibraryofiowa.org/ld/statistics. Information for the national rankings on pages 3 to 4 comes from Public Libraries in the United States: Fiscal Year 2006 by the Institute of Museum and Library Services, Washington D.C., December 2008. http://harvester.census.gov/imls/pubs/pls/pub_detail.asp?id=121#