Gato-do-mato-pequeno (Leopardus tigrinus) na Caatinga: ocupação e padrão de atividade de um felídeo ameaçado e pouco conhecido na floresta tropical seca do nordeste do Brasil

While the carnivores are considered regulators and structuring of natural communities are also extremely threatened by human activities. Endangered little-spotted-cat (Leopardus tigrinus) is one of the lesser known species from the Neotropical cats. In this work we investigate the occupancy and the activity pattern of L. tigrinus in Caatinga of Rio Grande do Norte testing: 1) how environmental and anthropogenic factors influence their occupation and 2) how biotic and abiotic factors influence their activity pattern. For this we raised occurrence data of species in 10 priority areas for conservation. We built hierarchical models of occupancy based on maximum likelihood to represent biological hypotheses which were ranked using the Akaike Information Criterion (AIC). According to the results the feline occupancy is more likely away from rural settlements and in areas with a higher proportion of woody vegetation. The opportunistic killing of L. tigrinus and in retaliation for poultry predation close to residential areas can explain this result; as well as more complex vegetation structure can better serve as refuge and ensure more food. Analyzing the records of the species through circular statistics we conclude that the activity pattern is mostly nocturnal, although considerable crepuscular and a small diurnal activity. L. tigrinus activity was directly affected by the availability of small terrestrial mammals, which are essentially nocturnal. In addition, the temperatures recorded in the environment directly and indirectly affect the activity of the little-spotted-cat, as also influence the activity of their potential prey. Generally, the cats were more active when possible prey were active, and this happened at night when lower temperatures are recorded. Moreover, the different lunar phases did not affect the activity pattern. The results improve the understanding of an endangered feline inhabiting the Caatinga biome, and thus can help develop conservation and management strategies, as well as in planning future research in this semi-arid ecosystem.

Padrão epidemiológico das oclusopatias muito graves em adolescentes brasileiros

OBJECTIVE: To describe the distribution of malocclusion and its associated factors in Brazilian adolescents. METHODS: Data from 7,328 subjects aged 12 years and 5,445 adolescents aged 15-19 years were analyzed. The adolescents took part in the Brazilian Oral Health Survey (SBBrasil 2010). The outcome was severe malocclusion according to the dental aesthetic index. The independent variables were sex, skin color, monthly household income, possessions, number of individuals in the household, untreated dental caries, missing teeth and dental appointments or lack thereof, frequency, and reason. Logistical regression analysis was carried out, considering the complex sampling cluster design, based on a hierarchical model. RESULTS: The prevalence of severe malocclusion was 6.5% and 9.1% in the 12-year-olds and the 15-19-year-olds, respectively. After adjustment, those with lighter- skinned black or black skin were 1.59 (95%CI 1.08;2.34) times more likely to present the outcome compared with those with white skin. The loss of one or more first molars increased 2.66 (95%CI 1.26;5.63) the chance to present severe malocclusion by the age of 12. Adolescents aged 15-19 whose household income was below R$ 1,500.00 (OR 2.69 [95%CI 1.62; 4.47]) and those who had seen a dentist for treatment (OR 2.59 [95%CI 2.55;4.34]) had the greatest chance of having severe malocclusion compared with those with higher incomes and those who visited the dentist for prevention.

Padrão de especialização comercial e crescimento econômico : uma análise sobre o Brasil no contexto da fragmentação da produção e das cadeias globais de valor

Globalization and technological changes that has happened since the 80s have brought remarkable changes in the industrial and commercial paradigm, which are expressed mainly in the international fragmentation of production and in the formation of Global Value Chains (GVC). This thesis sought to understand such phenomena and discuss new relevant variables in this context for a more accurate analysis of the current trade patterns not addressed by the seminal economic theories that relate trade and economic growth. It sought to evaluate how the trade specialization pattern of Brazil evolved compared to other economies (China, India, Russia, United States, Japan and selected Latin American economies) in the light of these phenomena from 1995 to 2011. Therefore, we have used the methodology of gross exports decomposition in value added measures, developed by Koopman et al. (2014), and indicators estimated from data of two global matrices I-O: a WIOT (2013) and the TiVA (2015). It was also tested two hypotheses regarding the role of these phenomena as determinants of economic growth in recent years: 1º) fragmentation and participation in GVC ensure higher growth rates for countries; 2º) the place (stage) in which the country finds itself in GVC associated with sectoral technological aspects is also important for economic growth. For this, we used dynamic panel models (Difference GMM and System GMM) for a sample of 40 countries from 2003 to 2011. The studies carried out on Brazil show that the country is no longer on the margins of these phenomena, because it shows increasing rates of participation in GVC, including in sectors considered most strategic for fragmentation. However, there is not a standard convergence of trade specialization of the country to those presented by developed countries or movements earned by China and Mexico in terms of their position and profile of participating in GVC. Another important result obtained by the thesis is the identification of these phenomena are in fact new variables relevant for economic growth, because it shows empirical evidences to support the hypothesis 1 and, partially, the hypothesis 2. A joint analysis of the estimated econometric results with the results of the descriptive analysis of the Brazilian economy, it leads us to conclude that the trade specialization pattern of the country in the context of the new trade setups is presented unfavorably to its growth strategy.

