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Motor Vehicle Crash Fatalities for Week Ending, May 14, 2010

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Motor Vehicle Crash Fatalities for Week Ending, May 21, 2010

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Motor Vehicle Crash Fatalities for Week Ending, May 28, 2010

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Motor Vehicle Crash Fatalities for Week Ending, June 4, 2010

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Motor Vehicle Crash Fatalities for Week Ending, June 11, 2010

Motor Vehicle Crash Fatalities

FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.

FLICE-inhibitory protein, FLIP (Casper/I-FLICE/FLAME-1/CASH/CLARP/MRIT), which contains two death effector domains and an inactive caspase domain, binds to FADD and caspase-8, and thereby inhibits death receptor-mediated apoptosis. Here, we characterize the inhibitory effect of FLIP on a variety of apoptotic pathways. Human Jurkat T cells undergoing Fas ligand-mediated apoptosis in response to CD3 activation were completely resistant when transfected with FLIP. In contrast, the presence of FLIP did not affect apoptosis induced by granzyme B in combination with adenovirus or perforin. Moreover, the Fas ligand, but not the perforin/granzyme B-dependent lytic pathway of CTL, was inhibited by FLIP. Apoptosis mediated by chemotherapeutic drugs (i.e., doxorubicin, etoposide, and vincristine) and gamma irradiation was not affected by FLIP or the absence of Fas, indicating that these treatments can induce cell death in a Fas-independent and FLIP-insensitive manner.

Motor Vehicle Crash Fatalities for Week Ending, June 18, 2010

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Motor Vehicle Crash Fatalities for Week Ending, June 25, 2010

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Motor Vehicle Crash Fatalities for Week Ending, July 9, 2010

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Motor Vehicle Crash Fatalities for Week Ending, July 16, 2010

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Motor Vehicle Crash Fatalities for Week Ending, July 23, 2010

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Motor Vehicle Crash Fatalities for Week Ending, July 30, 2010

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Motor Vehicle Crash Fatalities for Week Ending, August 6, 2010

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