Immunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: Correlation of prognostic factors and clinical outcome

E-cadherin is a cell-cell adhesion molecule and low e-cadherin expression is related to invasiveness and may indicate a bad prognosis in mammary neoplasms. The expression of cell proliferation markers PCNA and especially Ki-67, has also proved to have a strong prognostic value in this tumor class. The expression of these markers was related to the clinical-pathological characteristics of 73 surgically removed mammary tumors in female dogs by immunohistochemistry. There was no statistical correlation between these markers and death by neoplasm, survival time and disease-free interval. However, the loss of e-cadherin expression and marked Ki-67 expression (p=0.016) were considered statistically significant for the diagnosis (p=0.032). When evaluated as independent factors, there was evidence of the relationship between the loss of e-cadherin expression and high PCNA expression with changes in the body status (divided into obese, normal and cachectic) of female dogs (p=0.030); there was also evidence of the relationship between pseudopregnancy and e-cadherin alone (p=0.021) and for ulceration and PCNA alone (p=0.035). The significant correlation between the markers expression and these well known prognostic factors used individually or in combination suggests their prognostic value in canine mammary tumors.

Voltage regulator modeling for the three-phase power flow in distribution networks

In this paper a three-phase power flow for electrical distribution systems considering different models of voltage regulators is presented. A voltage regulator (VR) is an equipment that maintains the voltage level in a predefined value in a distribution line in spite of the load variations within its nominal power. Three different types of connections are analyzed: 1) wye-connected regulators, 2) open delta-connected regulators and 3) closed delta-connected regulators. To calculate the power flow, the three-phase backward/forward sweep algorithm is used. The methodology is tested on the IEEE 34 bus distribution system. ©2008 IEEE.

Theoretical and experimental evaluation of the influence of the length of drill rods in the SPT-T test

The influence of soil drill rod length on the N value in the SPT-T test has been studied extensively by Mello (1971), Schmertmann & Palacios (1979), Odebrecht et al. (2002) and Cavalcante (2002). This paper presents an analysis of the Standard Penetration Test supplemented with torque measurement (SPT-T). A theoretical study of the resistance of the rod material to torsion and bending indicated that the shear stress caused by the rod self-weight represents less than 1% of that caused by the torsional moment. An experimental study with electric torquemeters attached to a horizontal rod system, as well as two field tests in the vertical direction, were also carried out to compare and substantiate the results. The purpose of these tests was to analyze changes along the length of the rod in response to successive increments at 1-meter intervals. Torque measurements were taken at each increment of the length to ascertain the accuracy of the theoretical data. The difference between the applied torque and the measured torque at the end of rod system was lower than the minimum scale of mechanical torquemeters used in practice.

Maximal clenching effort influence on the electromyographic activity of the trapezius muscle in healthy subjects

Alteration of the occlusion and the position of the jaw can affect the muscles of the neck, due to a relationship between the masticatory and cervical systems. Thus, the objective of this study was to verify whether the bite in maximal clenching effort, in centric occlusion, in individuals with clinically normal occlusion, and without a history of dysfunction in the masticatory system, influences the electromyographic activity of the upper trapezius muscle. A total of 19 normal individuals participated in the study, 14 of which were women (average age of 25.4 ± 4.14 years), and 5 were men (average age of 24.11 ± 3.28 years). The root mean square (RMS) amplitude and median frequency (MF) of the upper trapezium muscle with 40% and 60% of maximal voluntary contraction were analyzed under pre- and post-maximal clenching effort conditions in centric occlusion. The electromyographic signal was collected with a sampling frequency of 2. kHz and the value in RMS was obtained by a moving window of 200. ms. The paired Student's t-test was used to compare RMS amplitude and MF under pre- and post-maximal clenching effort conditions. The level of significance for each comparison was set to p<0.05. This study concluded that in individuals without a history of dysfunction of the masticatory system, maximum clenching effort in centric occlusion does not alter the electromyographic signal of the upper trapezius. © 2009 Elsevier Ltd.

ProGriD: The transformation package for the adoption of SIRGAS2000 in Brazil

Brazil adopted SIRGAS2000 in 2005. This adoption called for the provision of the relationships between SIRGAS2000 and the previous reference frames used for positioning, mapping and GIS, namely, the Córrego Alegre (CA) and the South American Datum of 1969 (SAD 69). Two programs were designed for this purpose. The first one, TCGeo, provided the relationships based on three-translation Similarity Transformation parameters. TCGeo was replaced in December 2008, by ProGriD. ProGriD offers, besides the same similarity transformation as TCGeo, a set of transformations based on modelling the distortions of the networks used in the various realizations of CA and SAD 69. The distortion models are represented by a grid in which each node contains a transformation value in terms of difference in latitude and in longitude. The grid follows the same specifications of the NTv2 grid, which has been used in other countries, such as Canada, USA and Australia. This paper presents ProGriD and its main functionalities and capabilities. ©Springer-Verlag Berlin Heidelberg 2012.

