Decreto auctorizando a Meza do Desembargo do Paço para confirmar todas as Sesmarias, e para as conceder na Corte, e os Governadores nas suas Capitanias

Título retirado da: Bibliografia da Impressão Régia do Rio de Janeiro.

Memorias historicas do Rio de Janeiro e das provincias annexas à jurisdicção do Vice-Rei do Estado do Brasil, dedicadas a El-Rei Nosso Senhor D. João VI

Silva, Innocencio Francisco da. Diccionario bibliographico portuguez. Lisboa : Na Imprensa Nacional, 1858-1923.v. 5, p. 139.

Legislación y Deontología - Aprendizaje Basado en Problemas

Duración (en horas): Más de 50 horas. Destinatario: Estudiante

Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier

[EN] The aims of this work were (i) to evaluate the potential of nanostructured lipid carriers (NLCs) as a tool to 24 enhance the oral bioavailability of poorly soluble compounds using saquinavir (SQV), a BCS class IV drug 25 and P-gp substrate as a model drug, and (ii) to study NLC transport mechanisms across the intestinal barrier. 26 Three different NLC formulations were evaluated. SQV transport across Caco-2 monolayers was enhanced up 27 to 3.5-fold by NLCs compared to SQV suspension. M cells did not enhance the transport of NLCs loaded with 28 SQV. The size and amount of surfactant in the NLCs influenced SQV's permeability, the transcytosis pathway 29 and the efflux of SQV by P-gp. An NLC of size 247 nm and 1.5% (w/v) surfactant content circumvented P-gp 30 efflux and used both caveolae- and clathrin-mediated transcytosis, in contrast to the other NLC formulations, 31 which used only caveolae-mediated transcytosis. By modifying critical physicochemical parameters of the 32 NLC formulation, we were thus able to overcome the P-gp drug efflux and alter the transcytosis mechanism 33 of the nanoparticles. These findings support the use of NLCs approaches for oral delivery of poorly 34 water-soluble P-gp substrates.

Elektromagnetismoaren oinarri fisikoak

Helburuak: Materialaren helburua elkarrekintza elektromagnetikoaren oinarriak ahalik eta erarik argiena azaltzea da, Fisikaren oinarrizko printzipioekin duten lotura azpimarratuz. Hori dela eta, gaian sakonkiago murgildu behar dutenentzat harrera izan daiteke. Irakurleak elektromagnetismoaren oinarrizko kontzeptuak eta printzipioak ulertzea ez ezik, kasu sinpleetan erabiltzen jakitea da xedea: eguneroko fenomeno elektrikoen zergatia, zirkuituen funtzionamendua, energia elektrikoaren sorkuntza, ... Norentzat izan daiteke baliagarria: Teknologian edota zientzian interesa duten guztientzat, ingeniaritzaren eta zientziaren lehenengo mailako ikasleak, bereziki.

Cannabis use and involuntary admission may mediate long-term adherence in first-episode psychosis patients: a prospective longitudinal study

Background: This study aimed to examine factors associated with treatment adherence in first-episode psychosis (FEP) patients followed up over 8 years, especially involuntary first admission and stopping cannabis use. Methods: This prospective, longitudinal study of FEP patients collected data on symptoms, adherence, functioning,and substance use. Adherence to treatment was the main outcome variable and was categorized as ‘good’ or ‘bad’. Cannabis use during follow-up was stratified as continued use, stopped use, and never used. Bivariate and logistic regression models identified factors significantly associated with adherence and changes in adherence over the 8-year follow-up period. Results: Of the 98 FEP patients analyzed at baseline, 57.1% had involuntary first admission, 74.4% bad adherence,and 52% cannabis use. Good adherence at baseline was associated with Global Assessment of Functioning score (p = 0.019), Hamilton Depression Rating Scale score (p = 0.017) and voluntary admission (p < 0.001). Adherence patterns over 8 years included: 43.4% patients always bad, 26.1% always good, 25% improved from bad to good. Among the improved adherence group, 95.7% had involuntary first admission and 38.9% stopped cannabis use. In the subgroup of patients with bad adherence at baseline, involuntary first admission and quitting cannabis use during follow up were associated with improved adherence. Conclusions: The long-term association between treatment adherence and type of first admission and cannabis use in FEP patients suggest targets for intervention to improve clinical outcomes.

