921 resultados para 95% confidence of sample values
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The "Hydroblack91" dataset is based on samples collected in the summer of 1991 and covers part of North-Western in front of Romanian coast and Western Black Sea (Bulgarian coasts) (between 43°30' - 42°10' N latitude and 28°40'- 31°45' E longitude). Mesozooplankton sampling was undertaken at 20 stations. The whole dataset is composed of 72 samples with data of zooplankton species composition, abundance and biomass. Samples were collected in discrete layers 0-10, 0-20, 0-50, 10-25, 25-50, 50-100 and from bottom up to the surface at depths depending on water column stratification and the thermocline depth. Zooplankton samples were collected with vertical closing Juday net,diameter - 36cm, mesh size 150 µm. Tows were performed from surface down to bottom meters depths in discrete layers. Samples were preserved by a 4% formaldehyde sea water buffered solution. Sampling volume was estimated by multiplying the mouth area with the wire length. Mesozooplankton abundance: The collected materia was analysed using the method of Domov (1959). Samples were brought to volume of 25-30 ml depending upon zooplankton density and mixed intensively until all organisms were distributed randomly in the sample volume. After that 5 ml of sample was taken and poured in the counting chamber which is a rectangle form for taxomomic identification and count. Large (> 1 mm body length) and not abundant species were calculated in whole sample. Counting and measuring of organisms were made in the Dimov chamber under the stereomicroscope to the lowest taxon possible. Taxonomic identification was done at the Institute of Oceanology by Asen Konsulov using the relevant taxonomic literature (Mordukhay-Boltovskoy, F.D. (Ed.). 1968, 1969,1972). The biomass was estimated as wet weight by Petipa, 1959 (based on species specific wet weight). Wet weight values were transformed to dry weight using the equation DW=0.16*WW as suggested by Vinogradov & Shushkina, 1987. Taxon-specific abundance: The collected material was analysed using the method of Domov (1959). Samples were brought to volume of 25-30 ml depending upon zooplankton density and mixed intensively until all organisms were distributed randomly in the sample volume. After that 5 ml of sample was taken and poured in the counting chamber which is a rectangle form for taxomomic identification and count. Copepods and Cladoceras were identified and enumerated; the other mesozooplankters were identified and enumerated at higher taxonomic level (commonly named as mesozooplankton groups). Large (> 1 mm body length) and not abundant species were calculated in whole sample. Counting and measuring of organisms were made in the Dimov chamber under the stereomicroscope to the lowest taxon possible. Taxonomic identification was done at the Institute of Oceanology by Asen Konsulov using the relevant taxonomic literature (Mordukhay-Boltovskoy, F.D. (Ed.). 1968, 1969,1972). The biomass was estimated as wet weight by Petipa, 1959 ussing standard average weight of each species in mg/m3. WW were converted to DW by equation DW=0.16*WW (Vinogradov ME, Sushkina EA, 1987).
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We have conducted an integrated paleomagnetic and biostratigraphic study on the Cenozoic sedimentary sequences of the southern Iberia Abyssal Plain margin, focusing on Ocean Drilling Program (ODP) Sites 897, 898, 900, 1067, 1068, and 1069. Reliable magnetostratigraphy from these six sites is presented in this paper. Sedimentary sections from Holes 897C, 898A, 900A, 1067A, 1068A, and 1069A have recorded a pattern of magnetic polarity reversals that correlates well with the known magnetic polarity timescale for the past 56 m.y. The polarity patterns from the Pliocene-Pleistocene turbidite sequence at the Leg 149 sites show that a reliable magnetostratigraphy can be established from the early Pliocene to Holocene, including the Gilbert/Gauss boundary (3.58 m.y.) through the Matuyama/Brunhes boundary (0.78 m.y.). On the basis of distinct intervals of magnetic reversal zones and biostratigraphic datums, five magnetozones (C21n-C25n) can be recognized at the three Leg 173 sites that range from middle Eocene to late Paleocene in age. The magnetostratigraphy of the Iberia sections allows the determination of sedimentation rates and better constraints on the timing of deformation. Combining the age and average inclination information available from the magnetostratigraphy, we also present paleolatitudes vs. time for the Iberia drill sites.
