Nonsuicidal Self-Injury and Suicidal Behavior: A Latent Class Analysis among Young Adults

Although there is a general consensus among researchers that engagement in nonsuicidal self-injury (NSSI) is associated with increased risk for suicidal behavior, little attention has been given to whether suicidal risk varies among individuals engaging in NSSI. To identify individuals with a history of NSSI who are most at risk for suicidal behavior, we examined individual variability in both NSSI and suicidal behavior among a sample of young adults with a history of NSSI (N = 439, Mage = 19.1). Participants completed self-report measures assessing NSSI, suicidal behavior, and psychosocial adjustment (e.g., depressive symptoms, daily hassles). We conducted a latent class analysis using several characteristics of NSSI and suicidal behaviors as class indicators. Three subgroups of individuals were identified: 1) an infrequent NSSI/not high risk for suicidal behavior group, 2) a frequent NSSI/not high risk for suicidal behavior group, and 3) a frequent NSSI/high risk for suicidal behavior group. Follow-up analyses indicated that individuals in the ‘frequent NSSI/high risk for suicidal behavior’ group met the clinical-cut off score for high suicidal risk and reported significantly greater levels of suicidal ideation, attempts, and risk for future suicidal behavior as compared to the other two classes. Thus, this study is the first to identity variability in suicidal risk among individuals engaging in frequent and multiple methods of NSSI. Class 3 was also differentiated by higher levels of psychosocial impairment relative to the other two classes, as well as a comparison group of non-injuring young adults. Results underscore the importance of assessing individual differences in NSSI characteristics, as well as psychosocial impairment, when assessing risk for suicidal behavior.

KLM Airline World Business Class Drink Menu

A menu from the airline KLM World Business Class, featuring the wine of Inniskillin, specifically the Chardonnay Reserve 1994.

Postcolonial entanglements of Power, Race, Class and Privilege in Child and Youth Care Work Within a Brazilian Favela

This research assesses the various aspects of Child and Youth Care (CYC) work and how relationships between child or youth and care provider are limited and constricted within greater political, social and historical contexts. Specifically, this research takes place internationally in Rio de Janeiro, Brazil within a favela (slum) and unveils the entangled and complex relationship that I, not only as an ethnographer, but also as a CYC worker had with the many young people that I encountered. It will address a variety of theories that demonstrate the potentials of reproducing oppressive relationships, and argue that it is imperative for CYC workers to critically reflect on the greater contexts in which their work is situated in order to gain forces with those young people whom they are attempting to serve.

Totals of free goods up – class 3 and class 4

Totals of free goods up – class 3 and class 4 (1 page, handwritten), n.d.

Statement showing the totals of the quantity of each class of articles transported on the Welland Canal during the years ending on the 31st of December 1857-1861

Statement showing the totals of the quantity of each class of articles transported on the Welland Canal during the years ending on the 31st of December 1857-1861 and the amount of tolls collected thereon 2 ½ page, hand drawn chart), Dec. 31, 1861.

Empleo de material didáctico en la materia de Química III módulo VII a nivel medio superior

[Tesis] ( Maestría en Enseñanza Superior) U.A.N.L.

VII anualidad ; prospecto general, julio 1o. septiembre 8 de 1952

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Fernando VII en España : marcha patriótica.

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Historia general de España desde los tiempos primitivos hasta la muerte de Fernando VII

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Concordat, et recueil des bulles et brefs de N. S. P. le Pape Pie VII; sur les affaires actuelles de l' Eglise de France

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Biblia Sacra vulgate editores Sixti V. et Clementis VII Pont. Max. auctroritate recognita, cum notis choronologieis et historicis exemplaris vitreani, et indice geographico J. B. Du-hamel

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Concilii plenarii Baltimorensis II., in ecclesia metropolitana Baltimorensi, VII. ad diem XXI octobris, A.D. MDCCCLXVI., habiti et a sede apostolica recognit: decretar. praeside. illustrissimo ac reverendissimo Martino Joanne Salding.

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Melanosomal targeting sequences from gp100 are essential for MHC class II-restricted endogenous epitope presentation and mobilization to endosomal compartments

CD4+ T lymphocytes play an important role in CD8+ T cell-mediated responses against tumors. Considering that about 20% of melanomas express major histocompatibility complex (MHC) class II, it is plausible that concomitant antigenic presentation by MHC class I and class II complexes shapes positive (helper T cells) or negative (regulatory T cells) anti-tumor responses. Interestingly, gp100, a melanoma antigen, can be presented by both MHC class I and class II when expressed endogenously, suggesting that it can reach endosomal/MHC class II compartments (MIIC). Here, we demonstrated that the gp100 putative amino-terminal signal sequence and the last 70 residues in carboxy-terminus, are essential for MIIC localization and MHC class II presentation. Confocal microscopy analyses confirmed that gp100 was localized in LAMP-1+ endosomal/MIIC. Gp100-targeting sequences were characterized by deleting different sections in the carboxy-terminus (residues 590 to 661). Transfection in 293T cells, expressing MHC class I and class II molecules, revealed that specific deletions in carboxy-terminus resulted in decreased MHC class II presentation, without effects on MHC class I presentation, suggesting a role in MIIC trafficking for these deleted sections. Then, we used these gp100-targeting sequences to mobilize the green fluorescent protein (GFP) to endosomal compartments, and to allow MHC class II and class I presentation of minimal endogenous epitopes. Thus, we concluded that these specific sequences are MIIC targeting motifs. Consequently, these sequences could be included in expression cassettes for endogenously expressed tumor or viral antigens to promote MHC class II and class I presentation and optimize in vivo T cell responses, or as an in vitro tool for characterization of new MHC class II epitopes.

Le droit civil expliqué suivant l'ordre des articles du code : del'echange et du lovage, commentaire des titres VII et VIII du livre III du code Napoleón

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Ordenanzas de la ilustre Universidad y casa de contratación de la M. N. y M. L. Villa de Bilbao, aprobadas y confirmadas por D. Felipe V.y D. Fernando VII con inserción de los reales privilegios, y la provisión de 9 de julio de 1818 que contiene las alteraciones hechas a solicitud del mismo Consulado y comercio.

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