1000 resultados para advanced


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The effect of composition and processing schedule on the microstructure of C-Mn-Si-Mo-(Al)-(Nb) steels containing nano-bainite was studied using transmission electron microscopy (TEM) and atom probe tomography (APT). The major phase formed in all steels was nano-bainite. However, the steels with lower carbon and alloying addition content subjected to TMP had better mechanical properties than high alloyed steel after isothermal treatment. The presence of ferrite in the microstructure can improve not only ductility but lead to the formation of retained austenite with optimum chemical stability.

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As one of the primary substances in a living organism, protein defines the character of each cell by interacting with the cellular environment to promote the cell’s growth and function [1]. Previous studies on proteomics indicate that the functions of different proteins could be assigned based upon protein structures [2,3]. The knowledge on protein structures gives us an overview of protein fold space and is helpful for the understanding of the evolutionary principles behind structure. By observing the architectures and topologies of the protein families, biological processes can be investigated more directly with much higher resolution and finer detail. For this reason, the analysis of protein, its structure and the interaction with the other materials is emerging as an important problem in bioinformatics. However, the determination of protein structures is experimentally expensive and time consuming, this makes scientists largely dependent on sequence rather than more general structure to infer the function of the protein at the present time. For this reason, data mining technology is introduced into this area to provide more efficient data processing and knowledge discovery approaches.

Unlike many data mining applications which lack available data, the protein structure determination problem and its interaction study, on the contrary, could utilize a vast amount of biologically relevant information on protein and its interaction, such as the protein data bank (PDB) [4], the structural classification of proteins (SCOP) databases [5], CATH databases [6], UniProt [7], and others. The difficulty of predicting protein structures, specially its 3D structures, and the interactions between proteins as shown in Figure 6.1, lies in the computational complexity of the data. Although a large number of approaches have been developed to determine the protein structures such as ab initio modelling [8], homology modelling [9] and threading [10], more efficient and reliable methods are still greatly needed.

In this chapter, we will introduce a state-of-the-art data mining technique, graph mining, which is good at defining and discovering interesting structural patterns in graphical data sets, and take advantage of its expressive power to study protein structures, including protein structure prediction and comparison, and protein-protein interaction (PPI). The current graph pattern mining methods will be described, and typical algorithms will be presented, together with their applications in the protein structure analysis.

The rest of the chapter is organized as follows: Section 6.2 will give a brief introduction of the fundamental knowledge of protein, the publicly accessible protein data resources and the current research status of protein analysis; in Section 6.3, we will pay attention to one of the state-of-the-art data mining methods, graph mining; then Section 6.4 surveys several existing work for protein structure analysis using advanced graph mining methods in the recent decade; finally, in Section 6.5, a conclusion with potential further work will be summarized.

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The key evidence for understanding the mechanical behavior of advanced high strength steels was provided by atom probe tomography (APT). Chemical overstabilization of retained austenite (RA) leading to the limited transformation-induced plasticity (TRIP) effect was deemed to be the main factor responsible for the low ductility of nanostructured bainitic steel. Appearance of the yield point on the stress-strain curve of prestrained and bake-hardened transformationinduced plasticity steel is due to the unlocking from weak carbon atmospheres of newly formed during prestraining dislocations.

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The microstructure-property relationship in conventional high strength low alloy (HSLA) steel was evaluated using data obtained from transmission electron microscopy (TEM) and atom probe tomography (APT). Atom probe tomography allowed the characterisation of fine TiC particles with average radius of 3±1·2 nm that were not observed by TEM. The increase in the yield strength of steel due to the presence of fine precipitates was calculated to be 128 MPa.

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This dataset is comprised of a spreadsheet of simulation result files, cross-section geometries of stamped parts, strain results of cross-section of stamped parts, simulation data (strain stress displacement energies), and variation data of material properties of a single coil. This data is a collection of both experimental and simulation results from industrial and laboratory stamping of advanced high strength steels (AHSS). The steels that were stamped were a typical high-strength low-alloy (HSLA) steel, a transformation-induced plasticity (TRIP) steel, a super HSLA steel, and a dual phase (DP) steel. The selected part was an automatic Ford Falcon front cross-member component using the Ford Geelong stamping plant. The variation of the material and stamped parts was also collected.

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A 0.79C-1.5Si-1.98Mn-0.98Cr-0.24Mo-1.06Al-1.58Co (wt%) steel was isothermally heat treated at 350°C bainitic transformation temperature for 1 day to form fully bainitic structure with nano-layers of bainitic ferrite and retained austenite, while a 0.26C-1.96Si-2Mn-0.31Mo (wt%) steel was subjected to a successive isothermal heat treatment at 700°C for 300 min followed by 350°C for 120 min to form a hybrid microstructure consisting of ductile ferrite and fine scale bainite. The dislocation density and morphology of bainitic ferrite, and retained austenite characteristics such as size, and volume fraction were studied using Transmission Electron Microscopy. It was found that bainitic ferrite has high dislocation density for both steels. The retained austenite characteristics and bainite morphology were affected by composition of steels. Atom Probe Tomography (APT) has the high spatial resolution required for accurate determination of the carbon content of the bainitic ferrite and retained austenite, the solute distribution between these phases and calculation of the local composition of fine clusters and particles that allows to provide detailed insight into the bainite transformation of the steels. The carbon content of bainitic ferrite in both steels was found to be higher compared to the para-equilibrium level of carbon in ferrite. APT also revealed the presence of fine C-rich clusters and Fe-C carbides in bainitic ferrite of both steels.

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The nano-bainitic microstructures were compared in a 0.79C-1.5Si-1.98Mn-0.24Mo-1.06Al (wt%) steel after isothermal heat-treatment and a Fe-0.2C-1.5Mn-1.2Si-0.3M0-0.6Al-0.02Nb (wt%) steel after controlled thermo-mechanical processing. The microstructure for both steels consisted of bainite. The microstructural characteristics of bainite, such as the morphology of the nano-bainite and thicknesses of bainitic ferrite and retained austenite layers, as a function of steel composition and processing was studied using transmission electron microscopy (TEM). It was found that the nano-bainitic structure can be formed in the low alloy steel through thermomechanical processing. Atom probe tomography (APT) was employed as a powerful technique to determine local composition distributions in three dimensions with atomic resolution. The important conclusions from the APT research were that the carbon content of bainitic ferrite is higher than expected from paraequilibrium level of carbon in ferrite for both steels and that Fe-C clusters and fine particles are formed in the bainitic ferrite in both steels despite the high level of Si.

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Study guide for TAFE management unit in Victoria.

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There is increased awareness regarding the benefits of ultrasound for vascular access surveillance and guided cannulation in haemodialysis. However, finding time to train staff whilst working within the clinical setting is challenging. In 2009 a workshop was introduced in Victoria to provide a platform for nursing staff to learn advanced skills in surveillance and cannulation in a safe, supportive environment. The workshop covered topics such as: assessment and cannulation; surgical perspectives in vascular access; radiological perspectives in vascular access; surveillance and monitoring; cannulation competency package; antegrade/antegrade cannulation; and introduction to ultrasound plus five hours of practical sessions. Feedback from the workshop over the past three years has been positive, and staff have benefited from the both the theoretical and clinical components of the workshop. The success of this workshop highlights the demand for continuing education within the renal workforce.