Low expression of human histocompatibility soluble leukocyte antigen-G (HLA-G5) in invasive cervical cancer with and without metastasis, associated with Papilloma Virus (HPV)

Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class Ib molecule that acts as a specific immunosuppressor. Some studies have demonstrated that human papillomavirus (HPV) seems to be involved in lower or absent HLA-G expression, particularly in cervical cancer. In this study, we performed a cross-sectional study, systematically comparing the qualitative expression of the HLA-G5 isoform in invasive cervical carcinoma (ICC), stratifying patients according to the presence [ICC with metastasis (ICCW)] and absence [ICC without metastasis (ICCWT)] of metastasis, correlating these findings with interference of HPV and demographic and clinical variables. Seventy-nine patients with a diagnosis of ICC were stratified into two groups: ICCWT (n=52 patients) and ICCW (n=27). Two biopsies were collected from each patient (one from the tumor lesion and one from a lymph node). Immunohistochemistry analyses were performed for the HLA-G5 isoform, for HPV detection, and virus typing. HLA-G5 isoform molecules were detected in 25 cases (31.6%), 17 (32.7%) without metastasis and 8 (29.6%) with metastasis. HPV was detected in the cervical lesions of 74 patients (93.7%), but low expression of the HLA-G5 isoform was observed in all HPV-related cases. These findings are important; however, additional studies are necessary to identify the influence of HPV with HLA-G5 isoform expression on invasive cervical malignancies.

Estudo clínico retrospectivo de restaurações cerâmicas do tipo laminado sobre dentes com ou sem preparo dentário: 1 a 5 anos de acompanhamento

Pós-graduação em Odontologia - FOA

Descrição anatômica das estruturas osteoarticulares do esqueleto axial do tatu-galinha (Dasypus novemcinctus Linnaeus, 1758) por meio da radiografia e tomografia computadorizada

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A relação entre a sustentabilidade e o design de moda contemporâneo: uma análise sobre o segmento jeanswear

A moda é um dos reflexos que melhor expressa as dinâmicas do contemporâneo, e a sustentabilidade é um dos agentes questionadores do conceito e da abordagem da moda e do design de moda, assim, a proposta deste artigo é apresentar uma análise crítica da relação da moda com a sustentabilidade, com o objetivo de confrontar e verificar os discursos defendidos por empresas do segmento jeanswear e o desenvolvimento de seus produtos de vestuário, chamados de ‘ sustentáveis’. A fundamentação parte da revisão da literatura dessas áreas somada à pesquisa de campo com entrevistas estruturadas, aplicação de questionários e posterior análise das discursos e divulgação por parte das empresas.

Estudo do peptídeo lítico Hecate e sua conjugação com ácido gálico: atividade contra o carcinoma cervical humano, mecanismo de ação e toxicidade

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeito de diversos protocolos de dessensibilização dentinária na obliteração de túbulos dentinários, resistência de união do sistema adesivo e formação de camada hibrida na dentina cervical

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Utilização de painéis solares fotovoltaicos no segmento residencial

In order to diversify the global and national energy matrix and reduce harmful impacts on the environment caused by the emission of polluting gases into the atmosphere, the use of clean and renewable energy sources is presented as a good alternative. This work discusses the use of photovoltaic solar energy, a source that presents such characteristics. The photovoltaic system under study is the type distributed connected to the grid, in the residential segment. It is informed of its use in the global and national levels. They are also present their characteristics, electrical and electronic circuits that make up the equipment required for its operation and the design of a system to be installed in a residence

Análise envoltória de dados combinada com a lógica fuzzy em problemas de avaliação de eficiência de máquinas de consumo: um estudo em empresa do segmento farmacêutico

The pharmaceutical industry was consolidated in Brazil in the 1930s, and since then has become increasingly competitive. Therefore the implementation of the Toyota Production System, which aims to lean production, has become common among companies in the segment. The main efficiency indicator currently used is the Overall Equipment Effectiveness (OEE). This paper intends to, using the fuzzy model DEA-BCC, analyze the efficiency of the production lines of a pharmaceutical company in the Paraíba Valley, compare the values obtained by the model with those calculated by the OEE, identify the most sensitive machines to variation in the data input and develop a ranking of effectiveness between the consumer machinery. After the development, it is shown that the accuracy of the relationship between the two methods is approximately 57% and the line considered the most effective by the Toyota Production System is not the same as the one found by this paper

Programação por metas e análise envoltória de dados na avaliação de unidades de produção global: uma aplicação em uma empresa do segmento químico

Considering the high competitivity in the market, the application of quantitative methods can assist in analyzing the efficiency of production facilities of areas of export and import processes of the chemical industry sector. In this sense, this work aims to apply the model GPDEA-BCC optimization in order to develop an analysis of the production units of this chemical industry. So, were chosen variables relevant to the process and elaborated a final comparison between the results obtained by the optimization tool and performance indexes provided by the company. These results indicated that some production units should be monitored more carefully because some of them had a low efficiency when analyzed with multi criteria

