Emancipation und Religion der Juden oder das Judenthum und seine Gegner : ein Sendschreiben an Herrn Prof. Dr. Allioli ...

von [Lazar] Adler

Assimilation oder Nationaljudenthum?

Von S. Adler

Deutsches Lesebuch für israelitische Schulen : in 3 Abt.

hrsg. von L. Adler

Für und wider die jüdische Volksschule in Preußen

von S. Adler

Leitfaden für den israelitischen Religionsunterricht

von S. Adler

Die letzte Versammlung im alten und die erste Versammlung im neuen Gotteshause : zwei Vorträge vor und zur Einweihung der neuen Synagoge zu Wolfhagen am 28. Tischri 5620 (26. October 1859)

gehalten von L. Adler

Die siebenundsiebzig sogenannten Rabbiner und die Rabbiner-Versammlung

von A. Adler

Tiqqūnē šṭarōt : rabbinisch und deutsch

dem Druck übergeben von J. G. C. Adler ...

Auto de fé and Jew

by Elkan Nathan Adler

The chief rabbis of England : a lecture

delivered by H. Adler

The voice of America on Kishineff

ed. by Cyrus Adler

Cyclophosphamide: As bad as its reputation? Long-term single centre experience of cyclophosphamide side effects in the treatment of systemic autoimmune diseases

OBJECTIVES Despite new treatment modalities, cyclophosphamide (CYC) remains a cornerstone in the treatment of organ or life-threatening vasculitides and connective tissue disorders. We aimed at analysing the short- and long-term side-effects of CYC treatment in patients with systemic autoimmune diseases. METHODS Chart review and phone interviews regarding side effects of CYC in patients with systemic autoimmune diseases treated between 1984 and 2011 in a single university centre. Adverse events were stratified according to the "Common Terminology Criteria for Adverse Events" version 4. RESULTS A total of 168 patients were included. Cumulative CYC dose was 7.45 g (range 0.5-205 g). Gastro-intestinal side effects were seen in 68 events, hair loss occurred in 38 events. A total of 58 infections were diagnosed in 44/168 patients (26.2%) with 9/44 suffering multiple infections. Severity grading of infections was low in 37/58 cases (63.8%). One CYC-related infection-induced death (0.6%) was registered. Amenorrhoea occurred in 7/92 females (7.6%) with 5/7 remaining irreversible. In females with reversible amenorrhoea, prophylaxis with nafarelin had been administered. Malignancy was registered in 19 patients after 4.7 years (median, range 0.25-22.25) presenting as 4 premalignancies and 18 malignancies, 3 patients suffered 2 premalignancies/malignancies each. Patients with malignancies were older with a higher cumulative CYC dose. Death was registered in 28 patients (16.6%) with 2/28 probably related to CYC. CONCLUSIONS Considering the organ or life-threatening conditions which indicate the use of CYC, severe drug-induced health problems were rare. Our data confirm the necessity to follow-up patients long-term for timely diagnosis of malignancies. CYC side-effects do not per se justify prescription of newer drugs or biologic agents in the treatment of autoimmune diseases.

Le purpura thrombotique thrombocytopénique - un diagtnostic méconnu

Le purpura thrombotique thrombocytopénique (PTT) est un diagnostic caractérisé par une hémolyse micro-angiopathique, se traduisant par la présence d’une thrombocytopénie et d’une schizocytose au frottis sanguin. Une déficience de l’enzyme ADAMTS13, enzyme protéolytique du facteur de von Willebrand (vWF), a été caractérisée comme cause pathogénique. L’importance de l’examen visuel du frottis sanguin dans le cadre d’une suspicion clinique ou hématologique d’un PTT est soulignée car il semble que le PTT soit sous-diagnostiqué, surtout parmi les enfants et jeunes adultes. Des superpositions avec le syndrome hémolytique et urémique associé aux diarrhées (SHU D+) et le syndrome hémolytique et urémique atypique (SHUa) sont discutées. Une revue actuelle des démarches diagnostiques, des options thérapeutiques et des facteurs pronostiques du PTT et des SHU est finalement proposée.

Die Renaissance des alten hebräischen Lese-Unterrichts im Lichte der modernen Methodik : eine didaktische Studie

N. Adler