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Paleotemperature estimates based on coral Sr/Ca have not been widely accepted because the reconstructed glacial-Holocene shift in tropical sea-surface temperature (~4-6°C) is larger than that indicated by foraminiferal Mg/Ca (~2-4°C). We show that corals over-estimate changes in sea-surface temperature (SST) because their records are attenuated during skeletogenesis within the living tissue layer. To quantify this process, we microprofiled skeletal mass accumulation within the tissue layer of Porites from Australasian coral reefs and laboratory culturing experiments. The results show that the sensitivity of the Sr/Ca and d18O thermometers in Porites will be suppressed, variable, and dependent on the relationship between skeletal growth rate and mass accumulation within the tissue layer. Our findings help explain why d18O-SST sensitivities for Porites range from -0.08 per mil/°C to -0.22 per mil/°C and are always less than the value of -0.23 per mil/°C established for biogenic aragonite. Based on this observation, we recalibrated the coral Sr/Ca thermometer to determine a revised sensitivity of -0.084 mmol/mol/°C. After rescaling, most of the published Sr/Ca-SST estimates for the Indo-Pacific region for the last ~14,000 years (-7°C to +2°C relative to modern) fall within the 95% confidence envelope of the foraminiferal Mg/Ca-SST records. We conclude that two types of calibration scales are required for coral paleothermometry; an attenuated Porites-specific thermometer sensitivity for studies of seasonal to interannual change in SST and, importantly, the rescaled -0.084 mmol/mol/°C Sr/Ca sensitivity for studies of 20th-century trends and millennial-scale changes in mean SST. The calibration-scaling concept will apply to the development of transfer functions for all geochemical tracers in corals.
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Esta investigación surge a raíz de la experiencia profesional del autor, maestro especialista de Educación Física en el C.E.I.P. “Alhambra” de Madrid, cuando de manera progresiva, aprecia que el tenis de mesa puede ser un deporte muy interesante de desarrollar en las sesiones de Educación Física y de promover dentro de los tiempos de recreo. El autor cree que este deporte desarrolla una serie de objetivos motrices, afectivos, cognitivos y sociales que pueden contribuir a la adquisición de las competencias básicas y al desarrollo integral de los alumnos. Es entonces cuando recibe formación sobre el deporte de tenis de mesa y busca los medios necesarios de financiación para que se dote al centro del material necesario. Así la Junta municipal del distrito de Fuencarral-El Pardo instala en el patio del colegio tres mesas de exterior y, con los recursos del colegio y la ayuda de la Asociación de padres y madres (AMPA), se consiguen cinco mesas de interior plegables y todo el material necesario (redes, raquetas, pelotas, etc.). Tras introducir este deporte desde 3º a 6º de Educación Primaria promueve un campeonato en el colegio cuyo índice de participación ronda el 90% del alumnado, estos resultados crean al autor ciertas incertidumbres que son la motivación y punto de partida para realizar esta investigación que analice si la práctica del tenis de mesa puede resultar idónea en la etapa de Educación Primaria. Introducción La legislación actual en materia de educación, Ley Orgánica 2/2006, de 3 de mayo, de Educación (LOE) modificada por la Ley Orgánica 8/2013, de 9 de diciembre, para la mejora de la calidad educativa. (LOMCE), otorga una gran relevancia al deporte en general. "El deporte es una actividad saludable, divertida y formativa que puede tener profundos beneficios no sólo para su salud y su bienestar sino también para el desarrollo personal integral físico, psicológico y psicosocial del niño, además de sobre su desarrollo deportivo" (Pradas, 2009, p. 151), es pues, un momento idóneo para analizar qué deportes se practican en los colegios o por qué se practican unos más que otros. "El tenis de mesa además de ser un deporte para todos, se presenta como un juego atractivo, en donde su práctica resulta muy divertida a cualquier edad, tanto para niños como para adultos, principalmente porque presenta unas reglas de juego simples, no encerrando peligro alguno para la integridad física de sus practicantes durante su juego" (Pradas, 2009, p. 83). Es un deporte que "está abierto a todos, sin distinción de edad o sexo, tanto como deporte de alto nivel como de práctica familiar o social" (Gatien, 1993, p. 16). No obstante, "son escasas las obras sobre tenis de mesa. Pocos libros, tanto de divulgación como de reflexión sobre el tenis de mesa, adornan los estantes de las librerías y las bibliotecas" (Erb, 1999, p.14) y añade “así pues, el medio escolar padece de falta de obras explicativas y pedagógicas referidas a este tema" (Erb, 1999, p.14 ) En particular, se pretenden conseguir cinco objetivos divididos en tres categorías (el centro, el profesorado y el deporte. • A nivel de Centro: - Conocer el porcentaje de colegios que disponen de espacios y materiales adecuados para la práctica del tenis de mesa, así como