Los sedimentos de la plataforma continental balear

El análisis sedimentológico de distintos sectores de la plataforma continental balear (Bahia de Campos, Sur de Menorca y Canal de Menorca) ha puesto de manifiesto la existencia de siete grupos de facies: A) algales, B) de bivalvos, C) de gasterpodos, D) bioclsticas, E) mixtas, F) de fragmentos liticos y G) cementadas (costras algales y calcarenitas). La distribución de estas facies sedimentarias guarda una estrecha relación con la profundidad, excepto en el Sur de Menorca, y con las comunidades bentónicas que se desarrollan en la plataforma continental. Las facies que recubren actualmente la plataforma balear se depositaron durante la fase del ascenso del nivel del mar de la transgresión Versiliense.

El Dr. Lluís Via Boada, una vida fecunda

El Dr. Lluís Via Boada, nació en Vilafranca del Penedes en octubre de 1910, y empezó sus estudios eclesiásticos en el Seminario de Barcelona en setiembre de 1925.

Sobre la edad oligocénica inferior del yacimiento de Santpedor (Cuenca del Ebro, provincia de Barcelona)

Un muestreo intensivo del clasico yacimiento de mamíferos fósles de Santpedor ha dado como resultado la presencia de Theridomys aff. aquatilis, Gliravus aff. priscus, Eucricetodon atavus y Pseudoltinomys gaillardi. Esta asociacin permite atribuir 1os niveles del yacimiento al Oligoceno inferior mas bajo (nivel de Hoogbutsel)

El Complejo Turbidítico del Carbonífero del Priorat (Tarragona)

Relaciones entre las asociaciones de facies de las tres unidades litoestratigráficas del complejo turbidítico y su asimilación a unidades deposicionales dentro de modelos de sedimentación submarina.

Presencia de Caliche Fósil en el Buntsandstein del valle del Congost (Provincia de Barcelona)

Se señala la presencia de caliche fósil en el Triásico inferior y el cual es interpretado como caliche inicialmente maduro producido en cortas exposiciones subáreas en condiciones semiáridas. Se deducen das tipos de ambientes de acuerdo con los dos modelos $e secuencias litolgicas en las que se encuentra el caliche: partes distale de glacis de acumulación y 'playas', y diques y charcas en una llanura aluvial meandriforme.

Vitellogenin B2 gene in Xenopus laevis: isolation, in vitro transcription and relation to other vitellogenin genes.

The isolation of the four Xenopus laevis vitellogenin genes has been completed by the purification from a DNA library of the B2 gene together with its flanking sequences. The overlapping DNA fragments analyzed cover 34 kilobases. The B2 gene which has a length of 17.5 kilobases was characterized by heteroduplex and R-loop mapping in the electron microscope and by in vitro transcription in a HeLa whole-cell extract. Its structural organization is compared with that of the closely related B1 gene. The mRNA-coding sequence of about 6 kilobases is interrupted 34 times in the B1 gene and 33 times in the B2 gene. Sequence homology between the two genes was not only found in exons. In addition, 54% of the intron sequences as well as 63% and 48.5% respectively of the 5' and 3' flanking sequences, show enough homology to form stable duplexes. These findings are compared with earlier results obtained with the two other closely related members of the vitellogenin gene family, the A1 and the A2 genes.

PAR2 Promotes Vaccine-Induced Protection Against Helicobacter Infection in Mice.

BACKGROUND & AIMS: Protective immunization limits Helicobacter infection of mice by undetermined mechanisms. Protease-activated receptor 2 (PAR2) signaling is believed to regulate immune and inflammatory responses. We investigated the role of PAR2 in vaccine-induced immunity against Helicobacter infection. METHODS: Immune responses against Helicobacter infection were compared between vaccinated PAR2(-/-) and wild-type (WT) mice. Bacterial persistence, gastric pathology, and inflammatory and cellular responses were assessed using the rapid urease test (RUT), histologic analyses, quantitative polymerase chain reaction, and flow cytometry, respectively. RESULTS: Following vaccination, PAR2(-/-) mice did not have reductions in Helicobacter felis infection (RUT values were 0.01 ± 0.01 for WT mice and 0.11 ± 0.13 for PAR2(-/-) mice; P < .05). The vaccinated PAR2(-/-) mice had reduced inflammation-induced stomach tissue damage (tissue damage scores were 8.83 ± 1.47 for WT mice and 4.86 ± 1.35 for PAR2(-/-) mice; P < .002) and reduced T-helper (Th)17 responses, based on reduced urease-induced interleukin (IL)-17 secretion by stomach mononuclear cells (5182 ± 1265 pg/mL for WT mice and 350 ± 436 pg/mL for PAR2(-/-) mice; P < .03) and reduced recruitment of CD4(+) IL-17(+) T cells into the gastric mucosa of PAR2(-/-) mice following bacterial challenge (3.7% ± 1.5% for WT mice and 2.6% ± 1.1% for PAR2(-/-) mice; P < .05). In vitro, H felis-stimulated dendritic cells (DCs) from WT mice induced greater secretion of IL-17 by ovalbumin-stimulated OT-II transgenic CD4(+) T cells compared with DCs from PAR2(-/-) mice (4298 ± 347 and 3230 ± 779; P < .04), indicating that PAR2(-/-) DCs are impaired in priming of Th17 cells. Adoptive transfer of PAR2(+/+) DCs into vaccinated PAR2(-/-) mice increased vaccine-induced protection (RUT values were 0.11 ± 0.10 and 0.26 ± 0.15 for injected and noninjected mice, respectively; P < .03). CONCLUSIONS: PAR2 activates DCs to mediate vaccine-induced protection against Helicobacter infection in mice.

