A calendar of wills proved in the Consistory Court of the Bishop of Gloucester, 1541 [to 1800]

Wills during 1653-60 were proved in London, hence must be sought in the Principal Registry, Somerset House. cf. v. 1, p. viii.

Annual report of the Board of Public Works to the General Assembly of Virginia, with the accompanying documents.

Title varies.

Ancient geography, as connected with chronology, and preparatory to the study of ancient history; accompanied with an atlas. Compiled chiefly from D'Anville, Adam, Lavoisne, Malte Brun, and other standard works. To which are added problems on the globes, and rules for the construction of maps. To accompany the modern geography by William C. Woodbridge.

Bound with Woodbridge, W.C. A system of universal geography. Hartford 1835.

Lives of the most eminent English poets: with critical observations on their works. To which are added the "Preface to Shakespeare," and the review of "The origin of evil."

Mode of access: Internet.

Love & friendship and other early works : now first printed from the original ms. /

Love and friendship -- Lesley Castle -- The history of England -- Collection of letters -- Scraps.

Whole works, to which is prefixed, A life of the author,

Mode of access: Internet.

The optimisation of legacy water treatment works to produce a more consistent final water quality

DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ARRANGEMENT

Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease

Poor maternal nutrition during pregnancy can alter postnatal phenotype and increase susceptibility to adult cardiovascular and metabolic diseases. However, underlying mechanisms are largely unknown. Here, we show that maternal low protein diet (LPD), fed exclusively during mouse preimplantation development, leads to offspring with increased weight from birth, sustained hypertension, and abnormal anxiety-related behavior, especially in females. These adverse outcomes were interrelated with increased perinatal weight being predictive of later adult overweight and hypertension. Embryo transfer experiments revealed that the increase in perinatal weight was induced within blastocysts responding to preimplantation LPD, independent of subsequent maternal environment during later pregnancy. We further identified the embryo-derived visceral yolk sac endoderm (VYSE) as one mediator of this response. VYSE contributes to fetal growth through endocytosis of maternal proteins, mainly via the multiligand megalin (LRP2) receptor and supply of liberated amino acids. Thus, LPD maintained throughout gestation stimulated VYSE nutrient transport capacity and megalin expression in late pregnancy, with enhanced megalin expression evident even when LPD was limited to the preimplantation period. Our results demonstrate that in a nutrient-restricted environment, the preimplantation embryo activates physiological mechanisms of developmental plasticity to stablize conceptus growth and enhance postnatal fitness. However, activation of such responses may also lead to adult excess growth and cardiovascular and behavioral diseases. © 2008 by the Society for the Study of Reproduction, Inc.