identificar, de las distintas Direcciones de Área Territoriales (DAT), cuál tiene los colegios mejor dotados tanto en instalaciones como en materiales para desarrollar programas de promoción del tenis de mesa. - Averiguar las posibles causas por las que el tenis de mesa no se practica tanto como otros deportes, analizando los impedimentos que limitan la implantación del tenis de mesa como un deporte habitual en los centros de Educación Primaria. Analizar la opinión del profesorado en cuanto a los materiales y las instalaciones necesarios para el tenis de mesa. • A nivel de profesorado: - Analizar el nivel de conocimiento que tienen los profesionales que imparten la asignatura de Educación Física sobre el tenis de mesa, así como sus necesidades para incluir unidades didácticas de tenis de mesa en sus programaciones didácticas. - Conocer el perfil de profesor ideal que recomienda la utilización del tenis de mesa y averiguar el interés del profesorado por recibir formación específica del tenis de mesa. • A nivel de deporte: - Analizar la opinión de los profesionales sobre la idoneidad del tenis de mesa en la Educación Primaria atendiendo a los objetivos que persigue, a las competencias que desarrolla, a los contenidos, criterios de evaluación y estándares de aprendizaje que se pueden trabajar y a las lesiones que se producen. Metodología La investigación se caracterizó por utilizar una metodología inductiva, al surgir de la experiencia profesional del autor, también fue transversal al analizar la realidad en un momento concreto y de tipo cuantitativa. La población objeto de estudio fue la totalidad de los colegios públicos de la Comunidad de Madrid, siendo los profesores de Educación Física los encargados de facilitar los datos solicitados. Estos datos se obtuvieron utilizando como instrumento de toma de datos el cuestionario auto administrado con preguntas cerradas de opción múltiple previamente validado por un panel de 5 expertos. Las variables indirectas fueron: el género del profesorado, la edad del profesorado, la experiencia profesional y el tipo de destino. El proceso de la toma de datos supuso un lapso de tiempo de 3 meses, desde mayo de 2015 hasta julio de 2015, en este tiempo hubo dos fases de recogida de datos, una online a través del correo electrónico institucional de los colegios públicos de la Comunidad de Madrid y otra “in situ” con cuestionarios de lápiz y papel. En cuanto a los datos que se obtuvieron, sobre una población de 798 colegios, se consiguió una muestra de 276, esto supuso una tasa de respuesta del 34,59%, asumiendo la situación más desfavorable posible (p=q) y un nivel de confianza del 95%, para el total de los 276 cuestionarios cumplimentados, el error máximo fue del ±4,78%. Resultados En cuanto a los resultados obtenidos, se establecieron de acuerdo a tres dimensiones: A nivel de Centro, a nivel de Profesorado y a nivel del Deporte y pretendieron averiguar si se alcanzaron los cinco objetivos planteados. Tras el análisis de los resultados, se apreció que los colegios públicos de la Comunidad de Madrid disponían de las suficientes instalaciones para el tenis de mesa, en cambio, faltaban materiales específicos y formación por parte del profesorado, así como recursos didácticos y un programa de promoción del tenis de mesa. Se apreció un manifiesto interés por parte del profesorado en recibir formación específica de tenis de mesa pues la mayoría recomendaba la utilización del tenis de mesa dentro de la asignatura de Educación Física en Educación Primaria. Por último, los resultados mostraron la cantidad de objetivos motrices, afectivos, cognitivos y sociales que desarrolla el tenis de mesa así como su contribución a la adquisición de las competencias básicas y al objetivo “k” de la Educación Primaria, que indica “Valorar la higiene y la salud, conocer y respetar el cuerpo humano, y utilizar la Educación Física y el deporte como medios para favorecer el desarrollo personal y social”, además, se mostró el bajo índice de lesiones que provoca. Discusión y conclusiones El tenis de mesa es un deporte idóneo para ser practicado y enseñado en la asignatura de Educación Física en la etapa de Educación Primaria debido a la gran cantidad de contenidos que son susceptibles de ser trabajados a través de este deporte y debido a la gran cantidad de valores, individuales y sociales que se pueden fomentar con la práctica del tenis de mesa. Las causas de que hasta ahora, el tenis de mesa no sea un deporte practicado de forma habitual en los colegios públicos de la Comunidad de Madrid a pesar de trabajar muchos contenidos específicos de la asignatura de Educación Física puede deberse a factores externos al deporte del tenis de mesa y susceptibles de ser solucionados con una adecuada inversión en materiales específicos, formación del profesorado y recursos didácticos. Si se dota a los centros de los materiales y recursos didácticos necesarios y dando formación al profesorado, éste introduciría unidades didácticas de tenis de mesa dentro de sus programaciones anuales. La federación española y madrileña de tenis de mesa, deberían desarrollar un programa de promoción dotando de materiales y