Padrão de especialização e saldo comercial da China com Estados Unidos, Europa e Ásia no início do Século XXI

The rise of China has been providing various effects on developed and developing countries, particularly its Asian neighbors which compete in third markets, such as the U.S., Europe and Japan this sense, the present study aimed to analyze the pattern of Chinese trade with two different groups of countries: the Asian neighbors (Asian Tigers and Dragons) and developed countries (United States, Europe and Japan) during the 2000s. To this end, this paper adopts the methodology of second breakdown of trade technological intensity proposed by Lall (2000). Furthermore, to analyze the intensity of trade between these economies as well as potential threats over their Chinese business partners close, we calculated the following indicators of trade: Trade Intensity Index (TII), Trade Orientation Index (TOI) , Intra-Industry Trade Index (ICII), Index Of Revealed Comparative Advantage (RCA), and, finally, the Contribution To The Balance Index (ICS). The main result achieved is the existence of China\'s trade patterns differ for each group of countries, according to the type of expertise of each partner.

Serviço de videochamada utilizando o padrão o HbbTV: myPhoneOnTV

Nos últimos anos tem-se verificado que a população portuguesa está cada vez mais envelhecida. Este fator agrava-se em ambientes rurais, onde a desertificação populacional é mais frequente, derivado, entre outros, da migração da população mais jovem para os grandes centros urbanos, em busca de melhores condições de vida. Tendo como consequência a exclusão social da população residente nestas zonas. O reduzido foco populacional das zonas rurais não é um fator atrativo para as entidades que realizam investimentos em serviços e infraestruturas tecnológicas, devido ao retorno financeiro obtido não ser, à partida, rentável. Levando a uma exclusão tecnológica de quem reside nestas zonas. Este fator, agrava-se na população sénior dado que raramente são estimulados a interagir com a tecnologia. Com o objetivo de contribuir para a melhoria desta problemática, combatendo simultaneamente os dois tipos de exclusões, tecnológica e social, propõem-se através desta dissertação, um serviço de videochamada, baseado no conceito do padrão Hybrid Broadcast Broadband TV (HbbTV). Um dos fatores considerados, durante o estudo deste serviço, foi a barreira tecnológica existente entre os idosos e a tecnologia. De modo a aproximar ambos, optou-se por aproveitar os conhecimentos que os idosos já possuem na utilização de equipamentos do seu quotidiano. Sendo a televisão, o equipamento selecionado para integrar no serviço de videochamada, permitindo ao idoso contactar facilmente com outras pessoas e serviços. Através da implementação de um protótipo e dos resultados obtidos, conclui-se que o serviço desenvolvido é uma solução válida para combater a problemática apresentada, contribuindo positivamente para a redução da exclusão social e da iliteracia tecnológica

Competências inovativas e a acumulação do conhecimento: um estudo de caso em uma inovação tecnológica da pecuária de corte

Este artigo tem como objetivo descrever o processo de gerar competências inovadoras na Empresa Brasileira de Pesquisa Agropecuária. No inicio de 1980, o centro de pesquisa da Embrapa Gado de Corte estava engajado no projeto Marandu - Brachiaria brizantha - originalmente uma planta nativa da África, potencialmente usada para alimentação do gado. Atualmente é responsável por cerca de 40% das sementes de forrageiras vendidas no Brasil, cultivada em cerca de 70 milhões de hectares de pastagens no país. Uma abordagem qualitativa foi definida para a pesquisa exploratória, e delineamento de estudo de caso. Foram feitas entrevistas semiestruturadas com os pesquisadores envolvidos no projeto e examinado os processos de geração, armazenamento, distribuição e aplicação do modelo de conhecimento tecnológico aplicado pela Embrapa. Os resultados obtidos evidenciam a relevância do ciclo de geração de competências nos processos da gestão do conhecimento, essenciais nas tecnologias da pecuária de corte do agronegócio.

Influência da adição de resíduo de caulim nas propriedades tecnológicas de uma massa padrão de porcelanato produzido em escala industrial

VARELA, M. L. et al. Influência da adição de resíduo de caulim nas propriedades tecnológicas de uma massa padrão de porcelanato produzido em escala industrial. Cerâmica, v.55, n.334 p.209-215. 2009.ISSN 0366-6913.Disponível em: . Acesso em: 06 out. 2010.

