Pleiotropic Analysis of Lung Cancer and Blood Triglycerides

Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lung cancer case patients and 16 838 control subjects) and cardiovascular disease risk factors (blood lipids from 188 577 subjects, type 2 diabetes from 148 821 subjects, body mass index from 123 865 subjects, and smoking phenotypes from 74 053 subjects). We found that 6p22.1 (rs6904596, ZNF184) was associated with both lung cancer (P = 5.50x10(-6)) and blood triglycerides (P = 1.39x10(-5)). We replicated the association in 6097 lung cancer case patients and 204 657 control subjects (P = 2.40 × 10(-4)) and in 71 113 subjects with triglycerides data (P = .01). rs6904596 reached genome-wide significance in lung cancer meta-analysis (odds ratio = 1.15, 95% confidence interval = 1.10 to 1.21 ,: Pcombined = 5.20x10(-9)). The large sample size provided by the lipid GWAS data and the shared genetic risk factors between the two traits contributed to the uncovering of a hitherto unidentified genetic locus for lung cancer.

Towards optical polarization control of laser-driven proton acceleration in foils undergoing relativistic transparency

Control of the collective response of plasma particles to intense laser light is intrinsic to relativistic optics, the development of compact laser-driven particle and radiation sources, as well as investigations of some laboratory astrophysics phenomena. We recently demonstrated that a relativistic plasma aperture produced in an ultra-thin foil at the focus of intense laser radiation can induce diffraction, enabling polarization-based control of the collective motion of plasma electrons. Here we show that under these conditions the electron dynamics are mapped into the beam of protons accelerated via strong charge-separation-induced electrostatic fields. It is demonstrated experimentally and numerically via 3D particle-in-cell simulations that the degree of ellipticity of the laser polarization strongly influences the spatial-intensity distribution of the beam of multi-MeV protons. The influence on both sheath-accelerated and radiation pressure-accelerated protons is investigated. This approach opens up a potential new route to control laser-driven ion sources.

Yellow Perch Population Assessment in Southwestern Lake Michigan, Including the Identification of Factors that Determine Yellow Perch Year-Class Strength April 1, 2003 - March 31, 2004

Annual Report to Division of Fisheries, Illinois Department of Natural Resources. F-123-R-10

Yellow Perch population assessment in Southwestern Lake Michigan, including evaluation of sampling techniques and identification of the factors that determine Yellow Perch year-class strength April 1, 2004 - March 31, 2005

ID: 8528; Annual Report to Division of Fisheries, Illinois Department of Natural Resources; F-123-R-11

Yellow Perch Population Assessment in Southwestern Lake Michigan, Including Evaluation of Sampling Techniques and Identification of factors that Determine Yellow Perch Year-Class Strength April 1, 2005 - March 31, 2006

Annual Report, Federal Aid Project F-123-R-12, April 1, 2005 - March 31, 2006

Expression and Role of CD166 in the Chronic Kidney Disease

Background: CD166, an adhesion molecule of the immunoglobulin superfamily, is one of the crucial effectors that traffic lymphocytes into tissues. Till now, the expression and role of CD166 in the chronic kidney disease remains unknown. Objectives: In the present study, we are to examine the expression of CD166 in the chronic kidney disease, and to explore its function with CD4+ T cells. Materials and Methods: CD166 expression was tested by Flow Cytometry (FACS) in the primary macrophages stimulated with LPS. In vivo, the expression of CD166 and CD4 were examined in the kidney tissues of adriamycin-induced nephropathy (AN) mice by immnohistochemistry. Macrophages and lymphocytes were co-cultured, the interaction between CD166 and CD4 was tested by immunofluorescent staining. Furthermore, the effects of CD166 on the activation and proliferation of T cells were explored. Results: In this study, CD166 expression was found to be upregulated on activated macrophages and glomerular endothelia in the adriamycin-induced nephropathy (AN) mice and CD4+ T cells were increased with CD166 expression in the AN mice. The interaction between macrophages and CD4+ T cells indicated that CD166 played a key role in the recruitment of lymphocytes in the chronic kidney disease, and neither proliferation nor activation of T cells was affected by CD166. Conclusions: CD166 expressed on macrophages and endothelia in AN kidney, and the function was related to the recruitment of CD4+ T cells into inflamed kidney, indicating that CD166 may be a potential target for reducing the inflammatory infiltrates in the chronic kidney disease.

El papel del tráfico ilícito de armas pequeñas y ligeras como amenaza a la seguridad en Guatemala entre 2000 y 2005

El propósito del trabajo es exponer de qué manera el tráfico ilícito de armas pequeñas y ligeras constituye una amenaza a la seguridad en Guatemala durante el 2000 y 2005. La aproximación conceptual se centrará en las ideas de la Seguridad de Charles-Philippe David, puesto que servirá como herramienta para el análisis de la coyuntura guatemalteca. Así, se pretende dar cuenta del fortalecimiento de actores ilegales de crimen internacional organizado, narcotráfico, maras y pandillas, lo que da lugar al incremento de la violencia armada afectando diferentes esferas como la política, societal y económica.

The birds of Sibuyan Island, Romblon Province, Philippines : with particular reference to elevational distribution and biogeographic affinities / Steven M. Goodman, David E. Willard, Pedro C. Gonzales.

n.s. no.82(1995)

Paraphrase des C.L. Pseaumes de David tant literale que mystique avec annotations necessaires... Edition seconde... Par Antoine de Laval...

[Bible. A.T.. Psaumes (latin-français). 1614. Laval]

Typenprobe aus Nebim Rischonion C. Jonat. Targum [Illustration] : David Kimchi et Levi Gersonidis Comm.

Scan von Monochrom-Mikroform

Ms. Ff. Mus. 1135 - Am 1. Advent : Hosianna dem Sohne David! ; gelobet sey p. ; C. C. A. T. B., 2 oboe et flauti, 2 violini, 1 viola, violoncello et organo

von Telemann. [Textdichter: Gottfried Simonis]