Contributions to unsupervised and supervised learning with applications in digital image processing

311 p. : il.

Diário da Constituinte [gravação de vídeo] : [programa n. 688]

Os constituintes aprovam os direitos sociais: licença-maternidade, paternidade, jornada semanal de 44 horas, jornada de 6 horas para turnos ininterruptos, etc. O balanço das conquistas foi bastante positivo. Um dos pontos pendentes é o direito de greve e o capítulo dos direitos políticos, com a polêmica do voto aos 16 anos.

Diário da Constituinte [gravação de vídeo] : [programa n. 644]

Os constituintes apresentaram muitas emendas para retirar a licença para a gestante de 120 dias, e o turno de seis horas de jornada de trabalho. O líder do governo Carlos Sant'ana deseja retirar a matéria da jornada de seis horas, pois acredita que prejudicará a Petrobrás.

Biocompatible Bacterial Cellulose-Poly(2-hydroxyethyl methacrylate) Nanocomposite Films

A series of bacterial cellulose-poly(2-hydroxyethyl methacrylate) nanocomposite films was prepared by in situ radical polymerization of 2-hydroxyethyl methacrylate (HEMA), using variable amounts of poly(ethylene glycol) diacrylate (PEGDA) as crosslinker. Thin films were obtained, and their physical, chemical, thermal, and mechanical properties were evaluated. The films showed improved translucency compared to BC and enhanced thermal stability and mechanical performance when compared to poly(2-hydroxyethyl methacrylate) (PHEMA). Finally, BC/PHEMA nanocomposites proved to be nontoxic to human adipose-derived mesenchymal stem cells (ADSCs) and thus are pointed as potential dry dressings for biomedical applications.

Análisis de la utilidad de la olfatogustometría mediante BAST-24 en la población diabética y su relación con la función renal

157 p. : il., graf.

Determinants of self-reported smoking and misclassification during pregnancy, and analysis of optimal cut-off points for urinary cotinine: a cross-sectional study

10 p.

Advances in Click Chemistry for Single-Chain Nanoparticle Construction

Single-chain polymeric nanoparticles are artificial folded soft nano-objects of ultra-small size which have recently gained prominence in nanoscience and nanotechnology due to their exceptional and sometimes unique properties. This review focuses on the current state of the investigations of click chemistry techniques for highly-efficient single-chain nanoparticle construction. Additionally, recent progress achieved for the use of well-defined single-chain nanoparticles in some promising fields, such as nanomedicine and catalysis, is highlighted.

Diário da Constituinte [gravação de vídeo] : [programa n. 369]

O projeto de Constituição já aprovado nas etapas anteriores da Constituinte prevê eleições presidenciais no próximo ano. A decisão foi tomada numa sessão histórica da Comissão de Sistematização. O autor da emenda dos 4 anos acredita que a vitória se repetirá no Plenário. Contra os 4 anos existem 2 obstáculos: Um é o próprio Presidente Sarney, após ter definido seu mandato em 4 anos, mudou para 5 anos. O outro obstáculo é o tempo. O Plenário da Constituinte ainda não começou. Os mais otimistas acham que as votações começam em final de janeiro. Com isto, não há previsão de quando ficará pronta a nova Carta. Dois fatores importantes poderão ser levados em conta pela Constituinte: a crise econômica e a vontade de mudar. A vontade popular parece pedir 4 anos e eleições diretas em 1988.

Diário da Constituinte [gravação de vídeo] : [programa n. 370]

Na etapa das Comissões os trabalhadores conseguiram aprovar a redução da jornada de 48 horas semanais para 40 horas. Outro projeto prevê jornada de 8 horas diárias. Estabeleceu-se um novo meio termo: a jornada de 44 horas semanais. O povo opina sobre a licença maternidade de 120 dias. O aumento da licença gestante de 90 para 120 dias foi uma das lutas das mulheres na Constituinte. Na votação final da Comissão de Sistematização, a licença de 120 dias voltou a ser aprovada. A questão será definida em Plenário e os constituintes que defendem a licença acham que ela é um direito fundamental.