Avaliação do desempenho ambiental e racionalização do consumo de água no segmento industrial de produção de bebidas

A região Amazônica, detentora de grande potencial hídrico, tem atraído indústrias que promovem uso intensivo de água, por isso, existe uma emergência por instrumentos que administrem essa tendência. Neste trabalho foi diagnosticado o nível de racionalização do uso da água pelo setor industrial de produção de bebidas no estado do Pará, assim como as causas do comportamento do setor. As variáveis dependentes (de comportamento) foram classificadas de acordo com quatro dimensões (gestão ambiental, manejo da água, manejo dos efluentes e medidas avançadas de racionalização) que compõe o nível de racionalização da gestão industrial hídrica. As variáveis independentes foram associadas ao: porte, ramo, tipo de embalagem utilizada, disponibilidade hídrica e valor econômico da água. Os dados levantados mostraram que a produção de bebidas tem uma grande pegada hídrica operacional total (acima de) 15.250 m³/dia, com as pequenas empresas apresentando o maior consumo relativo por unidade produzida (maior que 7 L de água/L de bebida). O setor como um todo apresenta baixo nível de racionalização do uso da água, a dimensão mais eficiente é a de gerenciamento da água; entretanto algumas medidas avançadas podem ser visualizadas, especialmente a recirculação da água em torres de resfriamento. A análise das variáveis de estudo demonstra que o nível de racionalização é dependente diretamente do ramo e do porte da empresa. Conclui-se que o consumo tende ao desperdício; em resposta a este quadro, devem ser priorizadas políticas públicas voltadas para internalização dos custos ambientais embutidos no processo.

Efeito de diversos protocolos de dessensibilização dentinária na obliteração de túbulos dentinários, resistência de união do sistema adesivo e formação de camada hibrida na dentina cervical

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Utilização de painéis solares fotovoltaicos no segmento residencial

In order to diversify the global and national energy matrix and reduce harmful impacts on the environment caused by the emission of polluting gases into the atmosphere, the use of clean and renewable energy sources is presented as a good alternative. This work discusses the use of photovoltaic solar energy, a source that presents such characteristics. The photovoltaic system under study is the type distributed connected to the grid, in the residential segment. It is informed of its use in the global and national levels. They are also present their characteristics, electrical and electronic circuits that make up the equipment required for its operation and the design of a system to be installed in a residence

Análise envoltória de dados combinada com a lógica fuzzy em problemas de avaliação de eficiência de máquinas de consumo: um estudo em empresa do segmento farmacêutico

The pharmaceutical industry was consolidated in Brazil in the 1930s, and since then has become increasingly competitive. Therefore the implementation of the Toyota Production System, which aims to lean production, has become common among companies in the segment. The main efficiency indicator currently used is the Overall Equipment Effectiveness (OEE). This paper intends to, using the fuzzy model DEA-BCC, analyze the efficiency of the production lines of a pharmaceutical company in the Paraíba Valley, compare the values obtained by the model with those calculated by the OEE, identify the most sensitive machines to variation in the data input and develop a ranking of effectiveness between the consumer machinery. After the development, it is shown that the accuracy of the relationship between the two methods is approximately 57% and the line considered the most effective by the Toyota Production System is not the same as the one found by this paper

Programação por metas e análise envoltória de dados na avaliação de unidades de produção global: uma aplicação em uma empresa do segmento químico

Considering the high competitivity in the market, the application of quantitative methods can assist in analyzing the efficiency of production facilities of areas of export and import processes of the chemical industry sector. In this sense, this work aims to apply the model GPDEA-BCC optimization in order to develop an analysis of the production units of this chemical industry. So, were chosen variables relevant to the process and elaborated a final comparison between the results obtained by the optimization tool and performance indexes provided by the company. These results indicated that some production units should be monitored more carefully because some of them had a low efficiency when analyzed with multi criteria

CHALLENGES TO THE ORGANIZATION OF A CERVICAL CANCER SCREENING PROGRAM IN MANAUS-AM

The purpose was to investigate sociodemographic characteristics of women who underwent a Pap smear test in Manaus, Amazonas, Brazil, and identify the reasons why the women had the test. This exploratory study was performed with 281 women who had taken the Pap smear test within the last five years in Manaus. Most participants were between 18 to 34 years old (54%), had 5 to 11 years of education (54.4%), had a monthly income of less than three minimum wage salaries (84.3%) and were in a stable relationship (72.2%), with an onset of sexual activity between the ages of 15 to 19 years (69.4%). The reasons for their taking the Pap test were personal choice (66.2%), recommendation by a physician (23.5%) and gynecological symptoms (10.3%). Women who received information about the Pap test from health professionals had a greater chance of being tested within the last three years (p=0.008). Women choosing to have the exam (personal choice) are prevalent, and the opportunistic service is provided to younger women, thus not reaching the group at greater risk for cancer. It is necessary to implement active recruitment strategies to reach women in situations of socioeconomic disadvantage.