recursos a los centros, tal y como lo han hecho otras federaciones como la de voleibol, bádminton o de baloncesto, entre otras. ABSTRACT This research arises from the professional experience of the author, specialized teacher of physical education in the CEIP "Alhambra" in Madrid, where progressively, appreciates that table tennis can be a very interesting sport to develop in physical education sessions and promote within the playtimes. The author believes that this sport develops a range of motor, affective, cognitive and social objectives that can contribute to the acquisition of basic skills and the integral development of students. It is then when receives training on the sport of table tennis and seeks ways of funding in order to outfit the center with necessary equipment. The Municipal District of Fuencarral-El Pardo installed three outdoor tables in the schoolyard and with the resources of the school and the support of the Association of Parents (AMPA), five indoor folding tables are achieved as well as all the necessary material (nets, rackets, balls, etc.). After introduce the sport from 3rd to 6th grade of primary education, promotes a championship in the school where the participation rate is around 90% of students, these results create the uncertainties to the author that are the motivation and starting point for this research to analyze whether the practice of table tennis can be ideal at the stage of primary education. Introduction The current legislation on education, Organic Law 2/2006 of 3 May, on Education (LOE) as amended by Organic Law 8/2013, of December 9, to improve educational quality (LOMCE), attaches great importance to the sport in general, "Sport is a healthy, funny and educational activity that can have great benefits not only for their health and well-being but also for the physical, psychological and psychosocial comprehensive personal child development besides on their sports development "(Pradas, 2009, p. 151), is therefore an ideal moment to analyze which sports are practiced in schools or why are practiced some more than others. "The table tennis as well as being a sport for everyone, is presented as an attractive game, where its practice is funny at any age, both children and adults, mainly because it has simple game rules, not enclosing danger for the physical integrity of its practitioners during their game" (Pradas, 2009, p. 83). It is a sport that is "open to all, regardless of age or sex, as high-level sport, as family or social practice" (Gatien, 1993, p. 16). However, "there are few books on table tennis. Few books, both reflexion or popularization about table tennis, adorn the shelves of bookstores and libraries." (Erb, 1999, p.14) and add "So, the school environment suffers from lack of explanatory and educational work related to this issue." (Erb, 1999, p.14) In particular, it is intended to achieve the following objectives within the Community of Madrid: • To determine the percentage of schools that have spaces and materials suitable for practicing table tennis and identify, from the different Directorates of Land Area (DAT), which has the best equipped schools in both facilities and materials to develop programs to promote table tennis. • Find out the possible causes that explained why table tennis is not practiced as much as other sports, analyzing impediments that limit the implementation of table tennis as a regular sport in primary schools. Analyze the opinion of teachers in terms of materials and facilities needed for table tennis. • Analyze the level of knowledge about table tennis among professionals who teach the subject of Physical Education and their needs to include teaching units about table tennis in their teaching programs. • Knowing the profile of the ideal teacher who recommends the use of table tennis and figure out the interest of teachers to receive specific training of table tennis. • Analyze the professional opinion on the suitability of table tennis in Primary Education taking into account the objectives pursued, to develop the skills, content, evaluation criteria and learning standards that can work and injuries involved. Methodology The investigation was characterized by using an inductive methodology, arising from the professional experience of the author, was also transverse to analyze reality in a particular time and quantitative type. The population under study were all the state schools in Madrid region, being the physical education teachers responsible for providing the requested data. These data were obtained using as data collection instrument a self-administered questionnaire with multiple choice questions, because it facilitates the analysis thereof. In terms of obtained data, on a population of 798 schools, a sample of 276 was achieved, this represented a response rate of 34.59%, assuming the worst case scenario (p = q) and a level 95% confidence for the total of the 276 completed questionnaires, the maximum error was ± 4.78%. Results In terms of the results, they were set according to three dimensions: center level, professorate level and Sport level and trying to find out whether the five objectives were achieved. After