O processo de acumulação na economia política clássica: uma interpretação não convencional a partir da leitura dos ricos detalhes comumente inexplorados

LOURENÇO, André Luís Cabral de ; Macedo, Luziene Dantas de ; SILVA,Marconi Gomes da ; BEZERRA, Márcia Maria de Oliveira ; PEREIRA, W. E. N. . O processo de acumulação na economia política clássica: uma interpretação não-convencional a partir da leitura dos ricos detalhes comumente inexplorados. In: Encontro Nacional de Economia Política, 14., 2009, São Paulo. Anais... São Paulo, 2009.

Um middleware como interface padrão para acesso a dispositivos biomédicos

A grande diversidade na arquitetura de dispositivos de hardware, aliada aos seus diferentes protocolos de comunicação, tem dificultado a implementação de sistemas que necessitam realizar o acesso a esses dispositivos. Diante dessas diferenças, surge a necessidade de prover o acesso a esses dispositivos de forma transparente. Neste sentido, o presente trabalho propõe um middleware mult entrada e saída para acesso a dispositivos, como forma de abstrair o mecanismo de escrita e leitura de dados em dispositivos de hardware, contribuindo desta forma, para o aumento na produtividade dos sistemas, uma vez que os desenvolvedores estão focados apenas nos seus requisitos funcionais

Avaliação do padrão de resposta de imunoglobulinas em diferentes linhagens de camundongos frente à infecção por T.cruzi

Dissertação (Mestrado)

Chemical characterization and evaluation of biological activity of Cynara cardunculus extractable compounds

The Mediterranean species Cynara cardunculus L. is recognized in the traditional medicine, for their hepatoprotective and choleretic effects. Biomass of C. cardunculus L. var. altilis (DC), or cultivated cardoon, may be explored not only for the production of energy and pulp fibers, but also for the extraction of bioactive compounds. The chemical characterization of extractable components, namely terpenic and phenolic compounds, may valorize the cultivated cardoon plantation, due to their antioxidant, antitumoral and antimicrobial activities. In this study, the chemical composition of lipophilic and phenolic fractions of C. cardunculus L. var. altilis (DC), cultivated in the south of Portugal (Baixo Alentejo region) was characterized in detail, intending the integral valorization of its biomass. The biological activity of cultivated cardoon extracts was evaluated in terms of antioxidant, human tumor cell antiproliferative and antibacterial effects. Gas chromatography-mass spectrometry (GC-MS) was used for the chemical analysis of lipophilic compounds. Sixty-five lipophilic compounds were identified, from which 1 sesquiterpene lactone and 4 pentacyclic triterpenes were described, for the first time, as cultivated cardoon components, such as: deacylcynaropicrin, acetates of β- and α-amyrin, lupenyl acetate and ψ-taraxasteryl acetate. Sesquiterpene lactones were the major family of lipophilic components of leaves (≈94.5 g/kg), mostly represented by cynaropicrin (≈87.4 g/kg). Pentacyclic triterpenes were also detected, in considerably high contents, in the remaining parts of cultivated cardoon, especially in the florets (≈27.5 g/kg). Taraxasteryl acetate was the main pentacyclic triterpene (≈8.9 g/kg in florets). High pressure liquid chromatography-mass spectrometry (HPLC-MS) was utilized for the chemical analysis of phenolic compounds. Among the identified 28 phenolic compounds, eriodictyol hexoside was reported for the first time as C. cardunculus L. component, and 6 as cultivated cardoon components, namely 1,4-di-O-caffeoylquinic acid, naringenin 7-O-glucoside, naringenin rutinoside, naringenin, luteolin acetylhexoside and apigenin acetylhexoside. The highest content of the identified phenolic compounds was observed in the florets (≈12.6 g/kg). Stalks outer part contained the highest hydroxycinnamic acids abundance (≈10.3 g/kg), and florets presented the highest flavonoids content (≈10.3 g/kg). The antioxidant activity of phenolic fraction was examined through 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Stalks outer part, and receptacles and bracts extracts demonstrated the highest antioxidant effect on DPPH (IC50 of 34.35 μg/mL and 35.25 μg/mL, respectively). (cont.) abstract (cont.) The DPPH scavenging effect was linearly correlated with the total contents of hydroxycinnamic acids (r = -0.990). The in vitro antiproliferative activity of cultivated cardoon lipophilic and phenolic extracts was evaluated on a human tumor cells line of triple-negative breast cancer (MDA-MB-231), one of the most refractory human cancers to conventional therapeutics. After 48 h of exposition, leaves lipophilic extract showed higher inhibitory effect (IC50 = 10.39 μg/mL) than florets lipophilic extract (IC50 = 315.22 μg/mL), upon MDA-MB-231 cellular viability. Pure compound of cynaropicrin, representative of the main compound identified in leaves lipophilic extract, also prevented the cell proliferation of MDA-MB-231 (IC50 = 17.86 μM). MDA-MB-231 cells were much more resistant to the 48 h- treatment with phenolic extracts of stalks outer part (IC50 = 3341.20 μg/mL) and florets (IC50 > 4500 μg/mL), and also with the pure compound of 1,5-di-O-caffeoylquinic acid (IC50 = 1741.69 μM). MDA-MB-231 cells were exposed, for 48 h, to the respective IC50 concentrations of leaves lipophilic extract and pure compound of cynaropicrin, in order to understand their ability in modelling cellular responses, and consequently important potentially signaling pathways for the cellular viability decrease. Leaves lipophilic extract increased the caspase-3 enzymatic activity, contrarily to pure compound of cynaropicrin. Additionally, leaves lipophilic extract and pure compound of cynaropicrin caused G2 cell cycle arrest, possibly by upregulating the p21Waf1/Cip1 and the accumulation of phospho-Tyr15-CDK1 and cyclin B1. The inhibitory effects of leaves lipophilic extract and cynaropicrin pure compound, against the MDA-MB-231 cell proliferation, may also be related to the downregulation of phospho-Ser473-Akt. The antibacterial activity of cultivated cardoon lipophilic and phenolic extracts was assessed, for the first time, on two multidrug-resistant bacteria, such as the Gram-negative Pseudomonas aeruginosa PAO1 and the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA), two of the main bacteria responsible for health care-associated infections. Accordingly, the minimum inhibitory concentrations (MIC) were determined. Lipophilic and phenolic extracts of florets did not have antibacterial activity on P. aeruginosa PAO1 and MRSA (MIC > 2048 μg/mL). Leaves lipophilic extract did not prevent the P. aeruginosa PAO1 growth, but pure compound of cynaropicrin was slightly active (MIC = 2048 μg/mL). Leaves lipophilic extract and pure compound of cynaropicrin blocked MRSA growth (MIC of 1024 and 256 μg/mL, respectively). The scientific knowledge revealed in this thesis, either by the chemical viewpoint, or by the biological viewpoint, contributes for the valorization of C. cardunculus L. var. altilis (DC) biomass. Cultivated cardoon has potential to be exploited as source of bioactive compounds, in conciliation with other valorization pathways, and Portuguese traditional cheeses manufacturing.

