Switching Axial Progenitors from Producing Trunk to Tail Tissues in Vertebrate Embryos

The vertebrate body is made by progressive addition of new tissue from progenitors at the posterior embryonic end. Axial extension involves different mechanisms that produce internal organs in the trunk but not in the tail. We show that Gdf11 signaling is a major coordinator of the trunk-to-tail transition. Without Gdf11 signaling, the switch from trunk to tail is significantly delayed, and its premature activation brings the hindlimbs and cloaca next to the forelimbs, leaving extremely short trunks. Gdf11 activity includes activation of Isl1 to promote formation of the hindlimbs and cloaca-associated mesoderm as the most posterior derivatives of lateral mesoderm progenitors. Gdf11 also coordinates reallocation of bipotent neuromesodermal progenitors from the anterior primitive streak to the tail bud, in part by reducing the retinoic acid available to the progenitors. Our findings provide a perspective to understand the evolution of the vertebrate body plan.

Political Sophistication and Vote Intention Switching

This article investigates the link between political sophistication and electoral volatility. Showing that there is disagreement in the literature on whether switching party preferences is related to low or high levels of political sophistication, it is then argued that the effect of sophistication on vote switching might differ depending on when switching is measured. The effect of timing on volatility is investigated by means of the Short-term panel of the 2009 German Longitudinal Election Study. Results indicate that timing indeed matters, while sophistication increases the probability of switching parties before the campaign, the effect of political sophistication becomes more negative as Election Day draws near.

Adult attention-deficit/hyperactivity disorder and nicotine withdrawal: a qualitative study of patient perceptions

Background: Nicotine use has been reported to ameliorate symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD). Furthermore, adults with ADHD have a relatively high prevalence of cigarette smoking and greater difficulty abstaining from smoking. Overall, though, there is scant literature investigating the beliefs, perceptions and experiences of smokers with ADHD regarding smoking cessation and withdrawal. Methods: Our participants (n = 20) fulfilling criteria for ADHD and a past or current dependence from nicotine were recruited from the in- and outpatient clinic of the Zurich University Psychiatric Hospital and the Psychiatric Services Aargau (Switzerland). We conducted in-depth interviews to explore their motivations to quit, past experiences with and expectations about quitting using a purposeful sampling plan. The sample was selected to provide diversity in relation to level of nicotine dependence, participation in a smoking-cessation program, gender, age, martial status and social class. Mayring’s qualitative content analysis approach was used to evaluate findings. Results: Adult smokers with ADHD had made several attempts to quit, experienced intense withdrawal symptoms, and relapsed early and often. They also often perceived a worsening of ADHD symptoms with nicotine abstinence. We identified three motives to quit smoking: 1) health concerns, 2) the feeling of being addicted, and 3) social factors. Most participants favored a smoking cessation program specifically designed for individuals with ADHD because they thought ADHD complicated their nicotine withdrawal and that an ADHD-specific smoking cessation program should address specific symptoms of this disorder. Conclusions: Since treatment initiation and adherence associate closely with perception, we hope these findings will result in better cessation interventions for the vulnerable subgroup of smokers with ADHD. Keywords: ADHD, Nicotine, Withdrawal, Subjective, Qualitative, Narrative

UMTA's research and development program should pay closer attention to transit industry needs.

Mode of access: Internet.

Driver performance and individual differences in attention and information processing. Volume I: driver inattention. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Driver performance and individual differences in attention and information processing. Volume II: field dependence and highway safety. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Antiquités de la ville de Lyon, ou, Explication de ses plus anciens monumens : avec des recherches sur les autres choses remarquables, qui peuvent attirer l'attention des etrangers /

Some plates signed by Ferdinand Delamonce.

Defense inventory : top management attention is crucial : report to the Secretary of Defense /

"B-222859"--P. 1.

DWI detection and divided attention field sobriety testing: a self instructional training program for law enforcement officers. Final report.

Mode of access: Internet.