Rethinking ovarian cancer: recommendations for improving outcomes.

There have been major advances in our understanding of the cellular and molecular biology of the human malignancies that are collectively referred to as ovarian cancer. At a recent Helene Harris Memorial Trust meeting, an international group of researchers considered actions that should be taken to improve the outcome for women with ovarian cancer. Nine major recommendations are outlined in this Opinion article.

Counter-ion effect on surfactant-DNA gel particles as controlled DNA delivery systems

The ability to entrap drugs within vehicles and subsequently release them has led to new treatments for a number of diseases. Based on an associative phase separation and interfacial diffusion approach, we developed a way to prepare DNA gel particles without adding any kind of cross-linker or organic solvent. Among the various agents studied, cationic surfactants offered particularly efficient control for encapsulation and DNA release from these DNA gel particles. The driving force for this strong association is the electrostatic interaction between the two components, as induced by the entropic increase due to the release of the respective counter-ions. However, little is known about the influence of the respective counter-ions on this surfactant-DNA interaction. Here we examined the effect of different counter-ions on the formation and properties of the DNA gel particles by mixing DNA (either single- (ssDNA) or double-stranded (dsDNA)) with the single chain surfactant dodecyltrimethylammonium (DTA). In particular, we used as counter-ions of this surfactant the hydrogen sulfate and trifluoromethane sulfonate anions and the two halides, chloride and bromide. Effects on the morphology of the particles obtained, the encapsulation of DNA and its release, as well as the haemocompatibility of these particles, are presented, using the counter-ion structure and the DNA conformation as controlling parameters. Analysis of the data indicates that the degree of counter-ion dissociation from the surfactant micelles and the polar/hydrophobic character of the counter-ion are important parameters in the final properties of the particles. The stronger interaction with amphiphiles for ssDNA than for dsDNA suggests the important role of hydrophobic interactions in DNA.

pH Sensitive surfactants from lysine: assessment of their cytotoxicity and environmental behavior

The toxicity and environmental behavior of new pH-sensitive surfactants from lysine are presented. Three different chemical structures are studied: surfactants with one amino acid and one alkyl chain, surfactants with two amino acids on the polar head and one alkyl chain, and gemini surfactants. The pH sensitivity of these compounds can be tuned by modifying their chemical structures. Cytotoxicity has been evaluated using erythrocytes and fibroblast cells. The toxic effects against these cells depend on the hydrophobicity of the molecules as well as their cationic charge density. The effect of hydrophobicity and cationic charge density on toxicity is different for each type of cells. For erythrocytes, the toxicity increases as hydrophobicity and charge density increases. Nevertheless, for fibroblasts cationic charge density affects cytotoxicity in the opposite way: the higher charge density, the lower the toxicity. The effect of the pH on hemolysis has been evaluated in detail. The aquatic toxicity was established using Daphnia magna. All surfactants yielded EC50 values considerably higher than that reported for cationic surfactants based on quaternary ammonium groups. Finally, their biodegradability was evaluated using the CO2 headspace test (ISO 14593). These lysine derivatives showed high levels of biodegradation under aerobic conditions and can be classified as"readily biodegradable compounds".

Els recursos digitals com a suport a l’aprenentatge i la docència a la UB.

Comunicació presentada a "Seminario Library Connect Barcelona 2008". Universitat de Barcelona. Facultat de Biblioteconomia i Documentació, 21 d’octubre de 2008

Repositorios digitales en medicina: Fortalezas, oportunidades, retos y amenazas

Comunicació presentada a "XII Jornadas de Información y Documentación en Ciencias de la Salud". Saragossa, 24, 25 i 26 d'octubre de 2007

Procedimientos de gestión: Tarifas, facturación e IVA

Ponència presentada a "I Jornada Rebiun de Préstamo Interbibliotecario", Campus de Toledo de la Universidad de Castilla-La Mancha, 27 de marzo de 2009