UBS RN-7: proposta arquitetônica para um padrão flexível de unidade básica de saúde para a zona bioclimática 7 do RN, com ênfase na sustentabilidade ambiental

Standardization and sustainability: these two apparently antagonistic words find the challenge of uniting in a flexible architectonic proposal. This was the idea that motivated the proposal of this assignment, whose appearing is bound up with the necessity of thinking about standardized spaces that attend on functional criterias and environmental sustainability, in reply to an existing real demand. The assignment consists of an architectonic proposal for a flexible standard of a Basic Unit of Health for the bioclimatic zone 7 of RN (UBS RN-7), with emphasis in the environmental sustainability. The project contemplates innumerable involved variables, such as: obedience to the current law of the Health Ministry for the UBSs; formal/aesthetic aspects; criterias of expansiveness of the UBS I for the UBS II; relative aspects to the constructive rationality and, mainly, sustainability aspects. With the intention to unite the variables and, also, glimpsing a proposal that could reach a good functional performance, aesthetic, of environment comfort and energetic efficiency, it was also necessary to consider concepts about the flexibility of the envelopment. The elaboration of the architecture first draft was based on bibliographical research, conceptual studies and references, elaboration of the architectonic program and the draft development for the UBS port I and the UBS port II. To the end, an implantation data sheet for the project is proposed for the UBS standard project, where strategies of thermal isolation, shadowing and thermal inertia are adopted and combined to three possible types of lot, resulting in 24 possibilities of implantation

Influência da adição de resíduo de caulim nas propriedades tecnológicas de uma massa padrão de porcelanato produzido em escala industrial

VARELA, M. L. et al. Influência da adição de resíduo de caulim nas propriedades tecnológicas de uma massa padrão de porcelanato produzido em escala industrial. Cerâmica, v.55, n.334 p.209-215. 2009.ISSN 0366-6913.Disponível em: . Acesso em: 06 out. 2010.

O processo de acumulação na economia política clássica: uma interpretação não convencional a partir da leitura dos ricos detalhes comumente inexplorados

LOURENÇO, André Luís Cabral de ; Macedo, Luziene Dantas de ; SILVA,Marconi Gomes da ; BEZERRA, Márcia Maria de Oliveira ; PEREIRA, W. E. N. . O processo de acumulação na economia política clássica: uma interpretação não-convencional a partir da leitura dos ricos detalhes comumente inexplorados. In: Encontro Nacional de Economia Política, 14., 2009, São Paulo. Anais... São Paulo, 2009.