Spastic Paraplegia, Optic Atrophy, and Neuropathy: New Observations, Locus Refinement, and Exclusion of Candidate Genes

SPOAN is an autosomal recessive neurodegenerative disorder which was recently characterized by our group in a large inbred Brazilian family with 25 affected individuals. This condition is clinically defined by: 1. congenital optic atrophy; 2. progressive spastic paraplegia with onset in infancy; and 3. progressive motor and sensory axonal neuropathy. Overall, we are now aware of 68 SPOAN patients (45 females and 23 males, with age ranging from 5 to 72 years), 44 of which are presented here for the first time. They were all born in the same geographic micro region. Those 68 patients belong to 43 sibships, 40 of which exhibit parental consanguinity. Sixty-one patients were fully clinically evaluated and 64 were included in the genetic investigation. All molecularly studied patients are homozygotes for D11S1889 at 11q13. This enabled us to reduce the critical region for the SPOAN gene from 4.8 to 2.3 Mb, with a maximum two point lod score of 33.2 (with marker D11S987) and of 27.0 (with marker D11S1889). Three genes located in this newly defined critical region were sequenced, but no pathogenic mutation was detected. The gene responsible for SPOAN remains elusive.

Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice

Aromatherapy uses essential oils (EOs) for several medical purposes, including relaxation. The association between the use of aromas and a decrease in anxiety could be a valuable instrument in managing anxiety in an ever increasing anxiogenic daily life style. Linalool is a monoterpene commonly found as the major volatile component of EOs in several aromatic plant species. Adding to previously reported sedative effects of inhaled linalool, the aim of this study was to investigate the effects of inhaled linalool on anxiety, aggressiveness and social interaction in mice. Additionally, we investigated the effects of inhaled linalool on the acquisition phase of a step-down memory task in mice. Inhaled linalool showed anxiolytic properties in the light/dark test, increased social interaction and decreased aggressive behavior; impaired memory was only seen the higher dose of linalool. These results strengthen the suggestion that inhaling linalool rich essential oils can be useful as a mean to attain relaxation and counteract anxiety. (C) 2009 Elsevier GmbH. All rights reserved.

Writing-to-Learn Using Social Pedagogy and Technology

Accounting faculty from LaGuardia will share the structure and results of an initiative centered on using ePortfolio and social pedagogy to facilitate writing-to-learn for accounting students. Through a series of ePortfolio-based assignments that connected two classes, along with an in-class writing workshop conducted by non-discipline faculty, students worked together to understand the importance of writing in the accounting discipline and strengthened their writing abilities.

Pregnant Adolescents in Vietnam : Social context and health care needs

Background: The number of childbearing adolescents in Vietnam is relatively low but they are more prone to experience adverse outcome than adult women. Reports of increasing rates of abortion and prevalence of STIs including HIV among youth indicate a need to improve services and counselling for these groups. Midwives are key persons in the promotion of young people’s sexual and reproductive health in Vietnam. Aim: The overall aim of this thesis is to describe the prevalence and outcome of adolescent pregnancies in Vietnam (I), to explore the social context and health care seeking behavior of pregnant adolescents (II), as well as to explore the perspectives of health care providers and midwifery students regarding adolescent sexuality and reproductive health service needs (III, IV). Methods: The studies were conducted from 2002 to 2005, combining qualitative and quantitative research methods. A population based prospective survey was used to estimate rates and outcomes of adolescent pregnancies (I). Pregnant and newly delivered adolescents’ experiences of childbearing and their encounters with health care providers were studied using qualitative interviews (II). Health care providers’ perspective on adolescent sexual and reproductive health (ASRH) and views on how to improve the quality of abortion care was explored in focus group discussions (FGD). The values and attitudes of midwifery students about ASRH were investigated using questionnaires and interviews (IV). Descriptive statistics was used to analyse quantitative data (I, IV) and content analysis were applied for qualitative data (II, III, and IV). Findings: Adolescent birth rate was similar to previously reported in Vietnam but lower when compared to other Asian countries. The incidence of stillborn among adolescents was higher than for women in higher reproductive ages. The proportion of preterm deliveries was 20 % of all births, higher than previous findings from Vietnam. About 2 % of the deliveries were home deliveries, more common among women with low education, belonging to ethnic minority and/or living in mountainous areas (I). Ambivalence facing motherhood, pride and happiness but also worries and lack of self-confidence emerged as themes from the interviews; and experience of ‘being in the hands of others’ in a positive, caring sense but also in a sense of subordination in relation to husband, family and health care providers (II). Health care providers at abortion clinics and midwifery students generally disapproved of pre-marital sex, but had a pragmatic view on the need for contraceptive services and counselling to reduce the burden of unwanted pregnancies and abortions for young women. Providers and midwifery students expressed a need for training on ASRH issues (III, IV). Conclusion: Cultural norms and gender inequity make pregnant adolescent women in Vietnam vulnerable to sexual and reproductive health risks. Health care providers experience ethical dilemmas while counselling unmarried adolescents who come for abortion and this has a negative impact on the quality of care. Integrated ASRH in education and training programmes for health care providers, including midwives, as well as continued in-service training on these issues are suggested to improve reproductive health care services in Vietnam.

