991 resultados para Jacobi, Georg Arnold, 1766-1845


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Welsch (Projektbearbeiter): Rühmende Schilderung der militärischen Leistungen von Mitgliedern des Wiener Freiwilligen-Korps, die sich im Kampf Österreichs gegen die Truppen Piemont-Sardiniens in der Lombardei besonders hervorgetan haben

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Im Dreissigjährigen Krieg wurde die Schweiz zum Auge des Hurrikans. Aus einer grenzüberschreitenden Perspektive betrachten die Autoren des Bandes die damalige politische und kulturelle Dynamik. Diplomatie und Militärunternehmertum im Dienst europäischer Mächte eröffneten den eidgenössischen Machteliten während des langen Krieges attraktive Betätigungsfelder. Die Kunst- und Architekturgeschichte sowie die Bibliotheksgeschichte bestätigen die transnationale Verflechtung der Eidgenossenschaft. Frühbarocke Architektur und zeitgenössische Porträtmalerei waren für die Selbstdarstellung und Kunstpatronage der eidgenössischen Eliten zentral. Die eidgenössischen Eliten waren Teil der Gelehrten-Netzwerke Europas, die die reformierte Eidgenossenschaft prominent im Zentrum des internationalen Protestantismus situieren wollten. Herausgegeben von André Holenstein, Professor für ältere Schweizer Geschichte an der Universität Bern, und Georg von Erlach, Präsident der Stiftung Schloss Spiez. Mit Beiträgen von Andrea Arnold, Barbara Egli, Claudia Engler, Norbert Furrer, Randolph C. Head, André Holenstein, Peter Niederhäuser, Philippe Rogger, Barbara Schmid, Jürg Schweizer, Andreas Würgler.

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Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.

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Manfred Laubert

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BACKGROUND Reported frequency of post-stroke dysphagia in the literature is highly variable. In view of progress in stroke management, we aimed to assess the current burden of dysphagia in acute ischemic stroke. METHODS We studied 570 consecutive patients treated in a tertiary stroke center. Dysphagia was evaluated by using the Gugging Swallowing Screen (GUSS). We investigated the relationship of dysphagia with pneumonia, length of hospital stay and discharge destination and compared rates of favourable clinical outcome and mortality at 3 months between dysphagic patients and those without dysphagia. RESULTS Dysphagia was diagnosed in 118 of 570 (20.7%) patients and persisted in 60 (50.9%) at hospital discharge. Thirty-six (30.5%) patients needed nasogastric tube because of severe dysphagia. Stroke severity rather than infarct location was associated with dysphagia. Dysphagic patients suffered more frequently from pneumonia (23.1% vs. 1.1%, p<0.001), stayed longer at monitored stroke unit beds (4.4±2.8 vs. 2.7±2.4 days; p<0.001) and were less often discharged to home (19.5% vs. 63.7%, p = 0.001) as compared to those without dysphagia. At 3 months, dysphagic patients less often had a favourable outcome (35.7% vs. 69.7%; p<0.001), less often lived at home (38.8% vs. 76.5%; p<0.001), and more often had died (13.6% vs. 1.6%; p<0.001). Multivariate analyses identified dysphagia to be an independent predictor of discharge destination and institutionalization at 3 months, while severe dysphagia requiring tube placement was strongly associated with mortality. CONCLUSION Dysphagia still affects a substantial portion of stroke patients and may have a large impact on clinical outcome, mortality and institutionalization.

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A. L.

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A. L.

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Scan von Monochrom-Mikroform

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Scan von Monochrom-Mikroform

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Scan von Monochrom-Mikroform