A hierarchical approach to model parameter optimization for developmental systems.

In the context of Systems Biology, computer simulations of gene regulatory networks provide a powerful tool to validate hypotheses and to explore possible system behaviors. Nevertheless, modeling a system poses some challenges of its own: especially the step of model calibration is often difficult due to insufficient data. For example when considering developmental systems, mostly qualitative data describing the developmental trajectory is available while common calibration techniques rely on high-resolution quantitative data. Focusing on the calibration of differential equation models for developmental systems, this study investigates different approaches to utilize the available data to overcome these difficulties. More specifically, the fact that developmental processes are hierarchically organized is exploited to increase convergence rates of the calibration process as well as to save computation time. Using a gene regulatory network model for stem cell homeostasis in Arabidopsis thaliana the performance of the different investigated approaches is evaluated, documenting considerable gains provided by the proposed hierarchical approach.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, January 2004

Monthly Public Assistance Statistical Report Family Investment Program

F-1, Food Stamp Program - State Summary, February 2004

The Food Assistance Monthly Participation Report is a monthly summary of Food Assistance program participation, Statewide and for each Iowa county. Breakouts are reported for participants also in the FIP program, those only receiving Food Assistance, and those that are receiving economic assistance under other programs (primarily Medicaid). This report may also be known as the F-1 Report.

A-1A Supplemental Security Income Program, February 2004

Monthly report from Iowa Department of Human Services on income.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, February 2004

Monthly Public Assistance Statistical Report Family Investment Program

A-1A Supplemental Security Income Program, March 2004

Monthly report from the Iowa Department of Human Services on Supplemental Security Income Program (SSI).

F-1, Food Assistance Program - State Summary, April 2004

The Food Assistance Monthly Participation Report is a monthly summary of Food Assistance program participation, Statewide and for each Iowa county. Breakouts are reported for participants also in the FIP program, those only receiving Food Assistance, and those that are receiving economic assistance under other programs (primarily Medicaid). This report may also be known as the F-1 Report.

Annual Report for the Iowa Highway Safety Program, Federal Fiscal Year 2003

Annual Highway Safety Evaluation Report for the Governor's Traffic Safety Bureau, Iowa Department of Public Safety

Annual Report for the Iowa Highway Safety Program, 2000

Annual Highway Safety Evaluation Report for the Governor's Traffic Safety Bureau, Iowa Department of Public Safety

A-1 Monthly Public Assistance Statistical Report Family Investment Program, March 2004

Monthly Public Assistance Statistical Report Family Investment Program

Iowa New Jobs Training Program Annual Report, 2003

Annual Report

A-1A Supplemental Security Income Program, April 2004

Monthly report from the Iowa Department of Human Services on income.

Algorithm optimization for solving crew scheduling problems

In this paper, we are proposing a methodology to determine the most efficient and least costly way of crew pairing optimization. We are developing a methodology based on algorithm optimization on Eclipse opensource IDE using the Java programming language to solve the crew scheduling problems.

Educational Excellence Program for Fiscal Years 1999 - 2002

A Review of the Educational Excellence Program for Fiscal Years 1999 - 2002 and the Student Achievement and Teacher Quality Program for Fiscal Year 2002 within the Department of Education

A-1 Monthly Public Assistance Statistical Report Family Investment Program, April 2004

Monthly Public Assistance Statistical Report Family Investment Program