analyzing the results, it was found that schools possessed sufficient facilities for table tennis, however, lacked specific materials and training by teachers, as well as teaching resources and a program to promote table tennis. A clear interest was noticed by teachers in order to receive specific training in table tennis since most recommended the use of table tennis in the subject of physical education in primary education. Finally, the results proved the number of motor, affective, cognitive and social objectives developed by table tennis and its contribution to the acquisition of basic skills and the objective "k" of primary education, in addition to the low rate of injury it causes. Discussion and conclusions Table tennis is an ideal sport to be practiced and taught in the subject of Physical Education in Primary Education due to the large amount of content that are likely to be worked through this sport and due to the large number of individual and social values that can foster the practice of table tennis. The causes of that so far, table tennis is not a sport practiced regularly in schools despite working many specific contents of the subject of Physical Education may be due to factors outside the sport of table tennis and subject to solved with adequate investment in specific materials, teacher training and educational resources. By endowing the centers with the necessary teaching materials and resources and providing training to teachers, they would introduce teaching units of table tennis within their annual programs. Madrid and the Spanish Federation of table tennis should develop a promotional program by endowing materials and resources to the centers, as did other federations such as badminton and basketball, among others.
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We have analyzed inorganic and organic carbons and determined the isotopic composition of both sedimentary organic carbon and inorganic carbon in carbonates contained in sediments recovered from Holes 434, 434A, 434B, 435, and 435A in the landward slope of Japan and from Hole 436 in the oceanic slope of the Japan Trench. Both inorganic and organic carbons were assayed at the P. P. Shirshov Institute of Oceanology, in the same sample, using the Knopp technique and measuring evolved CO2 gravimetrically. Each sample was analyzed twice in parallel. Measurements were of a ±0.05 per cent accuracy and a probability level of 0.95. Carbon isotopic analysis was carried out on a MI-1305 mass spectrometer at the I. M. Gubkin Institute of Petrochemical and Gas Industry and the results presented as dC13 values related to the PDB standard. The procedure for preparing samples for organic carbon isotopic analysis involved (1) drying damp sediments at 60°C; (2) treating samples, while heating, with 10 N HCl to remove carbonate carbon; and (3) evaporating surplus HCl at 60°C. The organic substance was turned to CO2 by oxidizing it in an oxygen atmosphere. To prepare samples for inorganic carbon isotopic analysis we decomposed the carbonates with orthophosphoric acid and refined the gas evolved. The dC13 measurements, including a full cycle of sample preparation, were of a ±0.5 per cent accuracy and a probability level of 0.95.
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Thesis (Master's)--University of Washington, 2016-06
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Background: Reliability or validity studies are important for the evaluation of measurement error in dietary assessment methods. An approach to validation known as the method of triads uses triangulation techniques to calculate the validity coefficient of a food-frequency questionnaire (FFQ). Objective: To assess the validity of an FFQ estimates of carotenoid and vitamin E intake against serum biomarker measurements and weighed food records (WFRs), by applying the method of triads. Design: The study population was a sub-sample of adult participants in a randomised controlled trial of beta-carotene and sunscreen in the prevention of skin cancer. Dietary intake was assessed by a self-administered FFQ and a WFR. Nonfasting blood samples were collected and plasma analysed for five carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, lycopene) and vitamin E. Correlation coefficients were calculated between each of the dietary methods and the validity coefficient was calculated using the method of triads. The 95% confidence intervals for the validity coefficients were estimated using bootstrap sampling. Results: The validity coefficients of the FFQ were highest for alpha-carotene (0.85) and lycopene (0.62), followed by beta- carotene (0.55) and total carotenoids (0.55), while the lowest validity coefficient was for lutein (0.19). The method of triads could not be used for b- cryptoxanthin and vitamin E, as one of the three underlying correlations was negative. Conclusions: Results were similar to other studies of validity using biomarkers and the method of triads. For many dietary factors, the upper limit of the validity coefficients was less than 0.5 and therefore only strong relationships between dietary exposure and disease will be detected.
