Resolution 631(XXXI): Place of the next session

Includes bibliography

Resolution 656(XXXIII) Place of the next session

Includes bibliography

Resolution 643(XXXII) Place of the next session

Includes bibliography

Resolution 661(XXXIV) Place of the next session

Spanish version available

Stress Abolishes the Effect of Previous Chronic Ethanol Consumption on Drug Place Preference and on the Mesocorticolimbic Brain Pathway

BackgroundConditioned place preference (CPP) to ethanol (EtOH) is an important addiction-related alteration thought to be mediated by changed neurotransmission in the mesocorticolimbic brain pathway. Stress is a factor of major importance for the initiation, maintenance, and reinstatement of drug abuse and modulates the neurochemical outcomes of drugs. Thus, the aim of this study was to investigate the effects of concomitant exposure to chronic EtOH and stress on CPP to this drug and alterations of dopaminergic and serotonergic neurotransmission in mice.MethodsMale Swiss mice were chronically treated with EtOH via a liquid diet and were exposed to forced swimming stress. After treatment, animals were evaluated for conditioning, extinction, and reinstatement of CPP to EtOH. Also, mice exposed to the same treatment protocol had their prefrontal cortex (PFC), nucleus accumbens (NAc), and amygdala dissected for the quantitation of dopamine, serotonin, and their metabolites content.ResultsData showed that previous chronic exposure to EtOH potentiated EtOH conditioning and increased dopaminergic turnover in PFC. Exposure to stress potentiated EtOH conditioning and decreased dopaminergic turnover in the NAc. However, animals exposed to both chronic EtOH and stress did not display alterations of CPP and showed an elevated content of dopamine in amygdala. No treatment yielded serotonergic changes.ConclusionsThe present study indicates that previous EtOH consumption as well as stress exposure induces increased EtOH conditioning, which can be related to dopaminergic alterations in the PFC or NAc. Interestingly, concomitant exposure to both stimuli abolished each other's effect on conditioning and PFC or NAc alterations. This protective outcome can be related to the dopaminergic increase in the amygdala.

Double-lumen catheter in the right jugular vein induces two sub-endothelial abscesses in an unusual place, the transition between the superior vena cava and the right atrium: a case report

Endocarditis is a type of infection that is common in internal medicine wards and in haemodialysis clinics. The location that is most affected are the heart valves. Herein, we report a case of an uncommon abscess, a sub-endothelial abscess between the transition of the superior vena cava and the right atrium. There were several emboli to the lung and foot, and the agent was related to Staphylococcus aureus and a double-lumen catheter. Usually, this type of abscess is located in valves, either the tricuspid valve if related to catheters or injection drug use or the mitral valve if related to other causes. An exhaustive review was made, but we found no information about the location of this abscess and the rarity of the event motivating the report of infection.

Nasalance during use of pharyngeal and glottal place of production

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A Controlled Experiment Assessing Test Case Prioritization Techniques via Mutation Faults

Regression testing is an important part of software maintenance, but it can also be very expensive. To reduce this expense, software testers may prioritize their test cases so that those that are more important are run earlier in the regression testing process. Previous work has shown that prioritization can improve a test suite’s rate of fault detection, but the assessment of prioritization techniques has been limited to hand-seeded faults, primarily due to the belief that such faults are more realistic than automatically generated (mutation) faults. A recent empirical study, however, suggests that mutation faults can be representative of real faults. We have therefore designed and performed a controlled experiment to assess the ability of prioritization techniques to improve the rate of fault detection techniques, measured relative to mutation faults. Our results show that prioritization can be effective relative to the faults considered, and they expose ways in which that effectiveness can vary with characteristics of faults and test suites. We also compare our results to those collected earlier with respect to the relationship between hand-seeded faults and mutation faults, and the implications this has for researchers performing empirical studies of prioritization.

Incorporating Varying Test Costs and Fault Severities into Test Case Prioritization

Test case prioritization techniques schedule test cases for regression testing in an order that increases their ability to meet some performance goal. One performance goal, rate offault detection, measures how quickly faults are detected within the testing process. In previous work we provided a metric, APFD, for measuring rate of fault detection, and techniques for prioritizing test cases to improve APFD, and reported the results of experiments using those techniques. This metric and these techniques, however, applied only in cases in which test costs and fault severity are uniform. In this paper, we present a new metric for assessing the rate of fault detection of prioritized test cases, that incorporates varying test case and fault costs. We present the results of a case study illustrating the application of the metric. This study raises several practical questions that might arise in applying test case prioritization; we discuss how practitioners could go about answering these questions.