Responsabilidade social da Light e suas contribuições para comunidade: um estudo de caso sobre desenvolvimento humano sustentável, inclusão social e cidadania

Esta dissertação apresenta a responsabilidade social das organizações, mais especificamente as contribuições para a comunidade na qual está inserida, tomando-se como estudo de caso a LIGHT. Elementos concernentes à referida responsabilidade social e ao 'programa de normalização de áreas informais' são analisados por meio da metodologia grounded theory. Desta forma, o objetivo maior do estudo é aumentar o entendimento acerca dos valores substantivos gerados no processo estabelecido entre a organização e a comunidade, na busca pelas dimensões da responsabilidade social e seu relacionamento com desenvolvimento humano sustentável, inclusão social e cidadania

Thinking from the South: brazilian social thought and the case of Euclides da Cunha

The article presents the main ideas of Euclides da Cunha (1866-1909), a famous Brazilian intellectual from the beginning of the twentieth-century. Da Cunha was one of the first writers to provide a proto-sociological account of subaltern people in Brazil. The aim of the article is to review his contributions in the light of contemporary discussions concerning postcolonialism and decolonisation.

Deficientes visuais nas organizações: a exclusão no processo de inclusão

O presente estudo objetivou identificar como ocorre o processo de inclusão e exclusão do deficiente visual nas organizações, considerando tal deficiência como a mais representativa das deficiências no país. Apesar desse dado, os profissionais cegos são os que possuem menor índice de contratação pelas empresas, que optam por pessoas que possuem as chamadas “deficiências leves” para compor seu quadro de funcionários. Os deficientes visuais sofrem pelo estereótipo de incapacidade que carregam ao longo da história, mesmo com a presença da Lei de Cotas. Para a construção do estudo foi realizada uma pesquisa de campo, que contou com entrevistas semiestruturadas e observação participante. A conclusão a que se chegou sobre o processo de inclusão do deficiente visual, é que este ocorre praticamente no discurso dos representantes de RH das empresas, sendo visível a preferência de contratação de pessoas com deficiências consideradas “leves”, apesar do número de profissionais cegos disponíveis. O estereótipo de incapacidade laborativa aparece ligado a esse processo de exclusão do cego, que demonstra ocorrer por desconhecimento acerca da deficiência visual. Novas construções foram encontradas, como o estereótipo oriundo do próprio cego e também do direcionamento que instituições importantes apresentam para o desenvolvimento de deficientes visuais, que podem afetar de forma significativa a forma como se relacionam com os videntes.

Corporate social responsibility and environmental sustainability: classification of the initiatives of the FMCG companies operating in Brazil

Este trabalho tem como objetivo fornecer uma análise detalhada do cenário da sustentabilidade ambiental e iniciativas de responsabilidade social corporativa nas empresas que operam no mercado de bens de consumo brasileiro. Para alcançar este objetivo as dez maiores empresas do mercado-alvo presente no Brasil foram analisadas por meio da classificação das suas iniciativas em três perspectivas amplas. Com esta classificação o cenário do mercado pode ser visto. As perspectivas utilizadas para a elaboração do trabalho são: (1) iniciativa ambiental ou social; (2) o foco interno ou externo e (3) a marca ou o custo como motivador. Depois de classificar todas as iniciativas, foi possível ver que as empresas similares, que operam em mercados semelhantes, têm estratégias que são muito parecidos entre si. Além disso, ficou claro que a estratégia de negócios da empresa influencia as suas políticas ambientais e sociais, em particular os objetivos que estas políticas procuram obter.Embora este trabalho apresente um panorama abrangente do setor de bens de consumo em relação a políticas de comportamento responsável das empresas, ele tem algumas limitações. A limitação mais significativa diz respeito a metodologia. As iniciativas foram avaliadas pela quantidade e a abrangência dos benefícios do impacto positivo não foram avaliados, impossibilitando assim a comparação do tamanho do impacto de cada empresa. Uma vez que pode haver um projeto de uma empresa que tem maior impacto do que vários outros feitos por alguma outra empresa. A metodologia foi baseada em clusters de categorias, no entanto, as iniciativas não são completamente uma coisa ou outra, ou seja, uma iniciativa pode ter diferentes impactos, drivers ou foco, nesses casos, os aspectos mais relevantes foram a escolhidos para classificá-los.

Domestic violence in Brazil: social problems and legislative interventions

Recent statistical data confirms that domestic violence is a structural problem of exceptional gravity. We analyze the frequent legislative changes in Brazil since 2000 as a result of social pressure for protection of abused women. Only the Law 11.340 of 2006 was well received by lawyers, judges and the public opinion. We present the innovations and peculiarities of this statute and the allegations on unconstitutionality. We discuss cases of judicial review of this law and reject the arguments of unconstitutionality. That notwithstanding, we argue that penalization decisions is the wrong way from a criminological point of view because they do not take into consideration the desires and needs of the victims.

Social norms and money

In an economy where there is no double coincidence of wants and without recordkeeping of past transactions, money is usually seen as the only mechanism that can support exchange. In this paper, we show that, as long as the population is finite and agents are sufficiently patient, a social norm establishing gift-exchange can substitute for money. Notwithstanding, for a given discount factor, the growth of the population size eventually leads to the breakdown of the social norm, while money still works. 1 Introduction

Linkages between pro-poor growth, social programmes and labour market : the recent Brazilian experience

From a methodological point of view, this paper makes two contlibutions to the literature. One contribution is the proposal of a new measure of pro-poor growth. This new measure provides the linkage between growth rates in mean income and in income inequality. In this context, growth is defined as pro-poor (or anti-poor) if there is a gain (or loss) in the growth rate due to a decrease (or increase) in inequality. The other contribution is a decomposition methodology that explores linkages between three dimensions: growth pattems, labour market performances. and social policies. Through the decomposition analysis, growth in per capita income is explained in terms of four labour market components: the employment rate. hours of work, the labour force participation rate. and productivity. We also assess the contribution of different nonlabour income sources to growth patterns. The proposed methodologies are then applied to the Brazilian National Household Survey (PNAD) covering the period 1995-2004. The paper analyzes the evolution of Brazilian social indicators based on per capita income exploring links with adverse labour market performance and social policy change, with particular emphasis on the expansion of targeted cash transfers and devising more propoor social security benefits.