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Background Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. Objectives To assess the effects of viscosupplementation in the treatment of OA of the knee. The products were hyaluronan and hylan derivatives (Adant, Arthrum H, Artz (Artzal, Supartz), BioHy (Arthrease, Euflexxa, Nuflexxa), Durolane, Fermathron, Go-On, Hyalgan, Hylan G-F 20 (Synvisc Hylan G-F 20), Hyruan, NRD-101 (Suvenyl), Orthovisc, Ostenil, Replasyn, SLM-10, Suplasyn, Synject and Zeel compositum). Search strategy MEDLINE (up to January (week 1) 2006 for update), EMBASE, PREMEDLINE, Current Contents up to July 2003, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched. Specialised journals and reference lists of identified randomised controlled trials (RCTs) and pertinent review articles up to December 2005 were handsearched. Selection criteria RCTs of viscosupplementation for the treatment of people with a diagnosis of OA of the knee were eligible. Single and double-blinded studies, placebo-based and comparative studies were eligible. At least one of the four OMERACT III core set outcome measures had to be reported (Bellamy 1997). Data collection and analysis Each trial was assessed independently by two reviewers for its methodological quality using a validated tool. All data were extracted by one reviewer and verified by a second reviewer. Continuous outcome measures were analysed as weighted mean differences (WMD) with 95% confidence intervals (CI). However, where different scales were used to measure the same outcome, standardized mean differences (SMD) were used. Dichotomous outcomes were analyzed by relative risk (RR). Main results Seventy-six trials with a median quality score of 3 (range 1 to 5) were identified. Follow-up periods varied between day of last injection and eighteen months. Forty trials included comparisons of hyaluronan/hylan and placebo (saline or arthrocentesis), ten trials included comparisons of intra-articular (IA) corticosteroids, six trials included comparisons of nonsteroidal anti-inflammatory drugs (NSAIDs), three trials included comparisons of physical therapy, two trials included comparisons of exercise, two trials included comparisons of arthroscopy, two trials included comparisons of conventional treatment, and fifteen trials included comparisons of other hyaluronans/hylan. The pooled analyses of the effects of viscosupplements against 'placebo' controls generally supported the efficacy of this class of intervention. In these same analyses, differential efficacy effects were observed for different products on different variables and at different timepoints. Of note is the 5 to 13 week post injection period which showed a percent improvement from baseline of 28 to 54% for pain and 9 to 32% for function. In general, comparable efficacy was noted against NSAIDs and longer-term benefits were noted in comparisons against IA corticosteroids. In general, few adverse events were reported in the hyaluronan/hylan trials included in these analyses. Authors' conclusions Based on the aforementioned analyses, viscosupplementation is an effective treatment for OA of the knee with beneficial effects: on pain, function and patient global assessment; and at different post injection periods but especially at the 5 to 13 week post injection period. It is of note that the magnitude of the clinical effect, as expressed by the WMD and standardised mean difference (SMD) from the RevMan 4.2 output, is different for different products, comparisons, timepoints, variables and trial designs. However, there are few randomised head-to-head comparisons of different viscosupplements and readers should be cautious, therefore, in drawing conclusions regarding the relative value of different products. The clinical effect for some products, against placebo, on some variables at some timepoints is in the moderate to large effect-size range. Readers should refer to relevant tables to review specific detail given the heterogeneity in effects across the product class and some discrepancies observed between the RevMan 4.2 analyses and the original publications. Overall, the analyses performed are positive for the HA class and particularly positive for some products with respect to certain variables and timepoints, such as pain on weight bearing at 5 to 13 weeks postinjection. In general, sample-size restrictions preclude any definitive comment on the safety of the HA class of products; however, within the constraints of the trial designs employed no major safety issues were detected. In some analyses viscosupplements were comparable in efficacy to systemic forms of active intervention, with more local reactions but fewer systemic adverse events. In other analyses HA products had more prolonged effects than IA corticosteroids. Overall, the aforementioned analyses support the use of the HA class of products in the treatment of knee OA.