Estrogen receptors alpha and beta in male and female gerbil prostates

The Mongolian gerbil (Meriones unguiculatus, Gerbilinae: Muridae) is useful for prostate studies, because both males and females spontaneously develop prostatic disorders with age. Estrogens regulate prostate homeostasis via two estrogen receptors, ER alpha (ESR1) and ER beta (ESR2), but the cellular distribution and regulation of these receptors in the gerbil prostate has not been described. Both receptors were localized by immunohistochemistry in the ventral prostate of intact male and female gerbils, in males 7 and 21 days after castration, and in females treated with testosterone for 7 and 21 days. In male and female adult gerbils, ER alpha was detected mainly in prostatic stromal cells, whereas ER beta was present mostly in secretory and basal cells. More ER alpha-positive stromal cells were found in females than in males, as was a reduction toward the male value in females treated with testosterone. Castration did not alter ER alpha expression. Testosterone was necessary for maintenance of ER beta in the male prostate epithelium: ER beta expression declined markedly in prostates of males older than 1 yr, and castration of 4-mo-old males caused a reduction in ER beta to levels seen in 1-yr-old males. Because ER beta is an antiproliferative receptor, its loss with age may predispose the aging gerbil to proliferative diseases of the prostate. © 2013 by the Society for the Study of Reproduction, Inc.

The development of science and technology indicators in the Caribbean

Includes bibliography

New maritime transport scenarios. Part II: fluctuations in shipping and new scenarios

This FAL Bulletin details the situation of the shipping industry and forms the second and final part of a larger document that begins with Issue No. 338, which puts the current status of maritime trade in context. Both documents fit into a series of bulletins about ports and maritime trade in the region and are, therefore, closely linked to Issue No. 337, which sets out the need for a new port governance in the region to address the new circumstances that have arisen in the maritime market.

Conservação genética in situ de espécies arbóreas que ocorrem na transição da floresta estacional semidecidual e o cerrado em Selvíria – MS

Pós-graduação em Agronomia - FEIS

Controle de Alternaria solani em tomateiro (Lycopersicon esculentum) com óleos essenciais

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O papel da pesca na eficiência reprodutiva dos ribeirinhos do baixo Tocantins: o caso do município de Mocajuba - PA

Este trabalho tem como objetivo analisar o conhecimento das comunidades tradicionais no manejo dos recursos naturais através de sua atividade produtiva, a pesca, na abordagem da Eficiência reprodutiva e na noção de Trajetórias Tecnológicas, e com isso valorizar o saber local atrelado à territorialidade da sua constituição, como cruciais ao sucesso do manejo coletivo como base de um desenvolvimento sustentável. O saber caboclo junto às premissas da eficiência reprodutiva, possibilita um processo racional e inerente dos agentes que constroem estratégias produtivas, fundamentadas na multiespeficidade, em especial, no uso do espaço e da técnica, como principal ação mitigadora a assegurar a sustentabilidade da atividade antrópica no contexto amazônico. Por se tratar de um estudo de caráter qualitativo, foram analisados: a) a formação histórica da pesca na região do Baixo Tocantins, com enfoque no município de Mocajuba, os fundamentos naturais dos cenários espaciais vigentes na área da pesquisa e os aspectos da racionalidade e padrões produtivos e reprodutivos dos agentes econômicos. Os resultados nos revelaram que a racionalidade da eficiência reprodutiva se mostrou eficaz na análise, com o valor encontrado em h convergindo para 1, ou seja, mostra o campo de conforto que a pesca proporciona aos que dela dependem, representada no modus vivendi do ribeirinho, a refletir sua forma de interação social que mesmo no cenário capitalista, são sociedades constituídas, marcantemente, por suas bases sociais familiares entrelaçadas na construção e reconstrução do ambiente natural, a sustentar fortes relações de solidariedade e cooperação como suas marcas principais. A configuração da organização social pesqueira enfatizou o modelo bipolar de divisão, determinada por idade e pelo sexo, assentada na hierarquia doméstica e na relação da força produtiva humana. A evolução tecnológica ocorrida no Baixo Tocantins, afetou a pesca artesanal, e fundamentou novas peculiaridades na otimização do espaço de pesca. Neste sentido, as mudanças tecnológicas, mostram-se, eficientes ao reduzir o tempo de execução e evitar um retrocesso produtivo, sem desvincular do pensamento conservacionista do agente. Ficou evidenciado que a pesca realizada na área de estudo é desenvolvida de forma dinâmica nas distintas modalidades de pesca empregadas a cada ciclo sazonal anual aplicada nos diferentes microhabitats. Desta forma, concluimos neste trabalho que a consciência ecológica do homem do campo e o valor do conhecimento tradicional é de suma importância para o sucesso pesqueiro, entretanto, este saber, é muitas vezes negligenciado pelas autoridades ambientais, mas deve ser considerado e consultado para que se possam subsidiar medidas efetivas de gestão a prosperar o meio ambiente.

Atividade de acaricidas sobre o Ácaro-da-leprose, Brevipalpus phoenicis (Geijskes) (Acari: Tenuipalpidae) e sobre artrópodes benéficos na cultura dos citros

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Perceptions of environmental change and use of traditional knowledge to plan riparian forest restoration with relocated communities in Alcantara, Eastern Amazon

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Involvement of the median preoptic nucleus in blood pressure control

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Aplicação de lógica fuzzy na elaboração de planta de valores genéricos

Pós-graduação em Ciências Cartográficas - FCT