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Objective: The aims of this study were to estimate average yearly weight gain in midage women and to identify the determinants of weight gain and gaining weight at double the average rate. Research Methods and Procedures: The study sample comprised 8071 participants (45 to 55 years old) in the Australian Longitudinal Study on Women's Health who completed mailed surveys in 1996, 1998, and 2001. Results: On average, the women gained almost 0.5 kg per year [average 2.42 kg (95% confidence interval, 2.29 to 2.54) over 5 years]. In multivariate analyses, variables associated with energy balance (physical activity, sitting time, and energy intake), as well as quitting smoking, menopause/hysterectomy, and baseline BMI category were significantly associated with weight gain, but other behavioral and demographic characteristics were not. After adjustment for all of the other biological and behavioral variables, the odds of gaining weight at about twice the average rate (> 5 kg over 5 years) were highest for women who quit smoking (odds ratio = 2.94; 95% confidence interval, 2.17, 3.96). There were also independent relationships between the odds of gaining > 5 kg and lower levels of habitual physical activity, more time spent sitting, energy intake (but only in women with BMI > 25 at baseline), menopause transition, and hysterectomy. Discussion: The average weight gain equates with an energy imbalance of only about 10 kcal or 40 kJ per day, which suggests that small sustained changes in the modifiable behavioral variables could prevent further weight gain.
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Objective: We hypothesized that the hormonal changes of adolescence influence ovarian cancer risk particularly in younger women. We investigated this possibility by examining the relationship between ovarian cancer and adult height and age at menarche as both factors reflect pubertal hormonal levels. Methods: Participants were a population-based sample of women with incident ovarian cancer (n = 794) and control women randomly selected from the Australian Electoral Roll (n = 855). The women provided comprehensive reproductive and lifestyle data during a standard interview. Results: Although neither height nor age at menarche was significantly related to the risk of ovarian cancer overall, increasing height was associated with increasing risk of the subgroup of mucinous borderline ovarian cancer (odds ratio, 5.3; 95% confidence interval, 1.5-19.1 for women 175 cm compared with women < 160 cm, P-trend = 0.02). Similarly, later age at menarche was associated with increasing risk of mucinous borderline cancers (odds ratio, 3.8; 95% confidence interval, 1.3-11.4 for those with age at menarche >= 44 years compared with those < 12 years, P-trend = 0.003). Women with mucinous borderline cancers were significantly younger than the women diagnosed with invasive cancers (mean 44 versus 57 years; P < 0.0001). Conclusions: Development of mucinous borderline ovarian cancers, predominantly diagnosed in women ages under 50 years, seems to be associated with age at menarche and attained adult height. These results are consistent with our original hypothesis that pubertal levels of reproductive hormones and insulin-like growth factor-I influence ovarian cancer risk in younger women.
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The aim of this study was to quantify movements of Super 12 rugby players in competition because information on elite rugby players' movements is unavailable. Players were categorized into forwards [front (n = 16) and back row (n = 15)] and backs [inside (n = 9) and outside backs (n = 7)] and their movements analysed by video-based time motion analysis. Movements were classified as rest (standing, walking and jogging) and work (striding, sprinting, static exertion, jumping, lifting or tackling). The total time, number and duration of individual activities were assessed, with differences between groups evaluated using independent sample t-tests (unequal variances), while differences between halves were assessed with paired sample t-tests. Forwards had 7:47 min:s (95% confidence limits: 6:39 to 8:55 min:s, P
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Aims Previous isobolographic analysis revealed that coadministration of morphine and oxycodone produces synergistic antinociception in laboratory rodents. As both opioids can produce ventilatory depression, this study was designed to determine whether their ventilatory effects were synergistic when coadministered to healthy human subjects. Methods A placebo-controlled, randomized, crossover study was performed in 12 male volunteers. Ventilatory responses to hypoxaemia and hypercapnia were determined from 1-h intravenous infusions of saline ('placebo'), 15 mg morphine sulphate (M), 15 mg oxycodone hydrochloride (O), and their combination in the dose ratios of 1 : 2, 1 : 1, 2 : 1. Drug and metabolite concentrations in serial peripheral venous blood samples were measured by high-performance liquid chromatography-MS/MS. Results 'Placebo' treatment was without significant ventilatory effects. There were no systematic differences between active drug treatments on either the slopes or intercepts of the hypoxaemic and hypercapnia ventilation responses. During drug treatment, the mean minute ventilation at PETCO2 = 55 mmHg (V-E55) decreased to 74% of the subjects' before treatment values (95% confidence interval 62, 87), 68% (57, 80), 69% (59, 79), 68% (63, 73), and 61% (52, 69) for M15, M10/O5, M7.5/O7.5, M5/O10 and O15, respectively. Recovery was more prolonged with increasing oxycodone doses, corresponding to its greater potency and lower clearance compared with morphine. Conclusions Although adverse ventilatory effects of these drugs were found as expected, no unexpected or disproportionate effects of any of the morphine and oxycodone treatments were found that might impede their use in combination for pain management.
